Article
Refine
Year of publication
Document Type
- Article (1853) (remove)
Language
- English (1853) (remove)
Is part of the Bibliography
- no (1853)
Keywords
- - (1113)
- proteomics (26)
- plasma medicine (25)
- reactive oxygen species (24)
- COVID-19 (22)
- climate change (21)
- Germany (19)
- periodontitis (18)
- stroke (18)
- biocatalysis (16)
- depression (16)
- ROS (15)
- cold physical plasma (14)
- inflammation (14)
- biomarker (13)
- dementia (11)
- epidemiology (11)
- metabolomics (11)
- microbiome (11)
- sepsis (11)
- SARS-CoV-2 (10)
- biofilm (10)
- kINPen (10)
- machine learning (10)
- <i>Staphylococcus aureus</i> (9)
- Alzheimer’s disease (9)
- antibiotic resistance (9)
- mass spectrometry (9)
- oncology (9)
- platelets (9)
- quality of life (9)
- MRI (8)
- antimicrobial resistance (8)
- cancer (8)
- gene expression (8)
- multiple sclerosis (8)
- neuroblastoma (8)
- phenotypic plasticity (8)
- reactive oxygen and nitrogen species (8)
- rehabilitation (8)
- Depression (7)
- aging (7)
- children (7)
- infection (7)
- mortality (7)
- resistance (7)
- vaccine (7)
- validation (7)
- Epidemiology (6)
- Sepsis (6)
- apoptosis (6)
- autoinflammation (6)
- cerebrospinal fluid (6)
- cognition (6)
- cold atmospheric pressure plasma (6)
- colonization (6)
- cytotoxicity (6)
- immunotherapy (6)
- inhibition (6)
- innate immunity (6)
- metaproteomics (6)
- miRNA (6)
- microbiota (6)
- periacetabular osteotomy (6)
- pregnancy (6)
- proteasome (6)
- protein engineering (6)
- public health (6)
- synthesis (6)
- telemedicine (6)
- transcriptomics (6)
- Biocatalysis (5)
- Children (5)
- ESBL (5)
- Inflammation (5)
- Obesity (5)
- Pancreatic cancer (5)
- SLC22A1 (5)
- Telemedicine (5)
- acute pancreatitis (5)
- antibiotics (5)
- antibody (5)
- asthma (5)
- atomic force microscopy (5)
- behavior change (5)
- bile acids (5)
- biomarkers (5)
- clinical (5)
- cytokines (5)
- dinutuximab beta (5)
- drug resistance (5)
- epilepsy (5)
- fatty acids (5)
- gender (5)
- immune response (5)
- local adaptation (5)
- magnetic resonance imaging (5)
- mental health (5)
- metabolism (5)
- mitochondria (5)
- monocytes (5)
- motor rehabilitation (5)
- network analysis (5)
- obesity (5)
- oxidative stress (5)
- paludiculture (5)
- pancreatic ductal adenocarcinoma (5)
- pancreatitis (5)
- prognosis (5)
- rewetting (5)
- seizure (5)
- social cognition (5)
- surface charge (5)
- survival (5)
- transcriptome (5)
- virulence (5)
- <i>Streptococcus pneumoniae</i> (4)
- Assessment (4)
- BCL11B (4)
- Baltic Sea (4)
- CAP (4)
- CRISPR/Cas9 (4)
- Chemotherapy (4)
- Chronic kidney disease (4)
- Delphi study (4)
- ECG (4)
- G-quadruplexes (4)
- GWAS (4)
- Immunoglobulin G (4)
- K (4)
- MCID (4)
- MRSA (4)
- OCT1 (4)
- One Health (4)
- P188 (4)
- Quality of life (4)
- RNA (4)
- RNS (4)
- Staphylococcus aureus (4)
- Systematic review (4)
- adolescents (4)
- allergy (4)
- alpha-toxin (4)
- antibacterial activity (4)
- antimicrobial (4)
- antimicrobial peptides (4)
- autophagy (4)
- bacteria (4)
- barrier discharge (4)
- bentonite (4)
- biogeography (4)
- brain (4)
- cerebral cavernous malformation (4)
- chronic kidney disease (4)
- cohort study (4)
- cold atmospheric plasma (4)
- copolymer (4)
- cystic fibrosis (4)
- deep learning (4)
- dendrochronology (4)
- diagnosis (4)
- diagnostics (4)
- differentiation (4)
- diffusion tensor imaging (4)
- electrochemistry (4)
- emotion (4)
- exercise (4)
- fatigue (4)
- free light chain kappa (4)
- group A streptococcus (4)
- health-related quality of life (4)
- heart failure (4)
- hepatocellular carcinoma (4)
- human (4)
- infection prevention (4)
- inflammasome (4)
- interaction (4)
- liver (4)
- magnetron sputtering (4)
- melioidosis (4)
- memory (4)
- moral disengagement (4)
- neutrophils (4)
- organic cation transporter 1 (4)
- outcome (4)
- outcome measures (4)
- oxylipins (4)
- pain (4)
- pandemic (4)
- pig (4)
- platelet factor 4 (4)
- prediction (4)
- prostate cancer (4)
- proteome (4)
- questionnaire (4)
- redox signaling (4)
- sphingosine-1-phosphate (4)
- substituent (4)
- thermodynamics (4)
- tooth loss (4)
- training (4)
- ubiquitin (4)
- women (4)
- 52.70.Ds (3)
- <i>Bacillus subtilis</i> (3)
- <i>S. aureus</i> (3)
- <i>Streptococcus pyogenes</i> (3)
- Alexithymia (3)
- Allogeneic stem cell transplantation (3)
- Alzheimer's disease (3)
- Araneae (3)
- B cells (3)
- Biofilm (3)
- COVID-19 pandemic (3)
- CRPS (3)
- Caries (3)
- Caries epidemiology (3)
- Caries experience (3)
- Central Asia (3)
- Cerebral cavernous malformations (3)
- Childhood trauma (3)
- Chiroptera (3)
- DNA barcoding (3)
- EEG (3)
- Enzym (3)
- Europe (3)
- FLT3-ITD (3)
- Gene expression (3)
- Haemorrhagic cystitis (3)
- IPMN (3)
- Intraductal papillary mucinous neoplasm (3)
- Lemnaceae (3)
- Mental health (3)
- Microvascular decompression (3)
- NGS (3)
- NMR spectroscopy (3)
- PASS (3)
- PRISMA (3)
- Polihexanide (3)
- Pregnancy (3)
- Prevalence (3)
- Prevention (3)
- Resilience (3)
- Risk factors (3)
- SCB (3)
- Satisfaction (3)
- Stereotypes (3)
- T cells (3)
- Thyroid (3)
- Vitamin D (3)
- adhesion (3)
- adolescence (3)
- adults (3)
- age (3)
- airway epithelial cells (3)
- anticancer drugs (3)
- antimicrobial resistance (AMR) (3)
- arm (3)
- artificial intelligence (3)
- assessment (3)
- asymmetric synthesis (3)
- atherosclerosis (3)
- attention (3)
- autoimmune (3)
- basal ganglia (3)
- bias (3)
- biodiversity (3)
- biotransformation (3)
- blood coagulation (3)
- blood–brain barrier (3)
- body mass index (3)
- boreal forest (3)
- bortezomib (3)
- brain tumor (3)
- breast cancer (3)
- caffeine (3)
- calorimetry (3)
- cancer therapy (3)
- cardiomyopathy (3)
- cardiopulmonary exercise testing (3)
- cardiorespiratory fitness (3)
- caries (3)
- case study (3)
- cattle trade (3)
- celecoxib (3)
- cell cycle (3)
- cell migration (3)
- chemokines (3)
- chemotherapy (3)
- chronic disease (3)
- chronic pancreatitis (3)
- coagulase-negative staphylococci (3)
- cognitive function (3)
- comorbidity (3)
- complication (3)
- computer vision (3)
- crystal structure (3)
- dendritic cells (3)
- dendrometer (3)
- diabetes (3)
- disturbance (3)
- drug release (3)
- duckweed (3)
- dusty plasma (3)
- eicosanoids (3)
- emotion recognition (3)
- emotion regulation (3)
- empathy (3)
- epidemic model (3)
- epigenetics (3)
- eutrophication (3)
- exacerbation (3)
- expression (3)
- fMRI (3)
- flupirtine (3)
- flux analysis (3)
- gap voltage (3)
- genetic adaptation (3)
- genotyping (3)
- glutathione (3)
- healthcare (3)
- host adaptation (3)
- hydrogen peroxide (3)
- immune system (3)
- immunity (3)
- immunoglobulin (3)
- immunohistochemistry (3)
- insula (3)
- ischemic stroke (3)
- laccase (3)
- lifestyle (3)
- lipid mediator (3)
- lipidomics (3)
- low temperature plasma (3)
- memory effect (3)
- mental illness (3)
- metabolome (3)
- metagenomics (3)
- migraine (3)
- modularity (3)
- morphology (3)
- motivation (3)
- mouse model (3)
- mouse models (3)
- n/a (3)
- natural products (3)
- neuroendocrine (3)
- observational study (3)
- osmotic stress adaptation (3)
- pancreas (3)
- pathogenesis (3)
- patient-reported outcome (3)
- peatland (3)
- peatland restoration (3)
- permutation entropy (3)
- physical activity (3)
- pneumococci (3)
- pneumonia (3)
- polyhydroxybutyrate (PHB) (3)
- preterm infant (3)
- prevalence (3)
- prevention (3)
- pro-environmental behavior (3)
- prognostic factors (3)
- proline (3)
- protein analytic (3)
- qualitative research (3)
- questionnaire development (3)
- regulation (3)
- reliability (3)
- retigabine (3)
- risk communication (3)
- saliva (3)
- salivary tracer technique (3)
- screening (3)
- sex (3)
- single nucleotide polymorphism (3)
- smectite (3)
- social (3)
- species differences (3)
- stochastic block model (3)
- stress (3)
- structure activity (3)
- subacute stroke (3)
- superantigens (3)
- survey (3)
- susceptibility testing (3)
- temperature (3)
- therapy (3)
- thrombosis (3)
- time series (3)
- tokamak (3)
- tolerance (3)
- transesterification (3)
- transporters (3)
- tree-ring width (3)
- tree-rings (3)
- treeline (3)
- ubiquitin-proteasome system (3)
- unfolded protein response (3)
- wound healing (3)
- 16S rRNA gene sequencing (2)
- 3D (2)
- 3D printing (2)
- <i>Burkholderia pseudomallei</i> (2)
- <i>E. coli</i> (2)
- A549 (2)
- AHI (2)
- ALK5 (2)
- AML (2)
- AMR (2)
- ATP synthesis (2)
- Acute pancreatitis (2)
- Aging (2)
- Agriculture (2)
- Alcohol dependence (2)
- Angiogenesis (2)
- Antiseptics (2)
- Arachnida (2)
- At-risk drinking (2)
- Austria (2)
- BK virus (2)
- Bacteroidetes (2)
- Barth syndrome (2)
- Barth syndrome (BTHS) (2)
- Biokatalyse (2)
- Biomarker (2)
- Biomolecules (2)
- Blood supply (2)
- Brain-derived neurotrophic factor (2)
- Breast cancer (2)
- C-reactive protein (2)
- CASP model (2)
- CD4 (2)
- CKD (2)
- CRISPR-Cas9 (2)
- CRISPR/Cas9 genome editing (2)
- CSF (2)
- Cardiovascular disease (2)
- Career (2)
- Caries index (2)
- Caries prevention (2)
- China (2)
- Chiral amines (2)
- Chorea (2)
- Climate change (2)
- Clinical guideline (2)
- Cluster analysis (2)
- Coagulation (2)
- Communication abilities (2)
- Comorbidity (2)
- Congenital hyperinsulinism (2)
- Consensus (2)
- Cortex (2)
- Covid-19 (2)
- Cystitis (2)
- CytoSorb (2)
- Cytokines (2)
- DNA (2)
- DNA repair (2)
- DTI (2)
- Dementia (2)
- Demographic change (2)
- Dental caries (2)
- Dental caries management (2)
- Dental caries terms (2)
- Developmental screening (2)
- Donor research (2)
- E. coli (2)
- ERV model (2)
- ESBL- (2)
- Electrochemically active bacteria (2)
- Enzyme discovery (2)
- European beech (2)
- Evolution (2)
- Ewing’s sarcoma (2)
- FAIR data principles (2)
- FGF21 (2)
- FOLFIRINOX (2)
- Feedback (2)
- Feminization (2)
- Fourier analysis (2)
- Fournier’s gangrene (2)
- Functional connectivity (2)
- GC-MS (2)
- Gender (2)
- German (2)
- Ghana (2)
- Glucocorticoid receptor (2)
- Guideline (2)
- HCMV (2)
- HIT (2)
- HL-60 (2)
- Health insurance (2)
- Health-related quality of life (2)
- Hemifacial spasm (2)
- Hirudin (2)
- Hsp27 (2)
- Hydrogen peroxide (2)
- Hyperbaric oxygenation (2)
- Hyperuricemia (2)
- ICUAW (2)
- IL-33 (2)
- IgE (2)
- Immunoglobulin M (2)
- Influenza A virus (2)
- Interreg (2)
- Iodine (2)
- JSNZ (2)
- KCNQ (2)
- L. (2)
- LC-MS/MS (2)
- LL-37 (2)
- Lake Balkhash (2)
- Landsat (2)
- Logarithmic capacity (2)
- Longitudinal (2)
- Magnetic resonance imaging, 7 T (2)
- Malabsorption (2)
- Maldigestion (2)
- Methylene blue (2)
- Morphologic changes (2)
- Mucositis (2)
- Multiple sclerosis (2)
- NAFLD (2)
- NOD1/2 (2)
- Nab-paclitaxel (2)
- Necrotizing fasciitis (2)
- Necrotomy (2)
- Neuroanatomy (2)
- Nipple discharge (2)
- North Rhine–Westphalia (2)
- Octenidine dihydrochloride (2)
- Older adults (2)
- Oxidative stress (2)
- PAR2 (2)
- PCV13 (2)
- PD-L1 (2)
- PDAC (2)
- PF4 (2)
- PTSD (2)
- Palliative chemotherapy (2)
- Pancreas (2)
- Pancreatic resection (2)
- Pantopoda (2)
- Pathogen inactivation (2)
- Pathological gambling (2)
- Patient management (2)
- Patient preferences (2)
- Patient-reported outcomes (2)
- Percidae (2)
- Pollution (2)
- Postoperative immune suppression (2)
- Posttraumatic stress disorder (2)
- Potentiometry (2)
- Prediction (2)
- Prefrontal cortex (2)
- Premanifest period (2)
- Primary care (2)
- Primary teeth (2)
- Prostate cancer (2)
- Protocol (2)
- Public health (2)
- Pulmonary arterial hypertension (2)
- Pyelonephritis (2)
- RCT (2)
- RNA sequencing (2)
- RNA-Seq (2)
- Randomized controlled trial (2)
- Risk factor (2)
- S1P (2)
- SEM–EDS (2)
- SNP (2)
- Saccharomyces cerevisiae (2)
- Self-efficacy (2)
- Self-stigma (2)
- Sepsis score (2)
- Significant Caries Index (2)
- Skin barrier (2)
- Small animal MRI (2)
- Snail (2)
- Socioeconomic status (2)
- Soft tissue infection (2)
- Spanish (2)
- Sphingosine-1-phosphate (2)
- Streptococcus pneumoniae (2)
- Substance use disorders (2)
- Surgery (2)
- Surgical discipline (2)
- Surgically induced immune dysfunction (2)
- Survival (2)
- T cell receptor signaling (2)
- TAP block (2)
- TGF-β (2)
- THA (2)
- THP-1 (2)
- Therapy (2)
- Thyroid-stimulating hormone (2)
- Ti6Al4V (2)
- Urinary tract infection (2)
- Urology (2)
- Validity (2)
- Virulence (2)
- Warburg effect (2)
- Work-life balance (2)
- X-ray analysis (2)
- YOLOv4 (2)
- abdominal sepsis (2)
- acupuncture (2)
- acyl transfer (2)
- acyltransferase (2)
- acyltransferases (2)
- adaptation (2)
- additive manufacturing (2)
- aerogel (2)
- agreement (2)
- alcohol (2)
- all-cause mortality (2)
- allicin (2)
- alternative splicing (2)
- amine transaminase (2)
- animal activity (2)
- animal monitoring (2)
- antares (2)
- anti-biofilm (2)
- antibacterial (2)
- antibiotic (2)
- anticancer drug (2)
- anticoagulants (2)
- anticonvulsants (2)
- antifungal (2)
- antimicrobial activity (2)
- antimicrobial photodynamic therapy (2)
- antiseptic stewardship (2)
- anxiety disorders (2)
- aptamer (2)
- aquatic plants (2)
- arousal (2)
- ascariasis (2)
- association study (2)
- atrial fibrillation (2)
- autocorrelation (2)
- autoimmunity (2)
- behaviour (2)
- biocide (2)
- biogas (2)
- bioinformatics (2)
- biological activities (2)
- biorelevant in vitro model (2)
- biotic interactions (2)
- bleeding (2)
- blood outgrowth endothelial cells (2)
- blood platelets (2)
- bolaform amphiphilic lipids (2)
- bolalipids (2)
- borderline personality disorder (2)
- boronate linkage (2)
- borrowing (2)
- brief intervention (2)
- broiler (2)
- bud dormancy (2)
- calcium retention capacity (2)
- calques (2)
- calves (2)
- carbohydrates (2)
- cardiac arrest (2)
- cardiac output (2)
- cardiolipin (2)
- cardiovascular disease (2)
- case report (2)
- castration-resistant prostate cancer (2)
- causal beliefs (2)
- causal inference (2)
- caveolae (2)
- cell mechanics (2)
- cell proliferation (2)
- cell signaling (2)
- cellular homeostasis (2)
- cellular proliferation (2)
- central blood pressure (2)
- cerebellum (2)
- cerebral cavernous malformations (2)
- chaperones (2)
- chemical ecology (2)
- chemical senses (2)
- child health (2)
- childhood maltreatment (2)
- chill (2)
- chondrocytes (2)
- chorioallantoic membrane model (2)
- chronic pain (2)
- chronic thromboembolic pulmonary hypertension (2)
- cisplatin (2)
- classification (2)
- climate extremes (2)
- climate warming (2)
- climate–growth relationships (2)
- clinical trials (2)
- co-infection (2)
- coagulation (2)
- cognitive behavioral analysis system of psychotherapy (2)
- cognitive behavioral therapy (2)
- cognitive control (2)
- cognitive training (2)
- colon cancer (2)
- colonic microbiota (2)
- colorectal cancer (2)
- combination therapy (2)
- comorbidities (2)
- confocal laser scanning microscopy (2)
- contact linguistics (2)
- cortisol (2)
- cross-reactivity (2)
- cross-resistance (2)
- cross-sectional (2)
- cross-tolerance (2)
- cyanobacteria (2)
- cytosolic renin (2)
- data stewardship (2)
- decision-making (2)
- decontamination (2)
- delirium (2)
- deployment (2)
- deubiquitination (2)
- development (2)
- diabetes mellitus (2)
- dialysis (2)
- diet (2)
- dietary behavior (2)
- diffusion weighted imaging (2)
- dipole magnetic field (2)
- disease risk (2)
- diseases (2)
- doxorubicin (2)
- drainage (2)
- drought (2)
- drug delivery system (2)
- drug transport (2)
- drug transporter (2)
- duckweeds (2)
- dusty plasmas (2)
- dynamic colon model (2)
- dyspnea (2)
- early experience (2)
- early-stage functionalisation (2)
- education (2)
- efavirenz (2)
- efficacy (2)
- electron–hole plasma (2)
- embodiment (2)
- emotions (2)
- endothelium (2)
- entropy (2)
- environment (2)
- enzyme catalysis (2)
- enzyme kits (2)
- erythrocytes (2)
- essential oil (2)
- ethics (2)
- everolimus (2)
- evidence (2)
- executive functions (2)
- experimental pancreatitis (2)
- exposure therapy (2)
- extracellular matrix (2)
- extracellular vesicles (2)
- face perception (2)
- family (2)
- fen (2)
- fenofibrate (2)
- fenoterol (2)
- fibrosis (2)
- flagella (2)
- flavonoid (2)
- flavonoids (2)
- fluid intelligence (2)
- fluorescence (2)
- food quality (2)
- forest ecology (2)
- fractal (2)
- functional magnetic resonance imaging (2)
- funding (2)
- gender differences (2)
- general population (2)
- general practitioner (2)
- genome (2)
- genome-wide association study (2)
- genomics (2)
- greenhouse gas (2)
- growing season (2)
- growth (2)
- guidelines (2)
- hCG (2)
- haemorrhage (2)
- hand hygiene (2)
- health behavior (2)
- health information exchange (2)
- health research (2)
- heart rate (2)
- heart rate variability (2)
- heartbeat detection (2)
- heat stress (2)
- helminth (2)
- hemoadsorption (2)
- hemodialysis (2)
- heparin (2)
- heritability (2)
- high-carbon behavior (2)
- high-fat diet (2)
- hip dysplasia (2)
- hirudin (2)
- holobiont (2)
- homodimerization (2)
- hospitalization (2)
- host-microbe interactions (2)
- hot melt extrusion (2)
- hydrogel (2)
- hydrophobicity (2)
- imagery (2)
- immune evasion (2)
- immune responses (2)
- immunogenicity (2)
- immunology (2)
- immunomodulatory proteases (2)
- immunoproteasome (2)
- immunoproteomics (2)
- in vitro cytotoxic activity (2)
- in vitro metabolization (2)
- in vivo (2)
- inactive nurses (2)
- incidence (2)
- inductively coupled plasma (2)
- infectious disease (2)
- influenza A virus (2)
- integrative taxonomy (2)
- interoception (2)
- intervention (2)
- intestinal nematode (2)
- intestine (2)
- invasive (2)
- ion mass spectrometry (2)
- ionosphere (2)
- ischemia reperfusion injury (2)
- ketamine (2)
- knowledge (2)
- kynurenine pathway (2)
- landcover reconstruction (2)
- laser photodetachment (2)
- late-stage functionalisation (2)
- layer charge (2)
- lead diversification (2)
- lectin (2)
- left ventricular hypertrophy (2)
- legislative-executive relations (2)
- lexis (2)
- light variability (2)
- lipid mediators (2)
- lipids (2)
- liver disease (2)
- low back pain (2)
- lung function (2)
- lymphocyte trafficking (2)
- mTHPC (2)
- macrophages (2)
- malnutrition (2)
- mathematical modeling (2)
- mechanisms of change (2)
- medical education & training (2)
- medicinal leeches (2)
- mendelian randomization (2)
- menstrual cycle (2)
- mesenchymal stromal cells (2)
- meta-analysis (2)
- metabolic syndrome (2)
- metal substitution (2)
- metastasis (2)
- methane (2)
- methicillin-resistant (2)
- methylation (2)
- micro-site (2)
- microRNA (2)
- microarray (2)
- microbial diversity (2)
- microglia (2)
- microwave interferometry (2)
- mode transition (2)
- molecular (2)
- molecular docking (2)
- monitoring (2)
- moral motivation (2)
- motility (2)
- mouse (2)
- multi-omics (2)
- multidrug resistance (MDR) (2)
- music (2)
- musicians (2)
- myeloid-derived suppressor cells (2)
- myocardial infarction (2)
- nanoemulsion (2)
- necrotizing soft tissue infections (2)
- negative ions (2)
- nervous system (2)
- network (2)
- neurodegeneration (2)
- neuroinflammation (2)
- neurology (2)
- neuronal plasticity (2)
- neurons (2)
- next-generation sequencing (2)
- nitric oxide (2)
- non-alcoholic fatty liver disease (2)
- non-motor manifestation (2)
- non-small cell lung cancer (2)
- nursing (2)
- nursing shortage (2)
- nutrient supply (2)
- obstructive sleep apnea (2)
- older adults (2)
- ontogeny (2)
- oral contraceptives (2)
- order pattern (2)
- organic cation transporter (2)
- organic supplements (2)
- osteoporosis (2)
- osteosarcoma (2)
- overweight (2)
- oxidation (2)
- oxygen (2)
- oxygen consumption (2)
- paclitaxel (2)
- pain management (2)
- palliative care (2)
- palynology (2)
- paratuberculosis (2)
- participatory research (2)
- partisan theory (2)
- pathogenicity (2)
- pathology (2)
- patient preferences (2)
- patient-centered care (2)
- peatlands (2)
- peptide sharing (2)
- perceived stress (2)
- percolation fen (2)
- periodontal therapy (2)
- periodontal treatment (2)
- peritoneal B cells (2)
- perivascular adipose tissue (2)
- persistent depressive disorder (2)
- pharmacokinetics (2)
- phosphoproteomics (2)
- photodynamic therapy (2)
- photosynthesis (2)
- phytoplankton (2)
- plasma (2)
- plastic degradation (2)
- platelet activation (2)
- pneumolysin (2)
- podocyte (2)
- pollen dispersal (2)
- pollen productivity estimates (2)
- population-based imaging (2)
- populism (2)
- pore-forming toxins (2)
- positron beam (2)
- pre-mRNA (2)
- precision medicine (2)
- predation (2)
- predictors (2)
- preterm birth (2)
- primary care (2)
- primary school children (2)
- protection (2)
- protein (2)
- protein abundance (2)
- protein aggregation (2)
- protein expression (2)
- proteomic analysis (2)
- proteostasis (2)
- psychotherapy (2)
- public awareness (2)
- pulmonary arterial hypertension (2)
- pulmonary hypertension (2)
- pulse wave analysis (2)
- quality control (2)
- radical prostatectomy (2)
- randomised trials (2)
- randomized controlled trial (2)
- range expansion (2)
- rare diseases (2)
- reactive nitrogen species (2)
- real-time PCR (2)
- reappraisal (2)
- record linkage (2)
- recovery (2)
- redox regulation (2)
- regeneration (2)
- regional differences (2)
- regulatory networks (2)
- remote sensing (2)
- resource competition (2)
- respiratory infection (2)
- resting state fMRI (2)
- resting-state functional connectivity (2)
- retinopathy of prematurity (2)
- return (2)
- riociguat (2)
- risk factors (2)
- robot (2)
- sanitary facilities (2)
- sarcoma (2)
- school engagement (2)
- scoping review (2)
- secondary school (2)
- secretome (2)
- seizures (2)
- self-assembly (2)
- sensorimotor cortex (2)
- serine protease (2)
- sex differences (2)
- shiver (2)
- signal processing (2)
- signaling (2)
- simulation (2)
- site selection (2)
- skin cancer (2)
- skin infections (2)
- smoking (2)
- social interactions (2)
- sodium bituminosulfonate (2)
- soil (2)
- solar EUV (2)
- spatial cognition (2)
- spatial representation (2)
- species diversity (2)
- sperm transfer (2)
- sphingolipids (2)
- sphingomyelin (2)
- spiders (2)
- split structure (2)
- stable isotope (2)
- statistical methods (2)
- stem cells (2)
- stiffness (2)
- stigma (2)
- stress response (2)
- stroke rehabilitation (2)
- structure (2)
- structure-activity (2)
- study protocol (2)
- subterranean estuary (2)
- sulfasalazine (2)
- sulfur (2)
- supercritical fluid chromatography (2)
- superposed epoch analysis (2)
- suppression (2)
- surface modification (2)
- surgery (2)
- survival analysis (2)
- sustainability (2)
- symbiosis (2)
- symptoms (2)
- systematic review (2)
- tafazzin (2)
- targeted therapy (2)
- taste (2)
- taxonomy (2)
- teachers (2)
- telomere length (2)
- thrombocytopenia (2)
- titin (2)
- toll-like receptor 4 (2)
- toxicity (2)
- transaminases (2)
- transcranial electrical stimulation (2)
- transcranial magnetic stimulation (2)
- transcription factor EB (2)
- transmission (2)
- transplantation (2)
- transporter (2)
- trauma (2)
- treeline ecotone (2)
- tropical forests (2)
- tuberculosis (2)
- tumours (2)
- turbulence (2)
- two-component system 09 (2)
- utilization (2)
- vagal tone (2)
- vagus nerve (2)
- vegetation history (2)
- virology (2)
- virulence factors (2)
- vision (2)
- volatile organic compound (2)
- voxel-based morphometry (2)
- warning message (2)
- well-being (2)
- wetlands (2)
- whole-body magnetic resonance imaging (2)
- wildlife (2)
- wood anatomy (2)
- xylem anatomy (2)
- xylogenesis (2)
- zooplankton (2)
- β-lactam antibiotics (2)
- (high-throughput) aldehyde detection (1)
- (moral) emotions (1)
- -amino acid oxidase (LAAO) (1)
- -anethole (1)
- 1,1-Dehydration (1)
- 1,2,3-benzotriazoles (1)
- 1,2,4-triazoles (1)
- 1,3,5-triazines (1)
- 1,4-naphthoquinones (1)
- 1-MT (1)
- 10-year follow-up (1)
- 11β-HSD1 (1)
- 16S rDNA amplicon sequencing (1)
- 16S rRNA (1)
- 16S rRNA gene-sequencing (1)
- 16S sequencing (1)
- 17-AAG (1)
- 18S rRNA (1)
- 2 (1)
- 2,4-diamino-1,3,5-triazines (1)
- 2-Phenoxyethanol (1)
- 2-imino-2 (1)
- 2-imino-2<i>H</i>-chromen-3-yl-1,3,5-triazines (1)
- 2-imino-coumarins (1)
- 2-iminocoumarins (1)
- 2-thiolation (1)
- 25‐Hydroxyvitamin D 2 (1)
- 2<i>H</i>-chromen-3-yl-1,3,5-triazines (1)
- 2D PAGE (1)
- 3,5-Diiodothyronine (1)
- 3,5-diiodothyronine (1)
- 33C10 (1)
- 3D model (1)
- 3D reconstruction (1)
- 3D visualization (1)
- 3D-QSAR (1)
- 3D-printing (1)
- 4 (1)
- 4D flow MRI (1)
- 5-fluorouracil (1)
- 52.27.Lw (1)
- 52.50.Dg (1)
- 52.65.-y (1)
- 52.75.Hn (1)
- 52.80.Hc (1)
- 5637 (1)
- 5‐lipoxygenase (1)
- 6-min-walk-test (1)
- 60B15 (1)
- 60H05 (primary) (1)
- 6606PDA (1)
- 7β-Hydroxylierung (1)
- 89.75.Fb (1)
- 90-day mortality (1)
- <i>A. thaliana</i> (1)
- <i>Argiope bruennichi</i> (1)
- <i>Arundo donax</i> (1)
- <i>Babesia</i> (1)
- <i>Candida lusitaniae</i> (1)
- <i>Clostridiodes difficile</i> (1)
- <i>Enterobacter</i> (1)
- <i>Enterobacteriaceae</i> (1)
- <i>Escherichia coli</i> (1)
- <i>Hermite</i>-polynomials (1)
- <i>Ixodes ricinus</i> (1)
- <i>Janus kinase 2</i> (<i>JAK2</i>) (1)
- <i>K. pneumoniae</i> (1)
- <i>Kolmogorov</i>-backward-equation (1)
- <i>Lannea barteri</i> (1)
- <i>Mycobacterium avium</i> ssp. <i>paratuberculosis</i> (MAP) (1)
- <i>Mycobacterium tuberculosis</i> (1)
- <i>N</i>-acylhydrazones (1)
- <i>N</i>-sulfonylhydrazones (1)
- <i>Phragmites australis</i> (1)
- <i>Robinia pseudoacacia</i> L. (1)
- <i>S. pneumoniae</i> (1)
- <i>SLC16A1</i> (1)
- <i>Solanum lycopersicum</i> L. (1)
- <i>Staphylococcus lugdunensis</i> (1)
- <i>Streptococcus mutans</i> (1)
- <i>Streptococcus oralis</i> (1)
- <i>Typha latifolia</i> (1)
- <i>agr</i> type (1)
- <i>lpxM</i> (<i>msbB</i>) (1)
- <i>spa</i> type (1)
- <span style="font-variant:small-caps; text-transform:lowercase">L</span>-Carnitine (1)
- ABCC8 (1)
- ABI (1)
- ABM test (1)
- ACC (1)
- ACE inhibitors (1)
- ACE2 (1)
- ADA (1)
- ADAP/SKAP1/2 (1)
- ADCC (1)
- ADEM (1)
- ADGRE1 (1)
- ADHD (1)
- ADL (1)
- ADMET analysis (1)
- ADPKD (1)
- AED (1)
- AFH (1)
- AFLP (1)
- AICC (1)
- AKT/mTOR signaling (1)
- ANC (1)
- APOE ε4 (1)
- APP (1)
- ARB (1)
- ARPES (1)
- ASDEX Upgrade (1)
- ASPS (1)
- ATA (1)
- ATP levels (1)
- ATP-binding cassette transporters (1)
- AUDIT (1)
- AUDIT-C (1)
- AUDIT‐C (1)
- AUGUSTUS (1)
- AVQI (1)
- Abdominal fat (1)
- Ability to work (1)
- Abiraterone (1)
- Absence asymmetry (1)
- Absorption (1)
- Acceptance (1)
- Acetic acid (1)
- Achaete-scute complex homolog 2 (1)
- Actinobacteria (1)
- Activator-binding domain (1)
- Actor-based typology (1)
- Acute cerebral ischemia (1)
- Acute decompensated heart failure (1)
- Acute ischaemic stroke (1)
- Acute myeloid leukemia (AML) (1)
- Acyltransfer (1)
- Acyltransferase (1)
- Adaptation (1)
- Adenocarcinoma (1)
- Administrative data (1)
- Adolescents, 12-year-olds (1)
- Adult allogeneic stem cell transplantation (1)
- Advanced nursing practice (1)
- Advanced nursing roles (1)
- Adverse consequences (1)
- Aerobic treadmill training (1)
- Affective conflict (1)
- Affymetrix (1)
- Africa (1)
- Age-related macular degeneration (1)
- AgeWell.de (1)
- Agoraphobia (1)
- Agreement (1)
- Agri-food networks (1)
- Akt (1)
- Albuminuria (1)
- Alcohol abuse (1)
- Alcohol dehydrogenase (1)
- Alignment (1)
- Alignment anchor (1)
- Alkali-activated binder (1)
- Alliances (1)
- Allogeneic blood (1)
- Allogeneic transfusion (1)
- Aluize (1)
- Alumino-silicate glass (1)
- Alzheimer (1)
- Alzheimer's (1)
- Alzheimer’s clinical syndrome (1)
- Ambulatory care (1)
- Ambulatory geriatric rehabilitation (1)
- Amine transaminase (1)
- AmpC (1)
- Amyloid-β (1)
- Analytic hierarchy process (1)
- Ang-(1-7) (1)
- Angiitis (1)
- Angiopathy (1)
- Angiotensin (1–7) (1)
- Angiotensin I-converting enzyme 2 (1)
- Animal husbandry (1)
- Animal models (1)
- Ankle-brachial index (1)
- Anthropized environments (1)
- Antibacterial efficacy (1)
- Antibacterial host defense (1)
- Antibiotic resistance (1)
- Antibiotic therapy (1)
- Antibody (1)
- Antigen suppression (1)
- Antimicrobial (1)
- Antimicrobial efficacy (1)
- Antimicrobial resistance (1)
- Antioxidants (1)
- Antioxidative system (1)
- Antisepsis (1)
- Antiseptic (1)
- Antiseptic efficacy (1)
- Antiseptic mouth rinse (1)
- Antoxidant capacity (1)
- Anxiety (1)
- Anxiety, fear conditioning (1)
- Anyphaenidae (1)
- Aortic compliance (1)
- Apnea–hypopnea index (1)
- ApoE-KnockOut (1)
- Apolipoprotein E knockout mice (1)
- Apolipoprotein concentration (1)
- Apoptosis (1)
- Approximate Bayesian Computation (1)
- Araceae (1)
- Araneoidea (1)
- Archaeidae (1)
- Arcuate body (1)
- Aristolochic acid I (1)
- Armenia (1)
- Aromatic Diamine (1)
- Arterial dissection (1)
- Arvicolinae (1)
- Aryl fluorides (1)
- Ascorbate–glutathione cycle (1)
- Asia (1)
- Aspiration (1)
- Asymmetric internal genitalia (1)
- Atmospheric pressure plasma (1)
- Atomic absorption spectrometry (1)
- Attention (1)
- Attitudes (1)
- At‐risk Drinking (1)
- Austrophasmatidae (1)
- Authigenic carbonates (1)
- Autism spectrum disorder (1)
- Auto-anti-D (1)
- AutoCart (1)
- Autoantibodies (1)
- Autofluorescence (1)
- Autoimmune pancreatitis (1)
- Autoimmunity (1)
- Automated monitoring (1)
- Auxiliary activity (1)
- Azides (1)
- Azonal vegetation (1)
- B cell class switch (1)
- B cell response (1)
- B-1a B cells (1)
- B1 B cells (1)
- BA.2 (1)
- BA.5 (1)
- BDNF (1)
- BDNF (brain-derived neurotrophic factor) (1)
- BISCWIT (1)
- BK polyomavirus (1)
- BK-associated hemorrhagic cystitis (1)
- BK-virus (1)
- BMD (1)
- BMI (1)
- BRAF (1)
- BRAFV600E mutation (1)
- BRAFi-resistance (1)
- Baboon (1)
- Bacillus cereus (1)
- Bacillus cereus biovar anthracis (1)
- Bacillus licheniformis (1)
- Bacillus subtilis (1)
- Bacteria (1)
- Bacterial infection (1)
- Bacterial vaginosis (1)
- Baeyer-Villiger monooxygenase (1)
- Bakterien (1)
- Balanced cross sections (1)
- Baltic Sea region (1)
- Basic concepts (1)
- Bayesian (1)
- Bayesian animal model (1)
- Bayesian sparse linear mixed model (1)
- Bayesian statistics (1)
- Bayley scales (1)
- Bdf1 (1)
- Bechstein’s bat (1)
- Benchmark material (1)
- Benign breast tumours (1)
- Bergmann's rule (1)
- Bergmann’s rule (1)
- Berlin Brandenburg Airport (1)
- Bgl (1)
- Bias (1)
- Biatain Ag (1)
- Bidirectional electron transfer (1)
- Bidirectional in-/direct external electron transfer (1)
- Big Data (1)
- Big Five (1)
- Binaural beats (1)
- Bioavailability (1)
- Biocidal product regulation (1)
- Biocomputational metho (1)
- Biodiversity (1)
- Biodiversity assessment (1)
- Bioelectrochemistry (1)
- Biomarkers (1)
- Biomechanics (1)
- Biopsychosocial causal model (1)
- Biorefinery process (1)
- Birth length (1)
- Birth weight (1)
- Bland-Altman Plots (1)
- Bleeding (1)
- Blood coagulation (1)
- Blood donation (1)
- Blood donor questionnaire (1)
- Blood donors (1)
- Blood safety (1)
- Blood transfusion (1)
- Blue Intensity (1)
- Bodian staining (1)
- Body fat (1)
- Body size (1)
- Bone fracture (1)
- Bone marrow metastasis (1)
- Border (1)
- Borderline personality disorder (1)
- Brachionus (1)
- Brain evolution (1)
- Brain health (1)
- Brainstem (1)
- Brainstem ischemia (1)
- Brainstem perforators (1)
- Brazil (1)
- BrdU (1)
- Breast milk (1)
- Brief intervention (1)
- Broad consent (1)
- Bronchopulmonary dysplasia (1)
- Buneman theorem (1)
- Burkholderia pseudomallei (1)
- Burnout (1)
- Business models (1)
- Bystander resuscitation (1)
- C-F activation (1)
- C. difficile (1)
- CAL 78 (1)
- CAM (1)
- CANDLE/PRAAS (1)
- CASP (1)
- CAZyme (1)
- CAZymes (1)
- CAZymes formaldehyde detoxification (1)
- CA–Markov (1)
- CBASP (1)
- CC88 (1)
- CCHC zinc finger (1)
- CCK1R binding (1)
- CCL17 (1)
- CCL22 (1)
- CCM1 (1)
- CCM1/KRIT1 (1)
- CCR2 (1)
- CD13 (1)
- CD40L (1)
- CD83 (1)
- CFTR Cl (1)
- CGRP (1)
- CHI (1)
- CKD—chronic kidney disease (1)
- CLP (1)
- CNS (1)
- CNS—central nervous system (1)
- CNV analyses (1)
- COPD (1)
- COVID (1)
- COVID-19-related future anxiety (1)
- COVID19 (1)
- CPET (1)
- CPR (1)
- CRAFFT (1)
- CRE-ER/lox (1)
- CRISPR-Cas (1)
- CRISPR/Cas (1)
- CS molecular absorption (1)
- CT (1)
- CTLA-4 (1)
- CTX-M-1 (1)
- CVD biomarker (1)
- CYP1A1 (1)
- CYP1A2 (1)
- CYP2C19 (1)
- CYP2D6 (1)
- Callosal tract (1)
- Calu-3 (1)
- Cambodia (1)
- Cancer (1)
- Cancerogenesis (1)
- Candida (1)
- Cantor dust (1)
- Cantor set (1)
- Carbenes (1)
- Carbohydrate metabolism (1)
- Carbon isotopes (1)
- Carbonate microfacies (1)
- Carboniferous sequence (1)
- Cardiac arrest (1)
- Cardiopulmonary resuscitation (1)
- Cardiorespiratory fitness (1)
- Cardiovascular rehabilitation (1)
- Cardiovascular risk factors (1)
- Care and case management (1)
- Career choice (1)
- Carex acutiformis (1)
- Carex rostrata (1)
- Caries activity (1)
- Caries decline (1)
- Caries prevalence (1)
- Caries prevalence (1)
- Caries risk (1)
- Caries treatment (1)
- Caries trends (1)
- Cariology (1)
- Carotid arteries (1)
- Cascade reaction (1)
- Case report (1)
- Catalytic Activity (1)
- Catchment area (1)
- Caucasus (1)
- Cell biophysics (1)
- Cell culture (1)
- Cell cultures (1)
- Cell death (1)
- Cell mechanics (1)
- Cell processes and subcellular processes (1)
- Cell surface molecules (1)
- Cells (1)
- Cellulose (1)
- Cementless THA (1)
- Centaurothamnus maximus (1)
- Central sensitization (1)
- Centrality (1)
- Cephalopoda (1)
- Cerebral angiogram (1)
- Cerebral infarcts in young adults (1)
- Cerebral ischaemia (1)
- Cerebral palsy (1)
- Cerebrovascular disease (1)
- Cerulein (1)
- Cetuximab (1)
- ChREBP (1)
- Chagas’ disease (1)
- Changane (1)
- Change agents (1)
- Changes in environmental salinity (1)
- Characteristic Attribute Organization System (1)
- Charge simulation method (1)
- Chelicerata (1)
- Chemoresistance (1)
- Chemostatic processes (1)
- Childhood abuse (1)
- Children Born of War (1)
- Child–Pugh score (1)
- Chimpanzee (1)
- Chlorhexidine digluconate (1)
- Cholestasis (1)
- Chondrichthyes (1)
- Chromosomal aberrations (1)
- Chromosome 7q31-q36 (1)
- Chronic liver disease (1)
- Chronic non-communicable diseases (1)
- Chronic obstructive pulmonary disease (1)
- Chronic pancreatitis (1)
- Chronic thromboembolic pulmonary hypertension (1)
- Circular economy (1)
- Cisplatin (1)
- Citizen first responder (1)
- Citrus fruits (1)
- Claims data (1)
- Clay mineral diagenesis (1)
- Click chemistry (1)
- Climate Change (1)
- Clinical procedure (1)
- Clinical trial (1)
- Clinical trials (1)
- Clinimetrics (1)
- Clonal growth (1)
- Clostridioides difficile (1)
- Clp proteases (1)
- Clp proteolysis (1)
- Co-culture (1)
- Co-selection (1)
- CoFeB (1)
- CoViD-19 protective mask (1)
- Coactivator (1)
- Cobalt (1)
- Cochlear implant (1)
- Cochrane–Orcutt procedure (1)
- CofP (1)
- Cognition (1)
- Cognitive control (1)
- Cognitive ergonomics (1)
- Cognitive-behavioral therapy (1)
- Colaizzi (1)
- Cold atmospheric plasma (1)
- Cold atmospheric pressure plasma (1)
- Cold physical plasma (1)
- Cold plasma (1)
- Collaborative care (1)
- Collaborative knowledge production (1)
- Colonization (1)
- Combination chemotherapy (1)
- Common Tern (1)
- Common bile duct ligation (1)
- Communication science (1)
- Community dentistry (1)
- Community first responder (1)
- Compatibility (1)
- Complement (1)
- Complex regional pain syndrome (1)
- Complexity (1)
- Complication (1)
- Compositional data analysis (1)
- Compression (1)
- Computational fluid dynamic simulations (1)
- Computer simulation (1)
- Concentration (1)
- Conditioning therapy (1)
- Conformal map (1)
- Congestion (1)
- Coniopterygidae (1)
- Connectivity (1)
- Consent implementation (1)
- Consent management (1)
- Consent process (1)
- Conservation (1)
- Continuous electrosynthesis (1)
- Continuum (1)
- Continuum beliefs (1)
- Control (1)
- Corepressor (1)
- Coronavirus (1)
- Corpus linguistics (1)
- Correlation networks (1)
- Cortical thickness (1)
- Cortisol (1)
- Cost (1)
- Cost-effectiveness (1)
- Cranes (1)
- Creighton’s principles (1)
- Crete (1)
- Crisis communication (1)
- Cristina Lafont (1)
- Critical illness myopathy (1)
- Cross-border healthcare (1)
- Cross-lagged panel model (1)
- CyberKnife robotic radiosurgery (1)
- Cybermobbing (1)
- Cyc8 (1)
- Cyclooxygenase-2 (1)
- Cyprus (1)
- Cystic lesion (1)
- Cytochrom P450 Monooxygenase (1)
- Cytokine secretion (1)
- Cytoprotection (1)
- C–C bond cleavage (1)
- DDH (1)
- DDR (1)
- DDT (1)
- DEB-model (1)
- DHEAS (1)
- DISQOVER (1)
- DIT (1)
- DLC1 (1)
- DLX proteins (1)
- DNA damage (1)
- DNA damage response (1)
- DNA degradation (1)
- DNA epair (1)
- DNA extraction bias (1)
- DNA preservation (1)
- DNA quality index (1)
- DNA taxonomy (1)
- DNA-barcoding (1)
- DNAzyme (1)
- DNA–DNA hybridization (ddH) (1)
- DOT-MGA (1)
- DSB (1)
- DUBs (1)
- DUOCAP (1)
- DWI (1)
- Daratumumab (1)
- Dark Ages Cold Period (DACP) (1)
- Dark Future Scale for children (1)
- Data and biomaterial collection (1)
- Daubenton’s bats (1)
- De- and remineralisation (1)
- Dear Doctor letter (1)
- Decision-making (1)
- Deferral (1)
- Degradation (1)
- Dehydrogenation (1)
- Delayed recovery (1)
- Delegation (1)
- Democratic Republic of the Congo (DRC) (1)
- Demography (1)
- Dendritic cells (1)
- Dental education (1)
- Dental fluorosis (1)
- Dental implant (1)
- Dental sleep medicine (1)
- Dentin caries (1)
- Denture (1)
- Depressive symptoms (1)
- Determinism (1)
- Deutsche Version des School Burnout Inventory (1)
- Developmental risks (1)
- Diabetes mellitus (1)
- Diabetic retinopathy (1)
- Diagnosis (1)
- Diagnostic criteria (1)
- Diagnostic test (1)
- Diagnostics (1)
- Diauxie (1)
- Dielectric barrier discharge (1)
- Dietary behavior (1)
- Diffraction (1)
- Diffuse congenital hyperinsulinism (1)
- Digestive system (1)
- Digital health (1)
- Digital ion trap (1)
- Dinosauria (1)
- Dipteran vector (1)
- Dirac-cone physics (1)
- Disability (1)
- Disease management (1)
- Disease vector (1)
- Dispatcher-assisted CPR (1)
- Dispersion function (1)
- Dissection (1)
- Disseminated intravascular coagulation (1)
- Dissemination (1)
- Dissociation (1)
- Distance decay effect (1)
- Distribution (1)
- Docetaxel (1)
- Donor return behavior (1)
- Donor selection (1)
- Donors (1)
- Drinking Patterns (1)
- Drishti (1)
- Drone (1)
- Dropout (1)
- Drosera intermedia (1)
- Drosera rotundifolia (1)
- Drug (1)
- Drug release (1)
- Drug resistance (1)
- Drug stability (1)
- Drug transport (1)
- Dual-task (1)
- Duchenne (1)
- Ductoscopy (1)
- Dust acoustic waves (1)
- Dyes (1)
- Dyslipidemia (1)
- Dysphagia (1)
- Dysphonia (1)
- Dyspnea (1)
- E3 ligases (1)
- EEG/ERP (1)
- EGFR inhibitor (1)
- EGFR-mutated (1)
- EKG (1)
- ELISA (1)
- EMP-hybrid (1)
- EMR1 (1)
- EMSA (1)
- EMT (1)
- EPIDEMIOLOGY (1)
- EPR spectroscopy (1)
- ER stress (1)
- ER-stress (1)
- ERK (1)
- ERK1/2 (1)
- ESBL – (1)
- ESBL/AmpC- (1)
- ESBL— (1)
- ESKAPE pathogens (1)
- ESKAPE strain (1)
- ET (1)
- EU Water Framework Directive (1)
- Early Jurassic (1)
- Early childhood caries (1)
- Early mobilization (1)
- Early prevention (1)
- Ecosystem services (1)
- Ecotype (1)
- Ectoparasite (1)
- EdU (1)
- Education (1)
- Effectiveness of telemedicine treatment (1)
- Effects of blood donation (1)
- Efficacy (1)
- Eggshells (1)
- Elav (1)
- Elderly (1)
- Elective surgery (1)
- Electroanalysis (1)
- Electrochemical Synthesis (1)
- Electrochemistry (1)
- Electrodes of second kind (1)
- Electroencephalography (1)
- Electrofuel (1)
- Electronic assessment (1)
- Elimination (1)
- Ellenberg indicator values (1)
- Emergency medical care (1)
- Emergency medical dispatch (1)
- Emergency medical service (1)
- Emerging adults (1)
- Employment (1)
- Encephalitis (1)
- Endoscopic breast ductoscopy (1)
- Endoscopic third ventriculostomy (1)
- Energy mobilization (1)
- Energy supply (1)
- Enteral nutrition (1)
- Enterobacterales (1)
- Enterobacteriaceae (1)
- Environmental Economics (1)
- Environmental and Conservation Psychology (1)
- Environmental risk factors (1)
- Environmental toxins (1)
- Enzyme Cascade (1)
- Enzyme Catalysis (1)
- Eocene (1)
- Epidemiology of pediatric emergencies (1)
- Epilepsy (1)
- Epithelioid sarcoma (1)
- Epitopes (1)
- Equity (1)
- Erucic acid (1)
- Escherichia coli (1)
- Essential thrombocythemia (1)
- Estimated glomerular filtration rate (1)
- Ethanol based hand rub (1)
- Ethics (1)
- Ethiopia (1)
- Euregio (1)
- European Union (1)
- European soccer championship (1)
- Ewing sarcoma (1)
- ExWAS (1)
- Expectation of continuity (1)
- Experimental techniques (1)
- Exposure (1)
- Expression system (1)
- Extracellular matrix (1)
- Extrakt (1)
- Extramedullary disease (1)
- Extremism (1)
- Eye Tracking (1)
- Eye tracking (1)
- F-florbetaben PET (1)
- F1 score (1)
- F4/80 (1)
- FACIT (1)
- FAIR data (1)
- FAM159B (1)
- FAP-IL-2v (1)
- FASN (1)
- FDM (1)
- FHIR (1)
- FIA (1)
- FLT3 (1)
- FLT3-TKD (1)
- FMS-like tyrosine kinase 3 (1)
- FRET (1)
- FTIR spectroscopy (1)
- FTSJ1 (1)
- Facial expressions (1)
- Fagus sylvatica (1)
- False-male-above mating position (1)
- Familial transmission pathways (1)
- Familie-VIII-Carboxylesterase (1)
- Family (1)
- Fast multipole method (1)
- Fatty acid enrichment (1)
- Fatty tissue (1)
- Fault-related folding (1)
- FcγRIIA (1)
- FcγRIIa (1)
- FeSe (1)
- Feasibility (1)
- Fed batch (1)
- Feed supplementation (1)
- Female mate choice (1)
- Femtosecond laser (1)
- Femtosecond lasers (1)
- Fetal growth restriction (1)
- Fibrosis (1)
- Fick method (1)
- Fidaxomicin (1)
- Fiji (1)
- Filling (1)
- Financial risk protection (1)
- Fine tiling comparative genomic hybridization (1)
- Finite-element analysis (1)
- Firmicutes (1)
- First responder (1)
- First-time donors (1)
- Flavanols (1)
- Flavonols (1)
- Floreana (1)
- Flow catalysis (1)
- Flow injection potentiometry (1)
- Flow injection titration (1)
- Fluid flows (1)
- Fluidigm array (1)
- Fluoride (1)
- Focal congenital hyperinsulinism (1)
- Focused ion beam polishing (1)
- Food (1)
- Food effect (1)
- Food labeling (1)
- Food policy (1)
- Food waste (1)
- Force (1)
- Forest dieback (1)
- Forest ecology (1)
- Formula diet (1)
- Free thyroxine (1)
- Free-riding (1)
- FreeSurfer (1)
- Freshwater swamps (1)
- Function prediction (1)
- Functional health (1)
- Functional magnetic resonance imaging (1)
- Fungi (1)
- Furfural (1)
- Fused filament fabrication (1)
- Future specialists (1)
- F‐actin (1)
- G-protein-coupled oestrogen receptor (1)
- GABA (1)
- GATA-3 (1)
- GATA1 (1)
- GBIF (1)
- GBM (1)
- GD2 antibody therapy (1)
- GD2-CAR (1)
- GHG emissions (1)
- GHGs (1)
- GI hormones (1)
- GLIM (1)
- GMP (1)
- GMRES method (1)
- GPER (1)
- GPR30 (1)
- GPR68 (1)
- GPU computing (1)
- GPx1 knockout (1)
- GWA (1)
- Galectin (1)
- Galileo® (1)
- Gasdermin D (1)
- Gastric balloon (1)
- GastroDuo (1)
- Gastrointestinal oncology (1)
- Gastrointestinal stromal tumor (1)
- Gastrointestinal symptoms (1)
- Gastrointestinal tract (1)
- Gaussian beam (1)
- Gelatinase A (1)
- Gemcitabine (1)
- Gene mutation (1)
- Gene prediction (1)
- Gene repression (1)
- General outpatient palliative care (GOPC) (1)
- General population (1)
- General practitioner (1)
- Genetic counselling (1)
- Genetic differentiation (1)
- Genetics (1)
- Genital tract infection (1)
- Genome alignment (1)
- Genotype (1)
- Genotyping (1)
- Geometric hashing (1)
- Geopolymer (1)
- Geostatistics (1)
- Gerbstoff (1)
- Geriatric multimorbidity (1)
- Geriatrics (1)
- German Centre for Cardiovascular Research (1)
- German School Burnout Inventory (1)
- German and Canadian secondary school students (1)
- Gestational age (1)
- Gibbs energy (1)
- Gingival index (1)
- Glacitectonics (1)
- Glass (1)
- Glaucoma (1)
- Global South regional policy (1)
- Global warming (1)
- GlpQ (1)
- Glycine (1)
- Glycolysis (1)
- Gompertz (1)
- Gondoic acid (1)
- Graft-versus-host disease (1)
- Gram-positive infections (1)
- Granudacyn® (1)
- Gravettian (1)
- Green algae (1)
- Green chemistry (1)
- Greenhouse gases (1)
- Greenwald (1)
- Green’s function (1)
- Grimmen (1)
- Groasis Waterboxx (1)
- Gromov-Wasserstein distance (1)
- Groundwater monitoring (1)
- Group B streptococcus (1)
- Group membership (1)
- Growth curve model (1)
- Growth hormone (1)
- Guideline recommendations (1)
- H-L back transition (1)
- H. aspersa Müller (1)
- H9c2 cells (1)
- H<sub>2</sub>O<sub>2</sub> (1)
- HACA (1)
- HCC (1)
- HCH (1)
- HCM (1)
- HCO (1)
- HDAC = histone deacetylase (1)
- HDL (1)
- HEK cells (1)
- HEK293 (1)
- HIV (1)
- HLA (1)
- HLRW (1)
- HMGB1 (1)
- HNSCC (1)
- HPMC (1)
- HPTLC (1)
- HSP90 (1)
- HTLV-1 (1)
- Haemosporida (1)
- Hair follicle (1)
- Hall technique (1)
- Hand antisepsis (1)
- Hand grip strength (1)
- Hangzhou International Airport (1)
- Head and neck squamous cell carcinoma (1)
- Head injury (1)
- Health care costs (1)
- Health claims data (1)
- Health economic research (1)
- Health outcomes (1)
- Health service research (1)
- Health-related quality of life (HRQoL) (1)
- Healthcare (1)
- Healthcare use (1)
- Heart arrest (1)
- Heart rate reduction (1)
- Heart-liver axis (1)
- Heat shock protein 27 (1)
- Heavy metals (1)
- Help-seeking (1)
- Helplessness (1)
- Hemerobiidae (1)
- Hemolysis (1)
- Hemolytic anemia (1)
- Henrik Ibsen (1)
- HepG2 (1)
- Heteroplasmy (1)
- Heterostructures (1)
- HiPIMS (1)
- Hibernation phenology (1)
- Hibernation timing (1)
- Highly porous structure (1)
- Himalayan Silver Fir (<i>Abies spectabilis</i>), Nepal Himalaya (1)
- Hippocampus (1)
- Hirudin-like factors (1)
- Hirudinaria manillensis (1)
- Hirudin‐like factors (1)
- Histamine (1)
- Holarctic distribution (1)
- Holocene climate change (1)
- Hordeum vulgare (1)
- Host specificity (1)
- Human interleukin-1β (1)
- Human papilloma virus (1)
- Human thrombospondin-1 (1)
- Hybodontiformes (1)
- Hydrated Carbenes (1)
- Hydrocephalus (1)
- Hydrochemistry (1)
- Hydroxytyrosol (1)
- Hyperthyroidism (1)
- Hypochlorite (1)
- Hypochlorous acid (1)
- Hypoglycemia (1)
- Hysteresis (1)
- IADL (1)
- ICER (1)
- ICU‐acquired weakness (1)
- IDO (1)
- IDO1 (1)
- IL-10 (1)
- IL-15 (1)
- IL-18 (1)
- IL-6 (1)
- IL10 (1)
- IQ (1)
- IR-induced variants (1)
- IS<i>Kpn74</i> (1)
- ISOLDE/CERN (1)
- ISP (1)
- IT infrastructure (1)
- Ibbenbüren anthracite coal mine (1)
- Idiopathic duct-centric pancreatitis (1)
- IgG (1)
- IgM (1)
- Ilastik (1)
- Ili River delta (1)
- Illite morphology (1)
- Image macros (1)
- Imaging features (1)
- Immature mating (1)
- Immediate dental implant loading (1)
- Immune dysfunction (1)
- Immune system (1)
- Immunmodulation (1)
- Immunoadsorption (1)
- Immunocompetent mice (1)
- Immunometabolism (1)
- Immunosuppression (1)
- Implant surface (1)
- Imprinting (1)
- In vivo imaging (1)
- In vivo laser scanning microscopy (1)
- In-office aligner (1)
- Inactivation (1)
- IncI1 (1)
- IncN (1)
- Incapacity to work (1)
- Incompatibilism (1)
- Incremental cost-effectiveness ratio (1)
- Indications (1)
- Individualization (1)
- Indocyanine green videoangiography (1)
- Infant (1)
- Infected necrosis (1)
- Infection control (1)
- Inferior vena cava (1)
- Inflammation-induced muscle atrophy (1)
- Inflammatory biomarkers (1)
- Informed Consent (1)
- Initially deferred donors (1)
- Innate immunity (1)
- Innate lymphoid cells (1)
- Inpatient cancer care (1)
- Instrumentation for FEL (1)
- Instrumentation for radioactive beams (fragmentation devices, fragment and isotope, separators incl. ISOL, isobar separators, ion and atom traps, weak-beam diagnostics, radioactive-beam ion sources) (1)
- Insulin signaling (1)
- Intellectual disability (1)
- Intelligenz (1)
- Interaction specificity (1)
- Interdisciplinarity (1)
- Interfaces (1)
- Interleukin-1 (1)
- Interleukin-37 (1)
- Interleukin-4 (1)
- Interleukin-6 (1)
- International (1)
- Internet (1)
- Internet addiction (1)
- Internet memes (1)
- Internet survey (1)
- Intracellular localization (1)
- Intracerebral haemorrhage (1)
- Intraductal lesion (1)
- Intraventricular hemorrhage (1)
- Invasive cardiopulmonary exercise testing (1)
- Iodine status (1)
- Iodophors (1)
- Ion insertion (1)
- Ion pumps (1)
- Ion-sensitive electrodes (ISE) (1)
- Ischaemic stroke (1)
- IsdB (1)
- Isoflavones (1)
- Ivabradine (1)
- JAK2V617F (1)
- Jet ventilation (1)
- Jewish apocalypticism (1)
- Joachim Lelewel (1)
- Journal (1)
- Juliusz Slowacki (1)
- Jurassic (1)
- K-ras (1)
- KCNJ11 (1)
- KHV (1)
- KHVD (1)
- KIDSCREEN-10 (1)
- KRAS (1)
- KREC (1)
- KV7 (1)
- KYNA (1)
- KYSE 70 (1)
- Kaolinite melting (1)
- Kazal inhibitor (1)
- Kerr microscopy (1)
- Kidney disease (1)
- Kimmeridgian (1)
- Kinetics (1)
- Kip1 (1)
- Knoevenagel ligation (1)
- Kognitive Ergonomie (1)
- Kolbe reaction (1)
- Komplexität (1)
- Kv 7.2/3 channel activators (1)
- Kv1.3 potassium channel (1)
- K−12 teachers (1)
- L-SNEDDS (1)
- L-type Ca (1)
- LA-, HA-MRSA (1)
- LAG-3 (1)
- LAMS (1)
- LC-MS (1)
- LDL (1)
- LIPSS (1)
- LMO1 (1)
- LMP (1)
- LNCaP (1)
- LPS (1)
- LPXTG (1)
- LUCC (1)
- Label-free quantification (1)
- Laboratory procedures (1)
- Lactate (1)
- Ladder of Jacob (1)
- Lagrangian stochastic model (1)
- Lakes (1)
- Laminar flows (1)
- Land art (1)
- Landsat Time series analysis (1)
- Landscape (1)
- Langmuir probe (1)
- Langmuir probe diagnostics (1)
- Langmuir-Blodgett and Schaefer techniques (1)
- Language evolution (1)
- Late Jurassic (1)
- Late Pleistocene (1)
- Late-Holocene (1)
- Lateral flow (1)
- Latin America (1)
- Latvia (1)
- Layer height (1)
- Learning (1)
- Left ventricular geometry and function (1)
- Left ventricular hypertrophy (1)
- Left ventricular mass (1)
- Left–right dimension (1)
- Legal requirements (1)
- Lemniscatic domain (1)
- Lemnoideae (1)
- Lenticule extraction (1)
- LepB (1)
- Leptin (1)
- Lexicometric analyses (1)
- LiDAR (1)
- Life course (1)
- Life support care (1)
- Ligand-Ligand Cooperativity (1)
- Ligation-mediated PCR (1)
- Light-level geolocation (1)
- Lipid metabolism (1)
- Lipidomics (1)
- Lipolysis (1)
- Lipoprotein particles (1)
- Lipoprotein subclasses (1)
- Lithocholsäure (1)
- Little Ice Age (1)
- Liver (1)
- Liver volume (1)
- Local adaptation (1)
- Lockdown (1)
- Logical truth (1)
- Long-COVID (1)
- Longevity (1)
- Loudness scaling (1)
- Lower Toarcian (1)
- Lymphoblastic leukaemia (1)
- Lymphoplasmacytic sclerosing pancreatitis (1)
- L–H transition (1)
- M protein (1)
- M1 macrophage (1)
- M2 macrophage (1)
- M2 macrophages (1)
- MALDI-TOF (1)
- MALDI-TOF MS (1)
- MALDI-TOF mass spectrometry (1)
- MAR (1)
- MCI (1)
- MCP-1 (1)
- MDD (1)
- MDR (1)
- MDRE (1)
- MDRO (1)
- MDSC (myeloid-derived suppressor cell) (1)
- MDSCs (1)
- MENTAL HEALTH (1)
- MF (1)
- MG-63 (1)
- MHC (1)
- MHC class I (1)
- MIMIC model (1)
- MKL1 (1)
- MLST 5 (1)
- MMP-9 (1)
- MMP2 (1)
- MNAR (1)
- MNT-1 (1)
- MODIS (1)
- MODS (1)
- MPN (1)
- MRG (1)
- MRI study (1)
- MRI targeted prostate biopsy (1)
- MRI-proton-density-fat-fraction (PDFF) (1)
- MRSA - Methicillin-resistant (1)
- MRTF (1)
- MRZ reaction (1)
- MSCRAMM (1)
- MSFD (1)
- MSSA (1)
- MTIP planning (1)
- Machine Learning (1)
- Macrococcus (1)
- Madden-Julian Oscillation (1)
- Malaria (1)
- Male genitalia (1)
- Malignant transformation (1)
- Mammography (1)
- Management (1)
- Mandibular advancement device (1)
- Marangoni flow (1)
- Marine polysaccharide (1)
- Marketing (1)
- Marmoset (1)
- Mas receptor (1)
- Mass spectrometers (1)
- Mass spectrometry (1)
- Massive Analysis of cDNA Ends (MACE) (1)
- Mastication (1)
- Matched cohortstudy (1)
- Maternal pre-pregnancy overweight and obesity (1)
- Maternal pre-pregnancy underweight (1)
- Mathematical bioscience (1)
- McsB arginine kinase (1)
- Measurement (1)
- Measurement error (1)
- Measuring techniques (1)
- Mechanical properties (1)
- Mechanical stress (1)
- Mecklenburg-Western Pomerania (1)
- Medial patella maltracking (1)
- Mediation analysis (1)
- Medical data management (1)
- Medical device (1)
- Medical treatment (1)
- Medicinal leeches (1)
- Medienbildung (1)
- Mediennutzungsethik (1)
- Medieval Climate Anomaly (1)
- Medieval Climate Anomaly (MCA) (1)
- Mediterranean (1)
- Melanoma (1)
- Memorandum (1)
- Memory (1)
- Mendelian Randomization Analysis (1)
- Mendelian randomization (1)
- Mental Pain Questionnaire (1)
- Mental health problems (1)
- Mental pain (1)
- Mental problems (1)
- Mental strain (1)
- Mental stress (1)
- Mental workload (1)
- Mentale Beanspruchung (1)
- Mercury compounds (1)
- Metabolic myopathy (1)
- Metabolic reprogramming (1)
- Metadata standard (1)
- Metakaolin (1)
- Metanalysis (1)
- Metastasis (1)
- Methicillin-resistant (1)
- Method-comparison studies (1)
- MgsR activity (1)
- MgsR degradation (1)
- Mhealth (1)
- MiD51 (1)
- Michaelis–Menten function (1)
- Micro-computed X-ray tomography (1)
- MicroRNAs (1)
- Microbial electrochemistry (1)
- Microfluidic devices (1)
- Microfluidics (1)
- Microgravity (1)
- Microsurgery (1)
- Middle East (1)
- MidiPLexc (1)
- Migraine (1)
- Migration (1)
- Milos (1)
- MimiCol (1)
- MimiCol3 (1)
- Mini-implant (1)
- Minimally invasive diagnostics (1)
- Miniopterus (1)
- Miniprot (1)
- Mire (1)
- Mitigation (1)
- Mitochondrial pseudogenes (1)
- Mitochondriopathy (1)
- Mobility (1)
- Molar incisor hypomineralization (1)
- Molecular Dynamics (1)
- Molecular dynamics simulation (1)
- Molecular genetics (1)
- Money laundering (1)
- Mongolia (1)
- Monitoring (1)
- Monte Carlo (1)
- Montreal Cognitive Assessment (MoCA) (1)
- Mood (1)
- Mood regulation (1)
- Moral responsibility (1)
- Mosaicism (1)
- Mother-child disagreement (1)
- Mountain forests (1)
- Mouse cell lines (1)
- Mouse model (1)
- Multi-criteria decision analysis (1)
- Multi-level perspective (1)
- Multiparametric MRI (1)
- Multiply connected domain (1)
- Multisurface cavities (1)
- Multivariate analysis (1)
- Multivariate model (1)
- Muscle atrophy (1)
- Muscular dystrophy (1)
- Myelofibrosis (1)
- Myeloproliferative neoplasia (1)
- Myocardial infarction (1)
- Myogenic differentiation (1)
- Myotis daubentonii (1)
- Myotis nattereri (1)
- Myxopyronin B (1)
- N incorporation (1)
- N-heterocyclic carbenes (1)
- N-heterocyclic olefins (1)
- N34S (1)
- NADPH oxidases (NOX) (1)
- NAKO (1)
- NAO (1)
- NEXT (1)
- NF-Y (1)
- NF-κB signal transduction pathway (1)
- NF‐κB (1)
- NGF (nerve growth factor) (1)
- NK cells (1)
- NLRP1 (1)
- NLRP3 (1)
- NLRP3 inflammasome (1)
- NMR metabolomics (1)
- NN414 (1)
- NOD-like receptors (1)
- NOD‐like receptors (1)
- NR3C1 (1)
- NSC59984 (1)
- NSCLC (1)
- NT‐proBNP (1)
- NUMTs (1)
- NZO mice (1)
- NaFl (1)
- Namibia (1)
- Narration of Afroditian (1)
- National survey (1)
- Natterer’s bats (1)
- Natural history (1)
- Nature conservation (1)
- Nd:YAG (1)
- Necessity (1)
- Neck dissection (1)
- Negative pressure wound therapy with the instillation of antiseptics (1)
- Neonatal outcome (1)
- Neonates (1)
- Neotropics (1)
- Nephrology (1)
- Nephrology referral (1)
- Nephropathy (1)
- Nerve cells (1)
- Nervous system (1)
- Neurodevelopmental disorder (1)
- Neurodevelopmental outcome (1)
- Neuroendocrine tumors (1)
- Neuroinflammation (1)
- Neuromuscular electrical stimulation (1)
- Neuronal plasticity (1)
- Neuropathology (1)
- Neurorehabilitation (1)
- Neurosurgery (1)
- Neutron scattering (1)
- Neutrophil extracellular traps (1)
- Nickel (1)
- Niemann–Pick disease type C1 (1)
- Nitrate (1)
- Nitric oxide (1)
- Nnucleophilic substitution (1)
- Non-Innocence Ligands (1)
- Non-enveloped viruses (1)
- Non-restorative caries treatment (1)
- Non-small cell lung cancer (1)
- Non-small cell lung cancer (NSCLC) (1)
- Non-surgical periodontal therapy (1)
- Noncovalent Interactions (1)
- Nonoperative (1)
- Nonoperative caries management (1)
- NorA (1)
- Normal phenotype (1)
- Northeast German Plain (1)
- Nox4 (1)
- Nrf2-sinaling (1)
- Nuclear magnetic resonance spectroscopy (1)
- Nucleocapsid protein (1)
- Nursing (1)
- Nutrition (1)
- Nutritional risk factors (1)
- Nycteribiidae (1)
- OAT (1)
- OATP (1)
- OCT1 Effects (1)
- OGR1 (1)
- OHCA (1)
- OLR-based MJO Index (1)
- OMI (1)
- OMOP (1)
- ONX-0914 (1)
- OSA (1)
- OSAS (1)
- Observational study (1)
- Obstructive sleep apnea (1)
- Occupational dentistry (1)
- Octenidine (1)
- Octenidine dihydrochlorid (1)
- Octenidol® md (1)
- Ocular perfusion pressure (1)
- Ocular tonometry (1)
- Offspring’s development (1)
- Offspring’s health (1)
- Offspring’s social behavior (1)
- Oligonucleotides (1)
- Olive mill wastewaters valorization (1)
- Omega-3 fatty acids (1)
- Omicron (1)
- Omnilog (1)
- Oncology (1)
- One‐pot reaction (1)
- Online communication (1)
- Ontology (1)
- Operational stability (1)
- Opuntia ficus-indica (1)
- Oral hygiene (1)
- Orcokinin (1)
- Ordinal regression (1)
- Organic soil (1)
- Orthotopic murine model (1)
- Osmoregulation (1)
- Ostdeutschland (1)
- Ostracodes (1)
- Out of hospital cardiac arrest (1)
- Out-of-Hospital cardiac arrest (1)
- Out-of-pocket (1)
- Outcomes research (1)
- Ovarian cancer (1)
- Overproduction (1)
- Overview (1)
- Oxidative burst (1)
- Oxygen (1)
- Oxygen isotopes (1)
- Oxygen supply (1)
- P,O heterocycles (1)
- P,O ligands (1)
- P-glycoprotein (1)
- P300 (1)
- P53 network (1)
- PA200 (1)
- PAEDIATRICS (1)
- PAI-1 RNA-binding protein 1 (1)
- PAM (1)
- PAO (1)
- PAR1 (1)
- PAβN (1)
- PC3 (1)
- PCA (1)
- PCLake (1)
- PDA6606 (1)
- PEF (1)
- PEG (1)
- PETase activity (1)
- PETase-like enzymes (1)
- PHMB (1)
- PHMB adsorption (1)
- PHQ-9 (1)
- PI3K (1)
- PI3K/AKT pathway (1)
- PI3K/AKT/mTOR (1)
- PID (1)
- PIM1 kinase (1)
- PKD (1)
- PLK1 inhibitors (1)
- PLZF (1)
- POSIT (1)
- POSL (1)
- PPP syndrome (1)
- PREVENTIVE MEDICINE (1)
- PROMs (1)
- PRP (1)
- PRSS1 (1)
- PSD (1)
- PSMA5 (1)
- PSMB10 (1)
- PSMB8 (1)
- PSMC5 (1)
- PSME4 (1)
- PTMs (1)
- PTW (1)
- PUBLIC HEALTH (1)
- PWV (1)
- Paced Auditory Serial Addition Test (1)
- Paediatric dentistry (1)
- Paediatric oncology (1)
- Palaearctic grassland (1)
- Paleoclimate (1)
- Palliative care (1)
- Palpimanoidea (1)
- Paludiculture (1)
- Panc02 (1)
- Pancreatic cystic lesion (1)
- Pancreatic ductal adenocarcinoma (1)
- Pancreatic surgery, complications (1)
- Pancreatic tumour (1)
- Pancreatitis (1)
- Pandemic (1)
- Panic disorder (1)
- Panton-Valentine leukocidin (1)
- Parenteral nutrition (1)
- Parenting (1)
- Paris Agreement (1)
- Parkinson's disease (1)
- Partial (1)
- Participant attrition (1)
- Particle-in-cell method (1)
- Parties (1)
- Party systems (1)
- Patella medialization (1)
- Patellofemoral osteoarthritis (1)
- Patellofemoral pain (1)
- Patent foramen ovale (1)
- Path analysis (1)
- Pathophysiological relationship (1)
- Patient participation (1)
- Patient rights (1)
- Patient safety (1)
- Patient-centered care (1)
- Patient-reported outcome measure (1)
- Patient-specific modeling (1)
- Patients (1)
- Peatland (1)
- Peatland species mapping (1)
- Pediatric (1)
- Pediatric airway management (1)
- Pediatric drug product (1)
- Pediatric emergency medicine (1)
- Pediatric emergency treatment (1)
- Pediatric inflammatory bowel disease (PIBD) (1)
- Peer review (1)
- Perception (1)
- Peri-implantitis (1)
- Perinatal infection (1)
- Periodontal medicine (1)
- Periodontitis (1)
- Peripheral arterial disease (1)
- Permissive hypercapnia (1)
- Person-centered care (1)
- Personal protective equipment (1)
- Personalized medicine (1)
- PestE (1)
- Phagocytosis (1)
- Phase transition (1)
- Phenotype (1)
- Phragmites (1)
- Phylogenetic tree (1)
- Phylogeny (1)
- Physical body warm atmospheric plasma (1)
- Physical function (1)
- Physical health (1)
- Phytochemicals (1)
- Pigment (1)
- Pigs (1)
- Pineal cyst (1)
- Pinus uncinata (1)
- Pituitary (1)
- Place (1)
- Placenta (1)
- Plaque index (1)
- Plasma (1)
- Plasma spraying (1)
- Plasma treatment in vivo (1)
- Plasma-treated water (1)
- Plasmapheresis (1)
- Plasminogen activator inhibitor 1 (1)
- Plastic (1)
- Pleistocene Europe (1)
- Pneumococcal pneumonia (1)
- Pneumolysin (1)
- Poland (1)
- Policy (1)
- Polish romantic drama (1)
- Polish–German border area (1)
- Political ideology (1)
- Poly (hexamethylene biguanide) hydrochloride (PHMB) (1)
- Poly(Vinyl Alcohol) (1)
- Poly(hexamethylene)biguanide (1)
- Polychromophilus (1)
- Polyether Polyol (1)
- Polyhexamethylene biguanide (1)
- Polymorphism (1)
- Polymorphisms (1)
- Polynomial pre-image (1)
- Polyurethane (1)
- Pomalidomide (1)
- Poorly soluble drugs (1)
- Population-based study (1)
- Porcine corneal lenticules (1)
- Pore-size distributions (1)
- Porphyran (1)
- Posterior circulation (1)
- Postpartum period (1)
- Posturomed® (1)
- Potato industry (1)
- Powder (1)
- Precision medicine (1)
- Precision medicine program (1)
- Preferred Reporting Items for Systematic Reviews and Meta-Analyse (1)
- Pregnant women (1)
- Preneoplasia (1)
- Prentice model (1)
- Preschool (1)
- Preschools (1)
- Preterm infants (1)
- Prevention of cardiovascular diseases (1)
- Prevention of metabolic diseases (1)
- Primate evolution (1)
- Private practice (1)
- Processing conflict account (1)
- Prodigy (1)
- Prolonged sitting (1)
- Promiscuous acyltransferase (1)
- Promoter methylation (1)
- Propensity score matching (1)
- Prospective physician (1)
- Prospero (1)
- Prostheses and implants (1)
- Protease deficiency (1)
- Proteasome inhibitor (1)
- Protein coding gene (1)
- Protein secretion (1)
- Protein-Engineering (1)
- Proteobacteria (1)
- Protestantismus (1)
- Protocols & guidelines (1)
- Protocol‐based physiotherapy (1)
- Psychiatric outpatients (1)
- Psychiatry (1)
- Psychometric properties (1)
- Pt(II) complexes (1)
- Public Health (1)
- Publishing (1)
- Pulmonary hypertension (1)
- Push–pull imines (1)
- Python (1)
- QUALI (1)
- Quadrupole mass filter (1)
- Qualitative research (1)
- Quality (1)
- Quality in health care (1)
- Quality indicators (1)
- Quality of Life (1)
- Quality-adjusted life years (1)
- Quantitative light-induced fluorescence (1)
- R programming (1)
- R project for statistical computing (1)
- R. chamaemorus (1)
- R122H (1)
- RAAS (1)
- REVEALS (1)
- RF mass Spectrometry (1)
- RFamide (1)
- RIDD (1)
- RMSSD (1)
- RNA engineering (1)
- RNA polymerase inhibitors (1)
- RNA recombination (1)
- RNA-seq (1)
- RNAlater (1)
- ROC analysis (1)
- ROP (1)
- ROP screening (1)
- ROXAS (1)
- RPE (1)
- RRID: AB_2338006 (1)
- RRID: AB_2338362 (1)
- RRID: AB_2338459 (1)
- RRID: AB_2338914 (1)
- RRID: AB_2341179 (1)
- RRID: AB_261811 (1)
- RRID: AB_477585 (1)
- RRID: SCR_007370 (1)
- RRID: SCR_010279 (1)
- RRID: SCR_014199 (1)
- RRMM (1)
- RV (1)
- Radicalisation (1)
- Raman Spectroscopy (1)
- Raman spectroscopy (1)
- RareScreen (1)
- Rasch (1)
- Reactive oxygen and nitrogen species (1)
- Reactive oxygen species (1)
- Reactive oxygen species (ROS) (1)
- Reactive thin films (1)
- Reactive transport (1)
- Real-world data (1)
- Received Pronunciation (1)
- Reckless driving (1)
- Recombinant guanine deaminase (1)
- Reconstructed human epidermis (1)
- Recurrence (1)
- Recurrent depression (1)
- Red blood cell concentrate (1)
- Red blood cell concentrates (1)
- Redox Chemistry (1)
- Redox signaling (1)
- Referral (1)
- Registries (1)
- Registry (1)
- Reiber’s diagram (1)
- Reliability (1)
- Remote sensing (1)
- Removable (1)
- Renin-angiotensin system (1)
- Reproductive health (1)
- Research collaboration (1)
- Research platform (1)
- Reservoir modelling (1)
- Residual antimicrobial effect (1)
- Residual risk (1)
- Residues (1)
- Resonance frequency analysis (1)
- Restoration (1)
- Resuscitation (1)
- Retinal vein occlusion (1)
- Review (1)
- Rh(D)-blocked phenomenon (1)
- Rhinolophus (1)
- Rhizome growth (1)
- Ribozyme (1)
- Richard Long (1)
- Rifaximin (1)
- Right-wing extremism (1)
- Right-wing group (1)
- Risk assessment (1)
- Risk factors for stroke (1)
- Risk–benefit-assessment (1)
- Robot assisted laparoscopy (1)
- Robotics (1)
- Rodentia (1)
- Roman Climate Anomaly (RCA) (1)
- Root caries (1)
- Rose Bengal staining (1)
- Rosmersholm (1)
- Roux-en-Y gastric bypass (1)
- RpoN signaling (1)
- RuMP pathway (1)
- Rural (1)
- Rwanda (1)
- Ryck (1)
- Rydberg excitons (1)
- Rügen (1)
- S-thioallylation (1)
- S1P receptor signaling (1)
- S1P receptors (1)
- SAM analogue (1)
- SARS-CoV-2 infections (1)
- SARS-CoV-2 rapid antigen test (1)
- SAR‐OSL dating (1)
- SASP (1)
- SAXS (1)
- SBI-G (1)
- SCID (1)
- SCL (1)
- SDMT (1)
- SDS-SP3 protocol (1)
- SEA (1)
- SEM-EDX (1)
- SERS (1)
- SGLT1 (1)
- SH045 (1)
- SHIP (1)
- SHP2 gain-of-function mutation (1)
- SIFamide (1)
- SILAC (1)
- SIRS (1)
- SK-MEL-28 (1)
- SKH1 mouse model (1)
- SLA 3D-printing (1)
- SLC family (1)
- SLC10A1 (1)
- SLC22A1 (OCT1) (1)
- SLC22A2 (1)
- SLC22A9 (1)
- SMAD (1)
- SNP-specific alpha-level (1)
- SNPs (1)
- SNVs (1)
- SNiP (1)
- SNiP study (1)
- SOCIAL MEDICINE (1)
- SP3 (1)
- SPEI (1)
- SPSB1 (1)
- SPecies IDentity and Evolution in R (1)
- SR101 (1)
- SRF (1)
- SRM (1)
- ST1159 (1)
- ST2 (1)
- ST420 (1)
- STEC (1)
- STED microscopy (1)
- STEM performance (1)
- STS (1)
- SUMO (1)
- SW 1353 (1)
- SW Baltic Sea (1)
- SaOs‐2 cell differentiation (1)
- Sacred swamps (1)
- Sal forests (1)
- Salafi jihadism (1)
- Santa Cruz (1)
- Sarcoma (1)
- Sarcopenic adiposity (1)
- Scandinavian Ice Sheet (1)
- Scanning electron microscopy (1)
- Scattering function (1)
- Schamethik (1)
- Schlei (1)
- Schul-Burnout (1)
- Science (1)
- Screening, adolescents (1)
- Sec-translocon (1)
- Sedentary behaviour patterns (1)
- Sedentary breaks (1)
- Sedentary time (1)
- Seeking mental health care model (1)
- Sekundarschülerinnen und Schüler (1)
- Selective caries removal (1)
- Selective neck dissection (1)
- Self-employment (1)
- Self-rated health (1)
- Semantics (1)
- Seniors (1)
- Sensitivity (1)
- Sensorimotor (1)
- Sensorimotor recovery (1)
- Sentinel 2 (1)
- Sequence-function relationships (1)
- Sequenzlernen (1)
- Ser/Thr kinases (1)
- Serotonin (1)
- Sex education (1)
- Sexting (1)
- Sexual health (1)
- Shape dynamics (1)
- Shiga toxin-producing <i>Escherichia coli</i> (1)
- Shiny (1)
- Shiny application (1)
- Short-Form 12 (1)
- Shotgun proteomics (1)
- Shoulders (1)
- SiMoA (1)
- SiSo (1)
- SigB (1)
- Sigmund Freud (1)
- Signal-to-noise ratio (1)
- Silver ions (1)
- Silver sulfadiazine (1)
- Silver wound dressing (1)
- Simulation (1)
- Sin3 (1)
- Single nucleotide polymorphisms (1)
- Skeletal joints (1)
- Slavonic apocrypha (1)
- Slc35f1 (1)
- Sleep (1)
- Sleep apnea (1)
- Sling decompression technique (1)
- Slow wave sleep (1)
- Small dense LDL (1)
- Small for gestational age (1)
- Small-states (1)
- Smartphone app (1)
- Smartphone apps (1)
- Smoking (1)
- Smoking cessation (1)
- Smoking in pregnancy (1)
- Social behavior (1)
- Social brain (1)
- Social identity (1)
- Social inequalities (1)
- Social inequality (1)
- Social law (1)
- Social media (1)
- Social participation (1)
- Socio-economic status (1)
- Sodium hypochlorite (1)
- Soft tissue sarcoma (1)
- Soft tissues (1)
- Soluble APRIL (1)
- Soluble BAFF (1)
- Somatostatin (1)
- Somatostatin receptor (1)
- Sonic Hedgehog signaling (1)
- Sonography (1)
- South Africa (1)
- South West India (1)
- Soviet Socialist Republics (1)
- SoxB (1)
- Soy (1)
- Spaced seeds (1)
- Specialized outpatient palliative care (SOPC) (1)
- Specificity (1)
- Spectral imaging (1)
- Spectral unmixing (1)
- Spectroelectrochemistry (1)
- Spectroscopy (1)
- Speech audiometry (1)
- Sperm conjugation (1)
- Sperm evolution (1)
- Sperm transfer form (1)
- Spermidine (1)
- Sphagnum farming (1)
- Sphagnum magellanicum (1)
- Sphingosin-1-phosphate (1)
- Spiders (1)
- Spintronic devices (1)
- Spirodela polyrhiza (1)
- SplB (1)
- SplD (1)
- Src homology region 2 domain-containing protein-tyrosine phosphatase 2 (SHP2) (1)
- St. John’s wort (1)
- Standardisation (1)
- Staphyloccus aureus (1)
- Staphylococcus (1)
- Stem cell transplantation (1)
- Stencil code (1)
- Stereoselectivity (1)
- Stereotactic surgery (1)
- Stereotyping (1)
- Sterna hirundo (1)
- Stickland reactions (1)
- Stigma (1)
- Stockholm Convention (1)
- Stratum corneum (1)
- Streptococcus pneumoniae 1 (1)
- Stroke (1)
- Structural analysis (1)
- Study of Health in Pomerania (1)
- Study of Health in Pomerania (SHIP) (1)
- Study protocol (1)
- Substance misuse (1)
- Substitution (1)
- Suction blister (1)
- Suction blister technique (1)
- Sunitinib (1)
- SuperPred (1)
- Supracerebellar-infratentorial approach (1)
- Surface barrier discharge plasma source (1)
- Surface treatment (1)
- Surgical procedures (1)
- Surgical strategy (1)
- Surgical trauma (1)
- Survey (1)
- Survey of Neonates in Pomerania (1)
- Survival rate (1)
- Sustainability (1)
- Sustainable Governance Indicators (SGI) (1)
- Sustainable food systems (1)
- Sustainable production and consumption (1)
- Swallowing (1)
- SwissTargetPrediction (1)
- Switzerland (1)
- Synspermiata (1)
- Synthetic design (1)
- Synthetic methods (1)
- Synthetic sandstone (1)
- System dynamics (1)
- Systemic infection (1)
- T cell (1)
- T cell function (1)
- T cell maturation (1)
- T cell receptor beta locus (1)
- T cell superallergen (1)
- T lymphocyte (1)
- T-ALL (1)
- T-cell activation (1)
- T-cells (1)
- TAC (1)
- TAL1 (1)
- TAMs (1)
- TCF11/Nrf1 (1)
- TCL (1)
- TEER (1)
- TEM (1)
- TFE3 (1)
- TFIIA (1)
- TGF-β1 (1)
- TGFβ receptor II (1)
- TGR(mREN2)27 (1)
- THP-1 cells (1)
- THP-1 macrophages (1)
- TIGER2h (1)
- TIGER2hs (1)
- TIGIT (1)
- TIM-3 (1)
- TKI (1)
- TLR4 (1)
- TLR4 signaling (1)
- TME (1)
- TMS (1)
- TNF (1)
- TNF-alpha (1)
- TNF-α (1)
- TNFα (1)
- TREC (1)
- TREM-1 (1)
- TREML2 (1)
- TRPC6 (1)
- TRUCK (1)
- TSH (1)
- TSPAN5 (1)
- TSST-1 (1)
- TUNEL assay (1)
- Tandem-Hirudin (1)
- Targeted therapies (1)
- Tasks (1)
- Tau (1)
- Taurocholate (1)
- Taurolidine (1)
- Tea (1)
- Teeth (1)
- Telehealth (1)
- Telemedical treatment (1)
- Telephone CPR (1)
- Telephone-based therapy (1)
- Telepsychiatry (1)
- Temperature (1)
- Tenericutes (1)
- Terahertz radiation (1)
- Terahertz spectroscopy (1)
- Terai (1)
- TetR‐family repressor (1)
- Tetrasomy 9p (1)
- Tg4-42 (1)
- Th1 (1)
- Th17 (1)
- Th2 (1)
- Th2 cells (1)
- The Baltics (1)
- The Study of Health in Pomerania (1)
- Theodoxus (1)
- Theologie (1)
- Thermodynamics (1)
- Thermostability (1)
- Thiamine Pharmacokinetics (1)
- Thin-skinned thrust tectonics (1)
- Thioredoxin (1)
- Thrombocytopenia (1)
- Thyreophora (1)
- Thyroglobulin (1)
- Thyroid function (1)
- Thyroid hormone (1)
- Thyroid imaging (1)
- Thyrotropin (1)
- Ti-Cu-N coating (1)
- Ti6Al4V alloy (1)
- TiO2 (1)
- Tibial tuberosity osteotomy (1)
- Time course of recovery (1)
- Time trend study (1)
- Time use (1)
- Titanium surface (1)
- Toa1 (1)
- Toarcian (1)
- Toarciconiopteryginae (1)
- Tobacco smoke (1)
- Tolerability (1)
- Tolerance (1)
- Tooth erosion (1)
- Tooth loss (1)
- Tooth wear (1)
- Toothbrushing (1)
- Total testosterone (1)
- Toxicity (1)
- Toxins (1)
- Toxoplasma (1)
- Trabectedin (1)
- Tracheal surgery (1)
- Tracking (1)
- Trajectories (1)
- Transaminase (1)
- Transaminases (1)
- Transepidermal water loss (1)
- Transfusion (1)
- Transfusion reaction (1)
- Transmission electron microscopy (1)
- Transplantation-associated infections (1)
- Transplantrelated morbidity (1)
- Trauma (1)
- Trauma surgery (1)
- Traumatic injury (1)
- Treatment (1)
- Treatment experiences (1)
- Treatment guidelines (1)
- Treatment of food (1)
- Treatment utilization (1)
- Trends (1)
- Trigeminal neuralgia (1)
- Trigonelline (1)
- Triple refractory (1)
- Tris inhibition (1)
- True Cost Accounting (TCA) (1)
- Trust (1)
- Tumor-like behavior (1)
- Tup1 (1)
- Turkish migrants (1)
- Tutorial (1)
- Twitter (1)
- Type-2 diabetes (1)
- Typha (1)
- Tyrosine hydroxylase (1)
- T‐type calcium channels (1)
- UAS (1)
- UPD 11p (1)
- UPR (1)
- UPS (1)
- US alliances (1)
- US security guarantees (1)
- USP apparatus 4 (1)
- USP apparatus 7 (1)
- UUO (1)
- UVA-LED (1)
- UVA-responsive (1)
- Ultrasound (1)
- Ulvan (1)
- Undergraduate curriculum (1)
- Union for International Cancer Control stage (UICC stage) (1)
- Universal Health coverage (1)
- Upland soil cluster (1)
- Urate oxidase (1)
- Urethanase (1)
- Uric acid (1)
- Urinary iodine excretion (1)
- Urine metabolome (1)
- Urological complications (1)
- Ursodeoxycholsäure (1)
- V-loop (1)
- VEGF inhibitors (1)
- VIM (1)
- VITT (1)
- VLDL (1)
- VPA (1)
- VR-12 (1)
- VS-model (1)
- VUV radiation (1)
- Valeric acid (1)
- Validation (1)
- Varenicline (1)
- Variability (1)
- Vascular compression syndromes (1)
- Vascular malformation (1)
- Vector flies (1)
- Venous compression (1)
- Ventral nerve cord (1)
- Verbal memory (1)
- Veresterung (1)
- Vero E6 (1)
- Vertebral artery dissection (1)
- Vestibular system (1)
- Vibrational spectroscopy (1)
- Vietnam (1)
- Violence (1)
- Visceral adipose tissue (1)
- Visceral body fat (1)
- Viscoelastic properties (1)
- Visioning workshops (1)
- Visual system (1)
- Visualization (1)
- Vitamin B6 deficiency (1)
- Vitronectin (1)
- VoC (1)
- Voice examination (1)
- Voluntary wheel running (1)
- Voronoi tessellation (1)
- Voxel-based meta-analysis (1)
- W7-X (1)
- WFD (1)
- WHO (1)
- WHOQOL-BREF (1)
- WHOQOL-OLD (1)
- WON (1)
- WSS (1)
- Walking (1)
- Wallflower effect (1)
- Water jet (1)
- Water-filtered infrared-A radiation (1)
- Weaning (1)
- Weibull (1)
- Wendelstein 7-X (1)
- West Nile virus (1)
- Western blot (1)
- Western diet (1)
- Whole blood (1)
- Whole‐body vibration (1)
- Wismar Bay (1)
- Wnt-signaling (1)
- Worker safety (1)
- Wound (1)
- Wound antisepsis (1)
- Wound at risk of infection (1)
- Wound at risk score (W.A.R. score) (1)
- Wound colonization (1)
- Wound healing (1)
- Wound management (1)
- Wound secretion (1)
- Wounds-at-Risk Score (1)
- X-ray diffraction (1)
- X-ray photoelectron spectroscopy (1)
- X-ray structure (1)
- X-ray tomography (1)
- X-splits (1)
- XRF (1)
- XRF scanning (1)
- X‐ray crystallography (1)
- Yeast sulfhydryl oxidase (1)
- YidC (1)
- Young (1)
- Young stroke (1)
- Z-score standardization (1)
- ZEB1 (1)
- Zi-Pi plot (1)
- Zinc (1)
- Zingst (1)
- Zobellia galactanivorans (1)
- [ (1)
- aPF4/H antibodies (1)
- abdominal swelling (1)
- abductor mechanism deficiency (1)
- abductor repair (1)
- ability to cope (1)
- ablation zone (1)
- abomasum (1)
- aboveground herbivory (1)
- absolute (1)
- absolute protein quantification (1)
- abuse (1)
- academic achievement (1)
- acclimation (1)
- acclimatization (1)
- accumulation (1)
- acetabular retroversion (1)
- acetaminophen (1)
- acetylcholinesterase inhibitors (1)
- acetylene hydratase (1)
- achaete–scute homolog (1)
- achievement (1)
- achievement drive (1)
- acid resistance (1)
- acid suppressive therapy (1)
- acoustic survey (1)
- acquired demyelination syndrome (1)
- acromioclavicular joint dislocation (1)
- actin cytoskeleton (1)
- actin quantification (1)
- active middle ear implant (1)
- acute disseminated encephalomyelitis (1)
- acute kidney injury (1)
- acute myeloid leukemia (1)
- acute toxicity (1)
- acylation (1)
- adaptive immunity (1)
- adaptive immunology (1)
- adaptor protein (1)
- adenine nucleotide translocase 1 (1)
- adherence (1)
- adherent human carcinoma cell lines (1)
- adhesin A (1)
- adhesion inhibitor (1)
- adipose-derived stem cells (1)
- adjuvant (1)
- adjuvants (1)
- administrative claims (1)
- adoptive transfer (1)
- adult attachment representation (1)
- adult-onset (1)
- adulthood (1)
- advanced cell culture (1)
- advanced gastroesophageal cancer (1)
- advanced nursing practice (1)
- advanced nursing roles (1)
- advanced training (1)
- affect heuristic (1)
- affective disorders (1)
- affective neuroscience (1)
- agar (1)
- age differences (1)
- aged (1)
- agency (1)
- aggregate biofilm (1)
- agriculture (1)
- agroecosystems (1)
- airport cases (1)
- airport development (1)
- airway inflammation (1)
- airways (1)
- alamandine (1)
- albuminuria (1)
- alcohol consumption (1)
- alcohol dependence severity (1)
- alcohol risk drinking (1)
- aldehyde production (1)
- alder carr (1)
- alexithymia (1)
- alien invasive species (1)
- alignment of duct-and-mucosa (1)
- aliphatic ketones (1)
- alkenes (1)
- alkyl iodide (1)
- alkylation (1)
- allatostatin (1)
- allelic expression imbalance (AEI) (1)
- allergic reactions (1)
- alliance (1)
- allografts (1)
- aloneness (1)
- alpha diversity (1)
- alpha- beta CD8+ T cells (1)
- alpha-dioxygenase (1)
- alpine (1)
- alumina (1)
- amides (1)
- amiloride-sensitive sodium channel ENaC (1)
- amination (1)
- amine transaminases (1)
- amino acids (1)
- amino alcohols (1)
- amino polymer (1)
- aminoglycoside antibiotics (1)
- amitriptyline (1)
- amorphous formulations (1)
- amorphous solid dispersion (1)
- amplified fragment length polymorphism (AFLP) (1)
- amygdala (1)
- amylase (1)
- amyloid (1)
- amyloid beta (1)
- anaerobic metabolism (1)
- analytic hierarchy process (1)
- analytical measurements (1)
- anastomosis (1)
- anemia (1)
- anesthesiology (1)
- aneurysmal fibrous histiocytoma (1)
- angiogenesis (1)
- angiomatoid fibrous histiocytoma (1)
- angiosarcoma (1)
- angiotensin (1)
- angiotensin 1-7 (1)
- angiotensin II type 1a receptor (1)
- animal (1)
- animal behavior (1)
- animal models (1)
- animal welfare (1)
- annotation (1)
- annually laminated lake sediments (1)
- antenatal care (1)
- anterior medial cingulate cortex (1)
- anthropometry (1)
- anti- (1)
- anti-GD2 antibody (1)
- anti-GD<sub>2</sub> immunotherapy (1)
- anti-VEGF (1)
- anti-adhesive surface (1)
- anti-cancer (1)
- anti-drug antibodies (1)
- anti-inflammatory strategies (1)
- anti-phagocytic activity (1)
- anti-predator (1)
- anti-steatotic action (1)
- anti-tumour immune response (1)
- antiallodynic activity (1)
- antibacterial drug resistance (1)
- antibiotic coating (1)
- antibiotic susceptibility 4 (1)
- antibiotic use (1)
- antibody production (1)
- antibody repertoire (1)
- antibody response (1)
- antibody-dependent cellular cytotoxicity (1)
- antibody-secreting cells (1)
- anticonvulsant (1)
- antiepileptic drug (AED) (1)
- antigen presentation (1)
- antimatter plasma (1)
- antimicrobial coating (1)
- antimicrobial peptide (1)
- antimicrobial plant substances (1)
- antimicrobial resistance crisis (1)
- antimicrobial surface (1)
- antimicrobial susceptibility testing (1)
- antimicrobial therapy (1)
- antioxidant (1)
- antioxidant activity (1)
- antioxidant signaling pathways (1)
- antiseizure medication (1)
- antisense RNA (1)
- antiseptics (1)
- anti‐PF4/heparin antibodies (1)
- anxiety (1)
- aortic arch (1)
- aperiodic tile (1)
- aphasia (1)
- aphids (1)
- apnea-hypopnea index (1)
- apnea–hypopnea index (1)
- apolipoprotein E (1)
- apoptosis-associated speck-like protein (ASC) (1)
- apparently healthy (1)
- approach (1)
- apps (1)
- aptazymes (1)
- aquaculture (1)
- aquaporins (1)
- aquatic snail (1)
- arable farming (1)
- arable wild plants (1)
- araneae (1)
- arbovirus (1)
- archaea (1)
- archetype analysis (1)
- arctic (1)
- area deprivation (1)
- arginine biosynthesis (1)
- arginine phosphorylation (1)
- arid river basins (1)
- arithmetic (1)
- arm ability training (1)
- aroma compounds (1)
- aromatic acids (1)
- artefacts (1)
- arterial smooth muscle (1)
- arterial stiffness (1)
- arterio-venous (1)
- arthroplasty (1)
- arthroscopic shaver (1)
- artificial blood contamination (1)
- artificial blood contamination; (1)
- asphyxia (1)
- aspiration (1)
- assessment/diagnosis (1)
- asymmetric catalysis (1)
- asymptotic expansion (1)
- atmosphere (1)
- atmospheric pressure (1)
- atmospheric pressure argon plasma jet (1)
- atmospheric pressure plasma (1)
- atomic absorption spectrometry (1)
- atomic level scheme (1)
- atomic masses of cesium isotopes (1)
- attentive immobility (freezing) (1)
- attitude measurement (1)
- attitudes (1)
- attitudes and beliefs (1)
- attributes (1)
- audiovisual integration (1)
- auditory brainstem response (1)
- auricular acupuncture (1)
- aurintricarboxylic acid (1)
- authoritarianism (1)
- autoantibodies (1)
- autoimmune diseases (1)
- autoimmune encephalitis (1)
- autoligation (1)
- autologous lipotransfer (1)
- automatic counts (1)
- autonomy (1)
- autophagy-lysosomal pathway (1)
- autoproteolysis (1)
- autoregressive conditional heteroskedasticity (1)
- autosomal-dominant polycystic kidney disease (1)
- autumn (1)
- averaging (1)
- awareness (1)
- azo dyes (1)
- bacillithiol (1)
- background radiation (1)
- bacteremia (1)
- bacterial cell disruption (1)
- bacterial community (1)
- bacterial culture (1)
- bacterial dissemination (1)
- bacterial infection (1)
- bacterial membrane vesicles (1)
- bacterial meningitis (1)
- bacterial-fungal interaction (1)
- bactericidal activity (1)
- bacteriophage (1)
- bacterivory (1)
- balloon pulmonary angioplasty (1)
- barrier analysis (1)
- basal area increment (1)
- baseline imbalance (1)
- bat conservation (1)
- batteries (1)
- battery research (1)
- beach ridge (1)
- beach ridge stratigraphy (1)
- behavior (1)
- behavioral characteristics (1)
- behaviour intention (1)
- behavioural plasticity (1)
- belonging (1)
- benzoate metabolism (1)
- benzothiazoles (1)
- benzoxazoles (1)
- best subset selection (1)
- beta coefficient (1)
- biased ligands (1)
- big data (1)
- big data analysis (1)
- big-fish-little-pond-effect (1)
- bilingual advantage (1)
- bilirubin (1)
- binational medicine (1)
- binding force (1)
- binding land-use plan (1)
- bio-orthogonal click chemistry (1)
- bioassay-guided fractionation (1)
- biobank education (1)
- biobank technician (1)
- biochemical-clinical traits (1)
- biocompatibility (1)
- biocontrol (1)
- biodegradable plastics (1)
- biodegradation (1)
- biodiversity offsets (1)
- bioeconomy (1)
- bioenergetics (1)
- biofilm degradation (1)
- biofilm inhibitor (1)
- biogeochemistry (1)
- bioinformatic (1)
- biological aging (1)
- biological invasion (1)
- biological invasions (1)
- biological soil crusts (1)
- bioluminescence (1)
- biomanipulation (1)
- biomass (1)
- biomass productivity (1)
- biomass valorization (1)
- biomaterial (1)
- biomechanics (1)
- biomedical (1)
- biomedical model swine (1)
- biopharmaceutics (1)
- biosecurity (1)
- biosensor (1)
- biostatistics (1)
- biosynthesis gene cluster (BGC) (1)
- biotechnology (1)
- biotic stress (1)
- bipolar disorder (1)
- bipolar pulse (1)
- birds (1)
- bistriazolylidene ligands (1)
- bivalve (1)
- black-headed gulls (1)
- bleeding tendency (1)
- blink reflex (1)
- blood cell metabolism (1)
- blood compatibility (1)
- blood count (1)
- blood culture (1)
- blood donation (1)
- blood pressure (1)
- blood purification (1)
- blood smear (1)
- blood-brain barrier (1)
- blue intensity (1)
- bodden (1)
- body composition (1)
- body posture (1)
- body size (1)
- body weights and measures (1)
- bog (1)
- bone (1)
- bone cancer (1)
- bone erosion (1)
- bone marrow microenvironment (1)
- bone quality (1)
- bone regeneration (1)
- bone remodelling (1)
- bone turnover marker (1)
- bone-on-a-chip (1)
- boronic acids (1)
- borosilicate (1)
- bovine (1)
- bovine ruminal acidosis (1)
- bovine soft palate (1)
- brackish water system (1)
- brain atrophy (1)
- brain lesion mapping (1)
- brain mapping (1)
- brain plasticity (1)
- brain signal complexity (BSC) (1)
- brain stimulation (1)
- brainstem (1)
- breakdown mechanism (1)
- breakthrough (1)
- breastfeeding (1)
- breastfeeding difficulties (1)
- broad-sense heritability (1)
- broadleaves (1)
- brolucizumab (1)
- brownfields (1)
- bud burst (1)
- bullying (1)
- burden (1)
- burnout (1)
- business travel (1)
- butylscopolamine (1)
- c-Myc (1)
- c-myc (1)
- calanoid copepods (1)
- calcium influx (1)
- calcium ion signaling (1)
- calcium sparks (1)
- calcium-rich hardwater lakes (1)
- calibration (1)
- calorie restriction (1)
- calprotectin (1)
- cambial phenology (1)
- camera trap (1)
- cancellous bone (1)
- cancer cells (1)
- cancer immunity (1)
- cancer risk (1)
- cancer stem cell (1)
- cancer stem cells (1)
- candidemia (1)
- capsule (1)
- capsule-in-capsule (1)
- carbapenamase (1)
- carbapenem (1)
- carbene (1)
- carbene ligands (1)
- carbocations (1)
- carbodicarbene (1)
- carbohydrate metabolism (1)
- carbon allocation (1)
- carbon balance (1)
- carbon catabolite repression (1)
- carbon contamination (1)
- carbon dioxide (1)
- carbon dioxide–based separation (1)
- carbon loss (1)
- carbon storage (1)
- carbon–carbon lyase (1)
- carboplatin (1)
- carboxyesterase (1)
- cardiac (1)
- cardiac H9c2 cells (1)
- cardiac failure (1)
- cardiac fibroblast (1)
- cardiac index (1)
- cardiac remodelling (1)
- cardiac surgery (1)
- cardiolipin composition (1)
- cardiometabolic diseases (1)
- cardiomyocyte (1)
- cardiomyogenic differentiation (1)
- cardioprotection (1)
- cardiopulmonary disease (1)
- cardiorespiratory exercise capacity (1)
- cardiotoxicity (1)
- cardiovascular diseas (1)
- cardiovascular implants (1)
- care (1)
- care management (1)
- career trajectories (1)
- caregiver (1)
- caregiving (1)
- cargo ships (1)
- caries prevention (1)
- carnitine (1)
- carotid endarterectomy (1)
- carrageenan (1)
- cartilage (1)
- cascade reaction (1)
- case duration (1)
- case illustration (1)
- case-control study (1)
- casein kinase II (1)
- caspase-3/7 assay (1)
- catalyses (1)
- catalytic activity (1)
- catalytic triad (1)
- catchment (1)
- cathepsins (1)
- cathodes (1)
- cattle (1)
- causality (1)
- causation (1)
- cell adhesion (1)
- cell biology (1)
- cell cycle arrest (1)
- cell cycle regulator (1)
- cell elasticity (1)
- cell fractionation (1)
- cell membrane (1)
- cell membrane stabilizer (1)
- cell physiology (1)
- cell proliferation regulating inhibitor of protein phosphatase 2A (1)
- cell spreading (1)
- cell surface antigens (1)
- cell wall metabolism (1)
- cell-material interaction (1)
- cellobiose (1)
- cells (1)
- cellular regulation (1)
- cellular sensitivity (1)
- cellulose degradation (1)
- cell‐surface contacts (1)
- central hemodynamics (1)
- central nervous system (1)
- central pattern generation (1)
- central sensitization (1)
- cerebral (1)
- cerebral hemorrhage (1)
- cerebral palsy (1)
- cerebral thrombosis (1)
- cerebral toxoplasmosis (1)
- cerebrospinal fluid (CSF) (1)
- cerebrospinal fluid; (1)
- certified prostate cancer centers (1)
- cesarean section (1)
- ch14.18/CHO (1)
- character strengths (1)
- characterization of patients (1)
- charcoal (1)
- checkerboard (1)
- chemerin (1)
- chemo-sensitivity (1)
- chemoenzymatic cascade (1)
- chemokine receptors (1)
- chemoluminescence immunoassay (1)
- chemosynthesis (1)
- child (1)
- childhood (1)
- chiral amines (1)
- chiral metabolism (1)
- chiral resolution (1)
- chiral stationary phase (1)
- chiroptera (1)
- chitin-binding domain (1)
- chondrocyte isolation (1)
- chondrosarcoma (1)
- chromatin (1)
- chromatin remodeling (1)
- chromoplexy (1)
- chromosomal translocations (1)
- chromosomally inserted plasmid (1)
- chromosome conformation capture (1)
- chronic (1)
- chronic (health) condition (1)
- chronic condition (1)
- chronic depression (1)
- chronic inflammation (1)
- chronic kidney disease (CKD) (1)
- chronic periodontitis (1)
- chronic post-stroke aphasia (1)
- chronic stroke (1)
- chronic thromboembolic pulmonary disease (1)
- chronic wound (1)
- chronic wounds (1)
- chronotypes (1)
- circadian clock (1)
- circadian rhythm (1)
- cirrhosis (1)
- cis-muconic acid (1)
- citrulline (1)
- claims data (1)
- classification models (1)
- classification system (1)
- classroom characteristics (1)
- clavicle fracture (1)
- clavicular combination injury (1)
- clear cell foci (1)
- clear cell foci of altered hepatocytes (1)
- clear cell renal cell carcinoma (1)
- cleavage (1)
- click chemistry (1)
- climate (1)
- climate awareness (1)
- climate behavior (1)
- climate change mitigation (1)
- climate conditions (1)
- climate elasticity (1)
- climate extreme (1)
- climate fluctuations (1)
- climate justice (1)
- climate protection (1)
- climate regime (1)
- climate sensitivity (1)
- climate variability (1)
- climate-growth relationship (1)
- climatic adaptation (1)
- cline (1)
- clinical attachment level (1)
- clinical chemistry (1)
- clinical classifications (1)
- clinical decision (1)
- clinical decision support (1)
- clinical decision support tool (1)
- clinical decision-making (1)
- clinical drugs (1)
- clinical guideline recommendations (1)
- clinical innovation (1)
- clinical practice (1)
- clinical psychology (1)
- clinical study (1)
- clinical trial (1)
- clinically important restrictions and symptoms (1)
- clonal (1)
- clonal complex (1)
- clonal reproduction (1)
- clonal trees (1)
- cloud removal (1)
- cluster (1)
- cluster formation (1)
- cluster model (1)
- cluster-randomized controlled trial (1)
- co-occurrence (1)
- co-occurrence network (1)
- co-substrate recycling (1)
- co-transcriptional regulation (1)
- coastal aquifer (1)
- coastal dunes (1)
- coastal geomorphology (1)
- coated (1)
- codon (1)
- coffee metabolites (1)
- cognition(s) (1)
- cognitive intervention (1)
- cognitive neuroscience (1)
- cognitive reappraisal (1)
- cognitively normal (1)
- cohorts (1)
- cold argon plasma (1)
- cold atmospheric pressure plasma (CAP) (1)
- cold edge (1)
- cold events (1)
- cold physical plasmas (1)
- cold plasma (1)
- cold shock proteins (1)
- cold tolerance (1)
- collaborative care (1)
- collagen-induced arthritis (1)
- collective action (1)
- colocalization (1)
- colon (1)
- colonic atresia (1)
- colonization type (1)
- colony biofilm (1)
- colony counting (1)
- color space differences (1)
- combination assay (1)
- combination with antibiotic (1)
- commensal (1)
- common cause hypothesis (1)
- common garden experiment (1)
- communication skills (1)
- communication studies (1)
- community detection (1)
- community settings (1)
- community-based participatory research (1)
- commuting (1)
- compensation account (1)
- compensatory growth (1)
- competence (1)
- competition (1)
- complement activation (1)
- complement dependent cytotoxicity (1)
- complement-dependent cytotoxicity (1)
- complete blood count (1)
- complex lipids (1)
- complex plasma (1)
- complex plasmas (1)
- complex problem solving (CPS) (1)
- complex regional pain syndrome (1)
- compliance (1)
- complications (1)
- composite ridges (1)
- composition (1)
- compound (1)
- compression injury (1)
- compression-coated tablet (1)
- computational modeling (1)
- computational simulation (1)
- computer invention (1)
- computer-based testing (1)
- computer-interpretable guideline (1)
- concentration coefficient (1)
- concussion (1)
- conditional association analysis (1)
- conduit reinforcement (1)
- conflict (1)
- conformational changes (1)
- congenital (1)
- congenital abnormality (1)
- congenital heart disease (1)
- congenital hyperinsulinism (1)
- consciousness (1)
- consensus and efficiency (1)
- consent (1)
- conservation management (1)
- consolidated framework for implementation research (1)
- constant therapy (1)
- construal (1)
- contact killing surface (1)
- contact tracing (1)
- contamination (1)
- continental slope (1)
- continuous manufacturing (1)
- continuous outcome (1)
- contourites (1)
- contribution margin (1)
- control diet (1)
- control measure (1)
- control measures (1)
- convolutional neural networks (1)
- copepod eggs (1)
- coping skills (1)
- copper nitride (1)
- copper(II) complexes (1)
- copulatory mechanics (1)
- copy number variants (1)
- cormorants (1)
- coronary heart disease (1)
- corpus callosum (1)
- correlation analysis (1)
- correlation studies (1)
- corridor development strategies (1)
- corrosion (1)
- cortical thickness (1)
- corticospinal excitability (1)
- cost analysis (1)
- cost of illness (1)
- costal arch fracture (1)
- costing (1)
- coumarins (1)
- counseling (1)
- counterfactual analysis (1)
- counterfactual scenarios (1)
- counter‐gradient variation (1)
- coupled phonon-plasmon modes (1)
- coupling efficiency (1)
- cranial (1)
- creative thinking (1)
- creative/fluent verbal association (1)
- creativity (1)
- crenolanib (1)
- crisis (1)
- crisis communication (1)
- criterial (1)
- crop production (1)
- cross border education (1)
- cross-border multiprofessional team (1)
- cross-cultural psychology (1)
- cross-lagged panel design (1)
- cross-sectional study (1)
- cross‐stress tolerance (1)
- crp (1)
- cruise ships (1)
- crustaceans (1)
- cryofixation (1)
- cryptic species (1)
- cryptochrome (1)
- crystallized intelligence (1)
- cutaneous T-cell lymphoma (1)
- cuttlefish (1)
- cyanobacterial protease inhibitors (1)
- cyanotoxin (1)
- cyberbullying (1)
- cyclic voltammetry (1)
- cyclin dependent kinase (1)
- cyclin-dependent kinase inhibitor (1)
- cyclooxygenase-2 (1)
- cylindrospermopsin (1)
- cytochrome P450 (1)
- cytokine (1)
- cytokine adsorption (1)
- cytokinesis (1)
- cytoplasmic membrane (1)
- cytoskeleton (1)
- da Vinci (1)
- daidzein (1)
- dairy cows (1)
- dalbavancin (1)
- damage-associated molecular patterns (1)
- dancers (1)
- data (1)
- data integration (1)
- data mining (1)
- data quality (1)
- data quality monitoring (1)
- data reporting (1)
- data sciences (1)
- data-mining (1)
- dating (1)
- decision making of governments (1)
- decision regret (1)
- deep pluralism (1)
- deep sequencing (1)
- deep tracheal aspirate (1)
- deep‐marine deposits (1)
- deforestation and forest degradation (1)
- degeneracy (1)
- degradation (1)
- dehalogenase (1)
- dehydroepiandrosterone (1)
- deiodinase (1)
- delegation (1)
- deliberative accountability (1)
- delivery mode (1)
- dementia care (1)
- democratic backsliding (1)
- democratic decision making (1)
- democratic theory (1)
- demographic change (1)
- dendritic spine function (1)
- dendrochemistry (1)
- dendroecology (1)
- dendrometer measurements (1)
- dendrophenotype (1)
- dengue virus (1)
- denial (1)
- density limit (1)
- dental (1)
- dental caries (1)
- dental education (1)
- dental flossing (1)
- dental plaque (1)
- dental students (1)
- dentine (1)
- dentition, permanent (1)
- depresion (1)
- derivatives (1)
- dermal full-thickness wounds (1)
- dermatofibroma (1)
- dermatology (1)
- dermatophytosis (1)
- detergents (1)
- determinants (1)
- deterrents (1)
- developing countries (1)
- developmental origins of health and disease (1)
- diabetic foot (1)
- diagnosis-related groups (DRG) (1)
- diagnostic (genetic) characters (1)
- diagnostic and predictive genetic analyses (1)
- diagnostic error (1)
- diagnostic radiologic examination (1)
- diagnostic support (1)
- diagnostic techniques and procedures (1)
- diagnostic tests/Investigation (1)
- diallyl polysulfane (1)
- diarrhoea (1)
- diatom (1)
- diazoxide (1)
- dielectric response (1)
- diet-induced obesity (1)
- dietary change (1)
- differential diagnosis (1)
- difficult pro-environmental behaviors (1)
- diffuse nutrient runoff (1)
- diffusion tension imaging (DTI) (1)
- diffusion tractography (1)
- digital elevation models (1)
- dihedral principal component analysis (1)
- dihydrochalcones (1)
- dilated cardiomyopathy (1)
- direct-on-target microdroplet growth assay (1)
- directed acyclic graphs (1)
- dirty mouse (1)
- disability (1)
- disagreement (1)
- disaster (1)
- disaster management cycle (1)
- disaster nursing (1)
- discharge evolution (1)
- discharge mode transition (1)
- disease behavior (1)
- disease emergence (1)
- disease progression (1)
- disease recognition (1)
- disease severity (1)
- disease vector (1)
- disease-modifying therapy (1)
- displacement peat (1)
- disruption (1)
- dissolution (1)
- dissolution mechanism (1)
- dissolution method (1)
- dissolution methods (1)
- distress (1)
- distribution (1)
- dithiolene (1)
- dithiolene ligand (1)
- diurnal rhythm (1)
- divergent thinking (DT) (1)
- diversification (1)
- diversity (1)
- doliolids (1)
- domain unfolding (1)
- domain-specific language (1)
- donor human milk (1)
- dormancy induction (1)
- dormancy level (1)
- dormancy release (1)
- dot blot (1)
- dragonfly migration (1)
- drivers (1)
- droplet microfluidics (1)
- drought limitation (1)
- droughts (1)
- drug delivery (1)
- drug design (1)
- drug discovery (1)
- drug metabolizing enzymes (1)
- drug screening (1)
- drug trials (1)
- drug-drug interaction (1)
- drug-eluting (1)
- drug-eluting implant (1)
- drug–drug interaction (1)
- dry edge (1)
- dry-cold season (1)
- drying–rewetting (1)
- dual RAS blockade (1)
- dual task (1)
- ductal closure (1)
- ductal epithelium (1)
- duration (1)
- dynamic light scattering (1)
- dynamic simulation (1)
- dynaxity (1)
- dysferlin (1)
- dysplasia (1)
- dystrophin (1)
- eGFR (1)
- eHealth (1)
- eQTL (1)
- ear canal stenosis (1)
- early childhood caries (1)
- early competencies (1)
- early detection of cancer (1)
- early life discrimination (1)
- early onset MS (1)
- early-life adversity (1)
- ease of swallowing (1)
- eating behavior (1)
- eating behaviour (1)
- echocardiography (1)
- ecological momentary assessment (1)
- ecology (1)
- economic burden (1)
- economic development (1)
- ecophysiology (1)
- ecosystem diversity (1)
- ecosystem functioning (1)
- ecosystem modeling (1)
- ecosystem service valuation (1)
- ecosystem services (1)
- ectogenic meromixis (1)
- eddy covariance (1)
- edentulism (1)
- educast (1)
- educational decisions (1)
- educational podcast (1)
- effective public participation (1)
- effectiveness (1)
- effector memory T cells (TEMs) (1)
- efflux (1)
- efflux pump inhibitor (1)
- eigenvector centrality mapping (1)
- electoral law reform (1)
- electric field (1)
- electric fields (1)
- electric propulsion (1)
- electroconvulsive therapy (1)
- electromyography (1)
- electron cyclotron emission (1)
- electron energy loss spectroscopy (1)
- electron microscopy (1)
- electron transfer (1)
- electron-positron plasma (1)
- electronegativity (1)
- electronic health records (1)
- electronic structure (1)
- electron–positron plasma (1)
- elements (1)
- embodied cognition (1)
- emergency alert (1)
- emergency imaging (1)
- emerging diseases (1)
- emotion perception (1)
- emotion processing (1)
- emotional stress (1)
- empathetic concern (1)
- empirical modelling (1)
- enable-cluster (1)
- enamel (1)
- enantiopure ( (1)
- endocarditis (1)
- endodormancy (1)
- endolysin (1)
- endoplasmic reticulum stress (1)
- endoscopic characteristics (1)
- endoscopy (1)
- endosymbiont (1)
- endothelial activation (1)
- endothelial cells (1)
- endothelial cells VEGF (1)
- endothelial-specific gene expression (1)
- endothelin receptor expression (1)
- endothelin system (1)
- energy metabolism (1)
- energy-resolved ion mass spectrometry (1)
- enolase (1)
- enteral nutrition (1)
- enteric hard capsule (1)
- environmental DNA (1)
- environmental DNA (eDNA) (1)
- environmental activism (1)
- environmental change (1)
- environmental epidemiology (1)
- environmental factors (1)
- environmental gradient (1)
- environmental history (1)
- environmental offsets (1)
- environmental parameters (1)
- environmental psychology (1)
- environmental samples (1)
- environmental stress (1)
- environmental surveillance (1)
- enzyme (1)
- enzyme cascade (1)
- enzyme immunoassay (1)
- enzymes (1)
- eolian activity (1)
- eosinophilic esophagitis (1)
- eosinophilic granuloma (1)
- epidemiologic studies (1)
- epidermal differentiation inhibitors (1)
- epidermal growth factor receptor (1)
- epigenome (1)
- epilepsy of unknown origin (1)
- epileptic encephalopathies (1)
- epithelial fluid secretion (1)
- epithelial-to-mesenchymal transition (1)
- erythrocyte (1)
- esophageal diseases (1)
- esophageal transport (1)
- esophagus (1)
- esophagus therapy (1)
- essentail oils (1)
- essential thrombocythemia (ET) (1)
- essentials elements (1)
- esterases (1)
- estimated bone mineral density (1)
- estimated glomerular filtration rate (eGFR) (1)
- estradiol (1)
- estradiol; (1)
- estrogen (1)
- estrogen receptor (1)
- estrone sulfate transporter (1)
- estrone-3-sulfate (1)
- ethics expertise (1)
- ethics of media use (1)
- ethics of shame (1)
- ethidium bromide uptake (1)
- ethnobotany (1)
- evaluation (1)
- evaluation of ecological restoration measures (1)
- evapotranspiration (1)
- event coincidence analysis (1)
- evidence-based medicine (1)
- evidence-based practice (1)
- evoked potentials (1)
- evolution (1)
- evolutionary potential (1)
- ex vivo measurements (1)
- exclusion (1)
- exfoliative toxins (1)
- exhaled breath (1)
- existence regimes (1)
- exopolysaccharides (1)
- expectancy violation (1)
- expectations (1)
- experimental microcosms (1)
- experimental radiology (1)
- experimental stroke (1)
- expert identification (1)
- expert opinion adjudication (1)
- expertise (1)
- exploratory data analysis (1)
- expression quantitative trait loci (eQTL) (1)
- extended-spectrum ß-lactamase-producing (1)
- extension of glacier records (1)
- external auditory canal (1)
- external evidence (1)
- extinction (1)
- extinction risk (1)
- extra-organismal DNA (1)
- extracellular matrix proteins (1)
- extracellular traps (1)
- extracellular vesicle (EV) (1)
- extracellular vesicle isolation (1)
- extracellular vesicles diagnostics (1)
- extracorporeal life support (1)
- extraction (1)
- extractions (1)
- extreme warming events (1)
- eye lens cell membrane (1)
- eye-disease (1)
- eye-tracking (1)
- fNIRS (1)
- fT3 (1)
- fT4 (1)
- face memory (1)
- facial emotional recognition (1)
- facial expression (1)
- fall (1)
- family VIII carboxylesterase (1)
- family structure (1)
- farming (1)
- fasted and fed state conditions (1)
- fat (1)
- fat-free mass (1)
- fatty acid (1)
- fatty acid composition (1)
- fatty aldehydes (1)
- fear (1)
- fear bradycardia (1)
- fear conditioning (1)
- fear of abandonment (1)
- feature selection (1)
- fecal culture (1)
- fecal headspace (1)
- feces (1)
- feedback (1)
- feedstock (1)
- female hormones (1)
- feminist epistemology (1)
- femoroacetabular impingement syndrome (1)
- femoroplasty (1)
- fen rewetting (1)
- fertility decisions (1)
- fetal and adult neurogenesis (1)
- fetal zone steroids; (1)
- fibrinogen (1)
- fibroblast activation protein α (1)
- fibroblasts (1)
- field experiment (1)
- figural matrices (1)
- films (1)
- findable, accessible, interoperable, and reusable data principles (1)
- finger counting (1)
- finger-based training (1)
- finger-tapping task (1)
- fingerprinting (1)
- fish (live) (1)
- fisheries (1)
- fitness traits (1)
- flash freezing (1)
- flesh (1)
- floating clavicle (1)
- floating mat (1)
- flooded grasslands (1)
- florfenicol (1)
- flossing (1)
- flow cytometry (1)
- flow cytometry – methods (1)
- flow dynamics (1)
- flow‐mediated dilation (1)
- fluid (gf) and crystallized intelligence (gc) (1)
- fluid simulation (1)
- fluorescein-guided biopsy (1)
- fluorescein-guided surgery (1)
- fluorescence imaging (1)
- fluorescence-activated cell sorting (1)
- fluorescent pseudomonads (1)
- fluoride (1)
- fluorine (1)
- fluoroscopy (1)
- focused ion beam (1)
- follow-up treatment (1)
- food chain (1)
- food cravings (1)
- food geographies (1)
- food markets (1)
- food production industry (1)
- food quantity (1)
- food safety (1)
- food spoilage (1)
- food spoilers (1)
- foot-and-mouth disease virus (FMDV) (1)
- forecasts (1)
- foredune progradation (1)
- forest ecosystem research (1)
- forest fire (1)
- forest growth-trends (1)
- forest inventory (1)
- forest management regime (1)
- forest monitoring (1)
- forests (1)
- formalin fixed and embedded brain sample (1)
- former nurses (1)
- formulation design (1)
- formylglycine-generating enzyme (1)
- fractals (1)
- free light chains kappa (1)
- free radicals (1)
- free will (1)
- freedom (1)
- frontal alpha activity (1)
- frontal beta activity (1)
- fronto-temporal cortex (1)
- functional connectivity (1)
- functional models (1)
- functional outcome (1)
- functional recovery (1)
- functional traits (1)
- funding priorities (1)
- fungal growth inhibition (1)
- fungi (1)
- fusarium (1)
- fusidic acid (1)
- fusion plasma (1)
- gag reflex (1)
- gamma (1)
- ganglioside GD2 (1)
- gap analysis (1)
- gas cell (1)
- gas plasma technology (1)
- gastric emptying (1)
- gastrointestinal cancer (1)
- gastrointestinal lymphoma (1)
- gastrointestinal microbiome (1)
- gemcitabine (1)
- gender inequality (1)
- gene library (1)
- gene repression (1)
- gene structure (1)
- general mental ability (1)
- general population sample (1)
- general population-based cohort (1)
- genetic (1)
- genetic association study (1)
- genetic code expansion (1)
- genetic correlation (1)
- genetic correlation analysis (1)
- genetic councelling (1)
- genetic counseling (1)
- genetic diversity (1)
- genetic predisposition (1)
- genetic risk (1)
- genetic testing (1)
- genetic variants (1)
- genistein (1)
- genitalia (1)
- genome comparison (1)
- genome size (1)
- genome-wide association studies (GWAS) (1)
- genomic epidemiology (1)
- genotype (1)
- genotype–environment interaction (1)
- genotype–phenotype associations (1)
- genotyping‐by‐sequencing (1)
- geochemistry (1)
- geographical variability (1)
- geometric morphometrics (1)
- geophysics (1)
- geriatric medicine (1)
- geriatrics (1)
- germ stem cell (1)
- germinal center reaction (1)
- germination (1)
- gestural-verbal association (1)
- ghost cells (1)
- gilteritinib (1)
- gingival recession (1)
- glacier skiing (1)
- glaciology (1)
- glacitectonics (1)
- glass transition (1)
- glia (1)
- glioblastoma (1)
- glioblastoma multiforme (1)
- global (1)
- global production networks (1)
- global warming (1)
- globalization (1)
- glomerular filtration rate (1)
- glomerulus (1)
- glow-like discharge (1)
- glucocorticoids (1)
- glucose homeostasis (1)
- glucose metabolism (1)
- glucose tolerance (1)
- glucose uptake (1)
- glutaredoxin (1)
- glutathione peroxidase (1)
- glutathione peroxidase-1 (1)
- gluteus maximus flap transfer (1)
- gluteus medius (1)
- glycolysis (1)
- glycoside hydrolase (1)
- glycosidic torsion angles (1)
- go/no-go task (1)
- gold dissolution (1)
- gonad (1)
- goose bumps (1)
- goose-fronting (1)
- governance (1)
- government activity (1)
- governments (1)
- grade level differences (1)
- gradient experiment (1)
- granulocyte subpopulation (1)
- granuloma (1)
- graph analysis (1)
- graphite furnace atomic absorption spectrometry (1)
- graphite furnace technique (1)
- grassland (1)
- grassland ecosystem (1)
- gray matter volume (1)
- grazing (1)
- greenfield FDI (1)
- greenfields (1)
- greenhouse experiment (1)
- greenhouse gas emissions (1)
- grit (1)
- gross tumor volume optimization (1)
- ground spiders (1)
- group B streptococcus (1)
- group therapy (1)
- growing media (1)
- growth dynamics (1)
- growth factors (1)
- growth inhibition (1)
- growth inhibitory effect (1)
- growth rates (1)
- growth response (1)
- growth–climate response (1)
- guided streamer (1)
- guideline (1)
- guideline [MeSH] (1)
- guideline adherence (1)
- gustation (1)
- gut microbiome (1)
- gut microbiota (1)
- gut–lung axis (1)
- hBD3 (1)
- habitat (1)
- habituation (1)
- hair follicles (1)
- hairpin ribozyme (1)
- halide methyltransferase (1)
- halides (1)
- haloalkane (1)
- haloarchaea (1)
- haloperoxidase (1)
- hand function (1)
- handgrip strength (1)
- haplogyne (1)
- haploidentical allogeneic stem cell transplantation (1)
- haplotypes (1)
- harm avoidance (1)
- harsh sounds (1)
- harvesting tools (1)
- hay fever (1)
- hazard type (1)
- head and neck squamous cell carcinoma (1)
- head motion (1)
- headache (1)
- healtcare (1)
- health behaviors (1)
- health care (1)
- health care delivery (1)
- health care quality (1)
- health care satisfaction (1)
- health costs (1)
- health information network (1)
- health risk behaviors (1)
- health risk factors (1)
- health service research (1)
- health services research (1)
- health-related quality of life (HRQL) (1)
- healthcare surveys (1)
- healthcare utilization (1)
- healthy aging (1)
- healthy human oral microbiome (1)
- healthy older adults (1)
- healthy participants (1)
- hearing impairment (1)
- heart failure with preserved ejection fraction (1)
- heart rate variability (HRV) (1)
- heat shock protein 27 (1)
- heat tolerance (1)
- heat-shock proteins (1)
- heavy actinides (1)
- helium barrier discharge (1)
- helium–oxygen barrier discharge (1)
- help-seeking intervention (1)
- helplessness (1)
- hematogenous (1)
- hematogenous implant-related infections (1)
- hematologic dysfunction (1)
- hematologic malignancies (1)
- hematophagous leeches (1)
- hematopoiesis (1)
- hematopoietic stem cell transplantation (1)
- hemoglobin A1c (1)
- hemolysis (1)
- hemostasis (1)
- heparin- and antibody-induced thrombocytopenia (1)
- heparin-induced thrombocytopenia (1)
- heparins (1)
- hepatic pathology (1)
- hepatic steatosis (1)
- hepatitis C (1)
- hepatobiliary cancer (1)
- hepatocarcinogenesis (1)
- herbivory (1)
- hereditary breast and ovarian cancer (1)
- hereditary pancreatitis (1)
- hereditary thrombocytopenias (1)
- heritage languages (1)
- heterogeneous catalysis (1)
- hidden populations (1)
- high fat diet (1)
- high power impulse magnetron sputtering (1)
- high school students (1)
- high temperature (1)
- high temperatures (1)
- high-ability tracked students (1)
- high-frequency heart rate variability (1)
- high-resolution manometry (1)
- high-risk neuroblastoma (1)
- high-throughput screening (1)
- higher education (1)
- high‐risk (1)
- hip (1)
- hip arthroscopy (1)
- hip joint (1)
- hip preservation (1)
- hip region (1)
- hip replacement (1)
- hippocampal subfields (1)
- hippocampal volume (1)
- hippocampus (1)
- hirudin‐like factors (1)
- histamine (1)
- histone variants (1)
- histopathology (1)
- history of fMRI (1)
- hollow cathode discharge (1)
- home nursing (1)
- home office (1)
- homoarginine (1)
- honeybees (1)
- horse (1)
- hospital financing (1)
- host genetic diversity (1)
- host-pathogen interaction (1)
- host-pathogen interactions (1)
- host-pathogen-interaction (1)
- host‐plant preference (1)
- hotmelt extrusion (1)
- hotodecarboxylase (1)
- household income (1)
- human NTCP (1)
- human association studies (1)
- human breast milk (1)
- human cell lines (1)
- human disturbance (1)
- human induced pluripotent stem cell-derived cardiomyocytes (1)
- human intestinal mucosa (1)
- human kidneys (1)
- human milk (1)
- human osteoblast cells (1)
- human osteoblasts (1)
- human population growth (1)
- human resources (1)
- human umbilical vein endothelial cells (1)
- humanized mice (1)
- humans (1)
- human–machine interaction (1)
- humoral immune response (1)
- hyaluronic acid microgels (1)
- hybrid molecules (1)
- hybridization (1)
- hydration (1)
- hydraulic conductivity (1)
- hydraulic stability (1)
- hydraulic traits (1)
- hydrazones (1)
- hydrogen (1)
- hydrogen evolution (1)
- hydrogeochemistry (1)
- hydrological regimes (1)
- hydrolysis (1)
- hydrothermal vents (1)
- hydroxyethyl starch (1)
- hydroxypropyl methyl cellulose (1)
- hydroxypropyl methyl cellulose acetate succinate (1)
- hydroxytyrosol (1)
- hydroxytyrosol acetate (1)
- hypermentalization (1)
- hyperoxia (1)
- hyperspectral image processing (1)
- hyperspectral imaging (1)
- hypertension (1)
- hypnosis (1)
- hypochlorous acid (1)
- hypothyroidism (1)
- hypoxia reoxygenation (1)
- hypoxia reoxygenation injury (1)
- hypoxia-ischemia (1)
- iPSC-derived endothelial cells (1)
- iPSCs (1)
- ibuprofen (1)
- idealism (1)
- identity (1)
- idiographic models (1)
- idiopathic dilated cardiomyopathy (1)
- idiopathic pulmonary fibrosis (1)
- iliopsoas tendon (1)
- illiberalism (1)
- image reconstruction (1)
- imaging (1)
- imaging artifact (1)
- imaging tools (1)
- imidazo[2,1-<i>c</i>][1,2,4]triazol-3(5<i>H</i>)-imines (1)
- imipenem (1)
- immediate and delayed memory (1)
- immobilization (1)
- immobilized (1)
- immune alterations (1)
- immune cells (1)
- immune complex (1)
- immune evasion cluster (1)
- immune polarization (1)
- immune suppression (1)
- immuno-magnetic purification (1)
- immunoadsorption (1)
- immunofluorescence (1)
- immunoglobulin synthesis (1)
- immunoglobulins (1)
- immunomodulation (1)
- immunomonitoring immunotherapy (1)
- immunoproteasome (iP) (1)
- immunosenescence (1)
- impact mitigation regulation (1)
- impairments (1)
- impingement (1)
- implant (1)
- implant coating (1)
- implants (1)
- implementation (1)
- implementation research (1)
- implicit biases (1)
- implied volatility surface (1)
- imprecision (1)
- impulse control (1)
- imputation (1)
- in silico target prediction (1)
- in vitro anticancer activity (1)
- in vitro antitumor activity (1)
- in vitro dissolution (1)
- in vitro drug release (1)
- in vitro infection model (1)
- in vitro model (1)
- in vitro stability (1)
- in vitro testing (1)
- in vitro–ex vivo correlation (1)
- in vivo disintegration (1)
- in vivo study (1)
- in vivo virulence (1)
- inactivation (1)
- inactivity (1)
- inbreeding (1)
- incision time (1)
- income (1)
- incremental validity (1)
- indicator injury (1)
- indirect effect (1)
- individual academic self-concept (SESSKO) (1)
- individual based (1)
- individual differences (1)
- individual fruit weight (1)
- individual participant data (1)
- individualised intervention (1)
- individualized feedback (1)
- individualized medicine (1)
- indoleamine 2,3-dioxygenase (1)
- indomethacin (1)
- induced pluripotent stem cells (1)
- inductively-limited discharge (1)
- industrial catalysis (1)
- infants (1)
- infected wounds (1)
- infectious diseases (1)
- infectious virus (1)
- inflammatory bowel disease (1)
- inflammatory bowel diseases (1)
- inflammatory/immunological response (1)
- influenza A virus infection (1)
- informal care (1)
- information (1)
- information retrieval (1)
- infrared light barrier (1)
- infrastructure (1)
- inherited cardiomyopathy (1)
- inherited platelet defects (1)
- inherited platelet disorders (1)
- inhibition of tumour cell proliferation (1)
- initial data analysis (1)
- innate immune response (1)
- innate immune system (1)
- innate lymphoid cells (1)
- innate response activator B cells (IRA B cells) (1)
- innateness (1)
- inner urban development (1)
- inorganic materials (1)
- ins/del variant (1)
- insect migration (1)
- insect‐plant interaction (1)
- instrumentality of harm (1)
- insufficient milk (1)
- insulin resistance (1)
- insurance claims (1)
- integrated multi-omics (1)
- integrated stress response (1)
- integrative medicine (1)
- integrin signaling (1)
- integrin αIIbβ3 (1)
- intelligence (1)
- intelligent tutoring systems (1)
- intensified treatment (1)
- intensive care unit acquired weakness (1)
- intensive speech-language therapy (1)
- inter-dental cleaning (1)
- interactive effect (1)
- interchange (1)
- intercomprehension (1)
- intercostal hernia (1)
- interdental brushes (1)
- interdental brushing (1)
- interdental cleaning aids (1)
- interdisciplinary (1)
- interdisciplinary health team (1)
- interferon (1)
- interferon-stimulated genes (ISG) (1)
- interferonopathy (1)
- interhemispheric connectivity (1)
- interhemispheric inhibition (1)
- interlayers (1)
- interleukin 2 (1)
- interlingual transfer (1)
- internal evidence (1)
- internalization (1)
- internet interventions (1)
- interpersonal problems (1)
- interpersonal skills (1)
- interprofessional attitude (1)
- interprofessional education (1)
- interregional migration (1)
- interspecific hybrids (1)
- interspecific polymorphism (1)
- interstitial lung disease (1)
- intervention development (1)
- intervention measure (1)
- intervention measures (1)
- interventional EUS (1)
- intestinal application (1)
- intestinal parasite diversity (1)
- intestinal tract microbiome (1)
- intra-class correlation (1)
- intramuscularly implantation (1)
- intraocular inflammation (1)
- intraoperative analgesia (1)
- intraportal pancreatic islet transplantation (1)
- intraseasonal variation (1)
- intraspecific diversity (1)
- intraspecific trait variation (1)
- intraspecific variation (1)
- intravaginal ring (1)
- intravitreal (1)
- intravitreal implants (1)
- introgression (1)
- invasion (1)
- invasive cardiopulmonary exercise testing (1)
- invasive mold infection (1)
- invasive pneumococcal disease (1)
- invasive route (1)
- invasive species (1)
- invertebrate host (1)
- invertebrate-derived DNA (iDNA) (1)
- in situ-ICP-MS (1)
- ion channels (1)
- ion chromatography (1)
- ion composition (1)
- ion insertion (1)
- ionizing radiation (1)
- ionosphere modeling (1)
- ipratropium (1)
- iron (1)
- iron based superconductors (1)
- iron limitation (1)
- iron surrogates (1)
- iron-sulfur cluster (1)
- ischemia reperfusion (1)
- ischemia-induced cell death (1)
- isobutyrylcarnitine (1)
- isoflavonoid (1)
- isoprenoid degradation (1)
- isothermal titration calorimetry (ITC) (1)
- item banking (1)
- job performance (1)
- job satisfaction (1)
- jobe test (1)
- judgment (1)
- justice sensitivity (1)
- juvenile idiopathic arthritis (1)
- kINPen MED (1)
- kINPen plasma jet (1)
- kINpen (1)
- kappa free light chains (1)
- kappa-free light chains (KFLC) (1)
- keratinocytes (1)
- ketoreductase (1)
- keystone taxa (1)
- kidney biopsy (1)
- kidney-on-a-chip (1)
- kinase inhibitors (1)
- kinetic resolution (1)
- kinetics (1)
- knock-out (1)
- knowledge transfer (1)
- knowledge-is-power (1)
- kurstakin (1)
- kynurenines (1)
- label-free quantification (1)
- label-free quantitation (1)
- laboratory (1)
- laboratory mice (1)
- laboratory parameters (1)
- laboratory workflow (1)
- labour market attachment (1)
- lacewing larva (1)
- lack of concentration (1)
- lack of energy (1)
- lactoperoxidase (1)
- lake restoration. nutrient load reduction (1)
- lake sediments (1)
- lake-level fluctuations (1)
- lake‐level variations (1)
- laminarin (1)
- land conversion (1)
- land degradation (1)
- land snails (1)
- land system (1)
- land use and land cover change (1)
- land use change (1)
- landscape abundance (1)
- land‐use intensity (1)
- language attitudes (1)
- language disorders (1)
- language processing (1)
- language use (1)
- large cohort data (1)
- larval fish (1)
- larval fishes (1)
- laser ablation (1)
- laser coagulation (1)
- laser photodesorption (1)
- laser spectroscopy (1)
- laser surface texturing (1)
- late Holocene (1)
- late onset MS (1)
- late onset seizures (1)
- late-onset (1)
- latency (1)
- latent change model (1)
- latent class (1)
- latent class analysis (1)
- latent class model (1)
- latent class models (1)
- latewood blue intensity (1)
- lead compounds (1)
- lead structure (1)
- leadership (1)
- leaf (1)
- leaf phenology (1)
- leaf senescence (1)
- leaf-branch compost (1)
- leaf-wax (1)
- leafy greens (1)
- learned helplessness (1)
- learning (1)
- learning environment (1)
- learning objectives (1)
- left-sided colon cancer (1)
- leiomyosarcoma (1)
- length (1)
- lethal dose 50 (1)
- leukemia (1)
- leukocidins (1)
- leukocyte activation (1)
- level of care (1)
- levetiracetam (1)
- levofloxacin (1)
- liberal democracy (1)
- lichen-associated bacteria (1)
- lichens (1)
- lidocaine (1)
- life-span development (1)
- life‐history traits (1)
- ligand-transporter interaction (1)
- ligation (1)
- light intensity (1)
- light intensity (irradiance) (1)
- light pollution (1)
- light-sheet imaging (1)
- lignin (1)
- limbs (1)
- lineage‐specific region (1)
- linear discriminant analyses (1)
- linear gradient (1)
- linear mixed model (1)
- lipase (1)
- lipid metabolism (1)
- lipid monolayer (1)
- lipid profile (1)
- lipidation (1)
- lipofilling (1)
- lipogenesis (1)
- lipopeptides (1)
- lipoprotein (1)
- lipoprotein profile (1)
- lipoprotein profiling (1)
- lipoproteins (1)
- liposomes (1)
- liquid chromatography-mass spectrometry (1)
- liquid-liquid extraction (1)
- literature (1)
- live birth (1)
- live/dead cell imaging (1)
- liver failure (1)
- liver fat content (1)
- liver fibrosis (1)
- liver inflammation (1)
- liver metastasis (1)
- liver pathology (1)
- liver regeneration (1)
- liver support (1)
- liver transplantation (1)
- livestock (1)
- livestock keeping (1)
- lncRNA (1)
- local drug targeting (1)
- localization (1)
- lockdowns (1)
- locus coeruleus (1)
- logarithmic function (1)
- long COVID (1)
- long-read sequencing (1)
- long-term (1)
- long-term follow-up (1)
- long-term infusion (1)
- long-term potentiation (1)
- longitudinal (1)
- longitudinal cohort study (1)
- longitudinal research (1)
- longitudinal sound change (1)
- long‐term home care (1)
- lottocracy (1)
- low and mid income countries (1)
- low-carbon behavior (1)
- low-grade inflammation (1)
- low-temperature plasma polymerization (1)
- low‐temperature plasma (1)
- luciferase (1)
- luciferase reporter gene assay (1)
- lumen area (1)
- luminescence dating (1)
- luminescence profiling (1)
- lung metastases (1)
- lymphedema (1)
- lymphocyte-activation gene 3 (1)
- lysine acetylation (1)
- lysine acetyltransferases (1)
- lysine deacetylases (1)
- lysosomal biogenesis (1)
- m6A (1)
- mHealth (1)
- mQTL (1)
- mTORC1 (1)
- mTor (1)
- maar lake (1)
- macaques (1)
- macro-remains (1)
- macroH2A (1)
- macrodomain (1)
- macroecology (1)
- macrophage (1)
- macrovascular disease (1)
- magnesia (1)
- magnetic characterization methods (1)
- magnetic fields (1)
- magnetic marker monitoring (1)
- magnetic materials (1)
- magnetic microscopy (1)
- magnetic moment (1)
- magneto-hydrodynamic equilibrium (1)
- magneto-optical effects (1)
- magneto-optics (1)
- magnetron sputtering discharge (1)
- maintenance (1)
- malignancy (1)
- malignant transformation (1)
- mallard ducks (1)
- mamma carcinoma (1)
- mammals (1)
- mammography (1)
- management (1)
- management measures (1)
- manganese (1)
- manganese oxide (1)
- manual assembly (1)
- manufacturing science (1)
- mapping (1)
- marine bacteria (1)
- marine biodegradation (1)
- marine polysaccharides (1)
- market analysis (1)
- mass spectometry (1)
- mass spectrometer (1)
- mast (1)
- mast cell (1)
- mate choice (1)
- materials science (1)
- maternal breast milk (1)
- maternal health care (1)
- mathematical model (1)
- mating success (1)
- matrix metalloproteinase (1)
- matter fluxes (1)
- maxillofacial (1)
- maximum latewood density (1)
- maximum parsimony (1)
- maximum performance (1)
- maximum plant height (1)
- meaning in life (1)
- measurement error (1)
- measurement system analysis (1)
- measurement/psychometrics (1)
- mechanical circulatory support (1)
- mechanical stability (1)
- mechanism (1)
- mechanoreception (1)
- media education (1)
- media representation (1)
- mediatation (1)
- mediation (1)
- medical assistants (1)
- medical education (1)
- medical gas plasma technology (1)
- medicinal herbs (1)
- medicinal plants (1)
- medicine (1)
- melamine-formaldehyde (1)
- melatonin (1)
- membrane functionality (1)
- membrane integrity (1)
- membrane protein (1)
- membrane proteins (1)
- membrane transport (1)
- membrane transporters (1)
- membranous-cytoplasmic EGFR (1)
- memory performance (1)
- mendelian randomization analysis (1)
- menopause (1)
- mental health stigmatisation (1)
- mental representations (1)
- mental rotation (1)
- mental transformations (1)
- mental workload (1)
- mercury (1)
- mesenteric artery (1)
- mesoionic carbenes (1)
- messianic tradition (1)
- metabolic activity (1)
- metabolic network (1)
- metabolic phenotypes (1)
- metabolic processes (1)
- metabolic subtypes (1)
- metabolism under glucose starvation (1)
- metabolite (1)
- metabolites (1)
- metabotypes (1)
- metacognition (1)
- metacognitive beliefs (1)
- metacognitive therapy (1)
- metaflammasome (1)
- metal oxides (1)
- metaproteome (1)
- metastatic colorectal cancer (1)
- metatranscriptomics (1)
- metaviromics (1)
- metformin (1)
- methanogenesis (1)
- methanogenic archaea (1)
- methanogens (1)
- methanotrophic bacteria (1)
- methanotrophs (1)
- methicillin-resistant <i>Staphylococcus aureus</i> (1)
- methodology (1)
- methods in liquid biopsy (1)
- methyltransferases (1)
- methyltryptophan (1)
- metrological controls (1)
- metrology (1)
- miR-205-5p (1)
- miRNA transcriptome (1)
- miRNA-Seq (1)
- miR‐21 (1)
- micelle (1)
- micro-CT (1)
- micro-remains (1)
- microRNA sequencing (1)
- microbial communities (1)
- microbial community (1)
- microbial diversity; (1)
- microbial function (1)
- microbiome heterogeneity (1)
- microblogging (1)
- microcontact printing (1)
- microcore (1)
- microdialysis (1)
- microdischarge (1)
- microfluidic (1)
- microfluidic device (1)
- microgravity research (1)
- microorganisms (1)
- micropatterns (1)
- microphysiological systems (1)
- microsite (1)
- microvascular flow (1)
- microvasculature (1)
- microwave (1)
- microwave-driven discharge (1)
- midazolam (1)
- middle school students (1)
- midostaurin (1)
- migration (1)
- migratory physiology (1)
- mild cognitive impairment (1)
- milk analysis (1)
- milk bank (1)
- milk pools (1)
- mincing (1)
- mindreading (1)
- mine drainage (1)
- mineral soil (1)
- mini tablets (1)
- minigene (1)
- minimal area (1)
- minimal inhibitory concentration (1)
- minipublics (1)
- minirhizotrons (1)
- mire type (1)
- mitigation (1)
- mitochondrial dynamics (1)
- mitochondrial fission (1)
- mitochondrial membrane potential (1)
- mitochondrial respiration (1)
- mitophagy (1)
- mixed-valence complex (1)
- moDCs (1)
- mobile health (1)
- mobile learning (1)
- mobility (1)
- mode comparison (1)
- modeling (1)
- moderator (1)
- modern experimental methods (1)
- modernisation (1)
- modifier gene (1)
- molar incisor hypomineralization (1)
- molecular absorption spectrometry (1)
- molecular biology (1)
- molecular carcinogenesis (1)
- molecular dynamics simulations (MDS) (1)
- molecular epidemiology (1)
- molecular imaging (1)
- molecular ion formation (1)
- molecular mechanics (1)
- molecular modeling (1)
- molecular phylogenetics (1)
- molecular simulation (1)
- molecular weight (1)
- molluscs (1)
- molybdenum complexes (1)
- momentary assessment (1)
- money allocation (1)
- monocarboxylate transporter 1 (1)
- monocarboxylate transporter 8 (1)
- monocyte subpopulation (1)
- monoterpene (1)
- monoterpene acylation (1)
- moonlighting proteins (1)
- moral decision making (1)
- moral dilemmas (1)
- moral emotions (1)
- moral judgment (1)
- moral reasoning (1)
- morbidity (1)
- morcellement (1)
- morphological crypsis (1)
- morphometrics (1)
- morphometry (1)
- mortality costs (1)
- motives (1)
- motor (1)
- motor cortex (1)
- motor evoked potentials (1)
- motor function (1)
- motor outcome (1)
- motor skills (1)
- mouse Ntcp (1)
- mouth rinse (1)
- moving study (1)
- mucoadhesion (1)
- mucoadhesive films (1)
- mucoadhesive polymer (1)
- mucosa model (1)
- mucosal diseases (1)
- mucosal immunity (1)
- mucositis (1)
- mucus (1)
- multi drug resistance (1)
- multi-criteria decision analysis (1)
- multi-media (1)
- multi-omic (1)
- multi-scale entropy (MSE) (1)
- multi-species biofilm (1)
- multicomponent mixtures (1)
- multidisciplinary pain treatment (1)
- multidrug resistance (1)
- multidrug resistant (1)
- multidrug-resistance (1)
- multidrug-resistant microorganisms (1)
- multigroup latent moderated structural equations (1)
- multilayers (1)
- multilevel analyses (1)
- multilevel analysis (1)
- multilevel perspective (1)
- multimodal data (1)
- multimodal integration (1)
- multimorbidity (1)
- multiphoton imaging (1)
- multiple current pulses (1)
- multiple myeloma (1)
- multiple organ failure (1)
- multiple resource limitation (1)
- multiple sequence alignment (1)
- multispectral satellite imagery (1)
- multitasking (1)
- multivariate regression analysis (1)
- multiview geometry (1)
- multi‐year flooding cycle (1)
- mupirocin (1)
- murine pancreatic carcinoma model (1)
- muscle atrophy (1)
- muscle ring finger protein 1 (1)
- muscle sparing (1)
- muscle spindle (1)
- muscle wasting (1)
- muscular dystrophy (1)
- musculature (1)
- mussel cultivation (1)
- mutation correction (1)
- mutlinucleon transfer (1)
- mycoses (1)
- myelodysplastic syndrome (1)
- myeloid differentiation factor 2 (1)
- myeloproliferative neoplasms (1)
- myeloproliferative neoplasms (MPN) (1)
- myogenic vasoconstriction (1)
- myrmecomorphy (1)
- mystical prayer (1)
- nLC-MS/MS (1)
- nanocapsules (1)
- nanoemulgel (1)
- nanoindentation (1)
- nanomanipulation (1)
- nanopore sequencing (1)
- nanosecond-pulsed streamer (1)
- naphthoquinones (1)
- narrative (1)
- narrative interviews (1)
- nasal microbiome (1)
- nasopharynx (1)
- natural resources (1)
- naturalistic (1)
- nauplii (1)
- navigation (1)
- navy vessels (1)
- ncRNA (1)
- near-hand space (1)
- nearshore bar formation (1)
- necrosis (1)
- neglect (1)
- nematicity (1)
- neovascularisation (1)
- nephrotoxicity (1)
- nested‐plot sampling (1)
- networks (1)
- neural (1)
- neural antibodies (1)
- neural circuits and behavior (1)
- neural correlates of attachment representation borderline personality disorder (1)
- neural stem cell (1)
- neuroactive steroids (1)
- neuroanatomy (1)
- neuroblast (1)
- neurocognitive disorders (1)
- neurodegenerative diseases (1)
- neurodevelopmental disorders (1)
- neuroendocrine tumors (1)
- neurofilament (1)
- neuroimaging (1)
- neuroimmune interactions (1)
- neurological diseases (1)
- neuropathic pain (1)
- neuropathy (1)
- neurophysiology (1)
- neuroplasticity (1)
- neuroprotection (1)
- neuropsychiatric diseases (1)
- neuropsychological (1)
- neurorehabilitation (1)
- neurospheres (1)
- neurosteroids (1)
- neurosurgical treatment (1)
- neurotoxicity (1)
- neurotrophic factors (1)
- neutral recycling (1)
- neutron-rich nuclei (1)
- new politics (1)
- new speakers (1)
- newborn screening (1)
- nexus archetype (1)
- niche evolution (1)
- niche following (1)
- nicotinamide (1)
- night shift work (1)
- nisin (1)
- nitrate (1)
- nitrite (1)
- nitrogen (1)
- nitrogen deficiency (1)
- nitrosative stress (1)
- no-net-loss (1)
- non-MS patients (1)
- non-PCV13 serotypes 2 (1)
- non-attendance (1)
- non-canonical UBL (1)
- non-homologous end joining (1)
- non-human primates (1)
- non-identical reversible reaction (1)
- non-interventional (1)
- non-invasive (1)
- non-invasive brain stimulation (1)
- non-native populations (1)
- non-pollen palynomorphs (1)
- non-randomized studies (1)
- non-thermal plasma (1)
- non-thermal processing (1)
- nonhuman primates (1)
- noninvasive DNA (1)
- noninvasive sampling (1)
- nonlinear regression (1)
- norepinephrine (1)
- nortriptyline (1)
- nose (1)
- nosocomial infection (1)
- novel (1)
- novel immunotherapy (1)
- no‐matched templates (1)
- nuclear EGFR (1)
- nuclear receptors (1)
- nuclease (1)
- nucleophilic substitution (1)
- nucleoredoxin (1)
- nucleus accumbens (1)
- number of missing teeth (1)
- numerical modeling (1)
- numerical simulation (1)
- nurse–patient interaction (1)
- nurse–patient relationship (1)
- nursing home (1)
- nursing workforce (1)
- nutrients (1)
- nutrients elements (1)
- nutrition (1)
- object-location memory (1)
- objective measures (1)
- observational (1)
- obstructive sleep apnea syndrome (1)
- occlusal adjustment (1)
- occlusal equilibration (1)
- occlusive vasculitis (1)
- ocean history (1)
- ocean sustainability (1)
- octogenarians (1)
- octopus (1)
- offspring (1)
- oil (1)
- oil palm plantation (1)
- old patient (1)
- olfaction (1)
- olfactory (1)
- olfactory system (1)
- oligoclonal IgG (1)
- oligoclonal bands (1)
- oligodendrocyte precursor cells (1)
- oligomeric proanthocyanidines (1)
- oligonucleotides (1)
- oligotroph (1)
- olive mill wastewaters valorization (1)
- omics (1)
- oncohistone (1)
- one health (1)
- ong-chainaliphaticamines (1)
- online experiment (1)
- online sample preparation (1)
- open data (1)
- open materials (1)
- open source (1)
- operating room scheduling (1)
- operative (1)
- optical emission and absorption spectroscopy (1)
- optical emission spectroscopy (1)
- optical imaging analyses (1)
- optimized screening (1)
- optochin susceptibility testing (1)
- oral cancer (1)
- oral health (1)
- oral microbiome (1)
- oral mucosal lesions (1)
- oral nutritional supplement (1)
- oral rehydration solution (1)
- orb web (1)
- orbital soft tissue injury (1)
- orbital trauma (1)
- orcokinin (1)
- ordinal regression (1)
- ordinal regression model (1)
- ordinal time series (1)
- organic anion transporters (1)
- organic cation transporter 2 (1)
- organic farming (1)
- organic matter loss (1)
- organic soil (1)
- organic synthesis (1)
- orofacial pain (1)
- orosomucoid (1)
- orphan diseases (1)
- ortholog comparison (1)
- osmostress protectants (1)
- osmotic stress (1)
- osmotolerance (1)
- osseointegration (1)
- osteoarthritis disease modification (1)
- osteoblasts (1)
- osteogenic differentiation (1)
- osteosarcoma cells (1)
- ostracodes (1)
- outbreak management (1)
- outer membrane vesicles (1)
- outpatient (1)
- overfishing (1)
- overflow metabolites (1)
- oversight (1)
- ovine anaplasmosis (1)
- oxaliplatin (1)
- oxidation-specific epitopes (1)
- oxidative dysbalance (1)
- oxidative post-translational modifications (1)
- oxidized lipids (1)
- oxidoreductases (1)
- oxygen uptake (1)
- p-coumaric acid (1)
- p38 (1)
- pH optimum (1)
- pair plasma (1)
- palaeoclimate (1)
- palaeoecology (1)
- palaeosol (1)
- paleoenvironment (1)
- paleoenvironmental changes (1)
- paleomagnetic secular variations (1)
- palpal organ (1)
- pan-cancer (1)
- pancreatic (1)
- pancreatic beta cells (1)
- pancreatic cancer (1)
- pancreatic carcinoma (1)
- pancreatic surgery (1)
- pancreatojejunostomy (1)
- panniculitis (1)
- papain-like protease (1)
- papilloma (1)
- paramagnetic particles (1)
- parental cancer (1)
- parental gender preferences (1)
- parental leave (1)
- parental pressure (1)
- parental support (1)
- parenteral nutrition (1)
- parents (1)
- parietal lobe (1)
- parliaments (1)
- parotid gland (1)
- parotid gland tumors (1)
- partial mutual information (1)
- particle (1)
- particle tracking (1)
- particle transport (1)
- particle-in-cell (1)
- parties (1)
- partisan preferences (1)
- passive sensing (1)
- patent ductus arteriosus (1)
- paternity assignment (1)
- pathogen vacuole (1)
- pathogen-specific IgG (1)
- pathogens (1)
- patient (1)
- patient participation (1)
- patient-derived xenografts (1)
- patient‐reported outcome measures (PROM) (1)
- pattern (1)
- pattern and process (1)
- patterned discharge (1)
- pazopanib (1)
- peak oxygen uptake (1)
- peat (1)
- peat degradation (1)
- peat extraction (1)
- peat fire (1)
- peat moss (1)
- peatland management (1)
- pedagogical agents (1)
- pediatric (1)
- pediatric dental treatment (1)
- pediatric intestinal failure (1)
- pediatric oncology and hematology (1)
- pediatric short bowel syndrome (1)
- pediatric thrombosis (1)
- pediatrician (1)
- pediatrics (1)
- peer support (1)
- peers (1)
- peers as positive motivators (1)
- pelagites (1)
- penning trap mass spectrometer ISOLTRAP (1)
- penta-acylated lipid A (1)
- pentathiepin (1)
- peptidases (1)
- peptide (1)
- peptide analysis (1)
- peptidome (1)
- peracarida (1)
- perceived stress scale PSS-10 (1)
- perception (1)
- perceptual theory of emotion (1)
- percutaneous coronary intervention (1)
- performance (1)
- performance assessment (1)
- perfusion (1)
- perfusion measurements (1)
- perianal disease (1)
- perinatal (1)
- periodontal attachment loss (1)
- periodontal disease (1)
- periodontal diseases (1)
- periodontal pocket (1)
- periodontal splinting (1)
- perioperative care (1)
- perioperative supportive measures (1)
- peripersonal space (1)
- peripheral nervous system (1)
- periplasm (1)
- periprosthetic joint infection (1)
- peristalsis (1)
- permafrost (1)
- permeabilizer (1)
- permutation (1)
- peroxynitrite (1)
- person ability (1)
- person-centered care (1)
- personal data (1)
- personal force (1)
- personalised medicine (1)
- personality (1)
- personality disorders (1)
- personality traits (1)
- personalized implant (1)
- personalized medicine (1)
- personalized psychotherapy (1)
- perspective taking (1)
- pesticide and drug interaction (1)
- phagocyte oxidase (1)
- phagocytosis (1)
- pharmacoepidemiology (1)
- pharmacokinetic modeling (1)
- pharmacokinetic/pharmacodynamic parameters (1)
- pharmacological chaperone (1)
- pharmacy education (1)
- pharmacy students (1)
- phase constancy (1)
- phase resolved surface charge measurement (1)
- phenolic compounds (1)
- phenology (1)
- phenotyping (1)
- phenylalanine ammonia lyase (1)
- philosophy (1)
- philosophy of emotion (1)
- phobia/phobic disorders (1)
- phonon localization (1)
- phonon propagation (1)
- phosphanes (1)
- phosphatases (1)
- phosphopeptide enrichment (1)
- photopharmacology (1)
- photoresponse (1)
- photoswitches (1)
- photosynthetic rate (1)
- photosystem (1)
- photovoltaics (1)
- phylodynamics (1)
- phylogenetic analysis (1)
- phylogenomics (1)
- phylogeny (1)
- phylogeography (1)
- physical function (1)
- physical health (1)
- physical plasma (1)
- physicians (1)
- physicochemical characterization (1)
- physicochemical factors (1)
- physiology (1)
- physiotherapy (1)
- phytochemicals (1)
- phytoplankton communities (1)
- phytosterols (1)
- phytotherapy (1)
- pig model (1)
- pigment (1)
- pigment composition (1)
- pinch (1)
- pituitary surgery (1)
- place and space (1)
- planctomycetes (1)
- plant biodiversity (1)
- plant clonality (1)
- plant growth promotion (PGP) (1)
- plant pathogen (1)
- plant traits (1)
- plant–environment interaction (1)
- plant–insect interaction (1)
- plant–soil feedback (1)
- plaque characteristics (1)
- plasma applications (1)
- plasma biomarker (1)
- plasma chemistry (1)
- plasma confinement (1)
- plasma devices (1)
- plasma diagnostic (1)
- plasma diagnostics (1)
- plasma discharge (1)
- plasma in liquids (1)
- plasma instabilities (1)
- plasma jet (1)
- plasma material processing (1)
- plasma modeling (1)
- plasma oncology (1)
- plasma science and technology (1)
- plasma sheaths (1)
- plasma simulation (1)
- plasma sources (1)
- plasma-fluorocarbon-polymer (1)
- plasma-treated water (1)
- plasminogen plasmin system (1)
- plastic pollution (1)
- plasticity (1)
- platelet aggregation (1)
- platelet pathophysiology (1)
- platelet transfusion proteomics (1)
- platelet-rich plasma (1)
- platelet–monocyte aggregates (1)
- plume (1)
- pneumococcal carriage (1)
- pneumococcal colonization (1)
- pneumococcal proteins (1)
- pneumococcal serine protease (1)
- poaching (1)
- podcast (1)
- podocyte nephropathy (1)
- poetry and historiography (1)
- political parties (1)
- pollen (1)
- pollen accumulation rates (1)
- pollen analysis (1)
- poly-(L-lactide); (1)
- polyarthritis (1)
- polycythemia vera (PV) (1)
- polyelectrolyte multilayer (1)
- polyethylene terephthalate (1)
- polymer extension (1)
- polymerase theta (1)
- polymicrobial sepsis (1)
- polymorphisms (1)
- polypharmacology (1)
- polypharmacy (1)
- polyreactive antibodies (1)
- polysomnography (1)
- polyspecificity (1)
- polytrauma (1)
- poorly soluble drug (1)
- poorly soluble drugs (1)
- population analysis (1)
- population cycles (1)
- population dynamics (1)
- population genomics (1)
- population-based (1)
- population-based studies (1)
- population‐based birth cohort (1)
- population‐based study (1)
- porcine skin model (1)
- porcine small intestine (1)
- porphyran (1)
- portal hypertension (1)
- position-taking view of emotion (1)
- positive and negative feedback (1)
- positively biased anode (1)
- positives und negatives Feedback (1)
- post-COVID-19-syndrome (1)
- post-translational modifications (1)
- postacute care (1)
- postoperative analgesia (1)
- postoperative cognitive dysfunction (1)
- postoperative delirium (1)
- postoperative pancreatic fistula (1)
- posttranslational modification (PTM) (1)
- potential methane oxidation rates (1)
- potential natural vegetation (1)
- poultry (1)
- power law (1)
- powered tooth brush (1)
- powered toothbrush (1)
- practice-based evidence (1)
- pre-ionization (1)
- pre-neoplastic lesions (1)
- pre-symptomatic Alzheimer’s disease marker (1)
- preclinical Alzheimer's disease (1)
- predator-prey syn-inclusion (1)
- prediabetes (1)
- prediabetic state (1)
- prediction error (1)
- prediction model (1)
- prediction modelling (1)
- predictive marker (1)
- predictor (1)
- pregnenolone sulfate (1)
- preneoplastic foci (1)
- preoperative anxiety (1)
- preoperative risk assessment (1)
- preoperative workflow (1)
- preregistered (1)
- preterm (1)
- preterm infants (1)
- pretreatment (1)
- preventive medicine (1)
- prey (1)
- primary immunodeficiency disease (1)
- primary macrophages (1)
- primary motor cortex (1)
- primary myelofibrosis (PMF) (1)
- primary teeth (1)
- priming (1)
- principal component analyses (1)
- privacy concerns (1)
- pro-environmental behaviors (1)
- pro-environmental ideology (1)
- pro-environmental intention (1)
- proactive coping: turnover (1)
- probing depth (1)
- problem solving (1)
- proceduralism (1)
- process dissociation procedure (1)
- process-based modeling (1)
- production-integrated compensation (1)
- productivity (1)
- productivity traits (1)
- profile hidden Markov model (1)
- profitability (1)
- progesterone (1)
- prognostic marker (1)
- prognostic model (1)
- progression (1)
- progression-free survival (1)
- progressive MS (1)
- proinflammatory cytokines (1)
- project management (1)
- project report (1)
- prolonged release (1)
- promoter (1)
- propranolol HCl (1)
- proprioception (1)
- prospective (1)
- prospective cohort study (1)
- prostate-specific antigen (1)
- prostatic neoplasms (1)
- protease activity (1)
- protease-activated receptors (1)
- proteasome associated autoinflammatory syndrome (1)
- proteasome endopeptidase complex (1)
- proteasome inhibitors (PIs) (1)
- proteasome-associated autoinflammatory syndrome (1)
- proteasomopathy (1)
- protected area (1)
- protein degradation (1)
- protein expression and purification (1)
- protein folding (1)
- protein kinase D (1)
- protein preparation (1)
- protein production (1)
- protein quantification (1)
- protein synthesis (1)
- protein-protein docking (1)
- protein–protein interaction (1)
- proteostasis in skeletal muscle (1)
- protists (1)
- protocatechuic acid (1)
- protocol (1)
- proton insertion (1)
- proton pump inhibitor (1)
- prototype (1)
- psoriasis (1)
- psychiatric disorders (1)
- psychiatric rehabilitation (1)
- psychiatry (1)
- psycho-physiological interaction (1)
- psychological factors (1)
- psychological profile (1)
- psychological refractory period (PRP) (1)
- psychometric testing (1)
- psychometrics (1)
- psychosocial needs (1)
- psychosocial stress (1)
- public engagement (1)
- public warning (1)
- public warning systems (1)
- pulmonary arterial pressure (1)
- pulmonary endarterectomy (1)
- pulmonary function tests (1)
- pulmonary vascular resistance (1)
- pulse length dependence (1)
- pulse oximetry (1)
- pulsed laser deposition (1)
- pulsed power (1)
- pump-probe spectroscopy (1)
- pyramidal tract integrity (1)
- pyrimidine (1)
- pyrogenic toxin superantigens (1)
- pyruvate (1)
- pyruvate kinase (1)
- qRT-PCR (1)
- quadratic number field (1)
- qualitative analysis (1)
- quality assurance (1)
- quality improvement (1)
- quantitative and qualitative Aichi targets (1)
- quantitative image analysis (1)
- quantum corrections (1)
- quantum dots (1)
- quantum mechanics (1)
- quasi-essential (1)
- quasi-experimental online-study (1)
- quasi-two-dimensional systems (1)
- quercetin (1)
- questing tick (1)
- quinolines (1)
- quizartinib (1)
- radial growth (1)
- radiation detection (1)
- radiation doses (1)
- radical cation (1)
- radical reactions (1)
- radicular cyst (1)
- radiocarbon dating (1)
- radiology in Germany (1)
- radiometric interpolation (1)
- radiomics (1)
- radiotherapy (1)
- radium isotope (1)
- radius cell migration assay (1)
- random forest (1)
- random forests (1)
- random mutagenesis (1)
- random noise stimulation (1)
- randomization (1)
- randomized controlled trials (1)
- range dynamics (1)
- range margin (1)
- range shift (1)
- ranibizumab (1)
- rapamycin (1)
- rapid adaptation (1)
- rapid test (1)
- rapid testing (1)
- rare disease (1)
- rat (1)
- rat hepatocytes (1)
- rater (1)
- rating (1)
- rating scale (1)
- rational design (1)
- re-establishment (1)
- re-growth (1)
- re-wetting (1)
- reactivation (1)
- reactive mode (1)
- reactive species (1)
- ready-to-eat produce (1)
- real‐time deformability cytometry (1)
- receptive multilingualism (1)
- reciprocal transplant experiment (1)
- reciprocal transplantation experiment (1)
- recombinant protein (1)
- recommendation (1)
- reconstitution (1)
- reconstruction (1)
- recruitment curve steepness (1)
- rectus sparing (1)
- recurrence (1)
- recycling (1)
- red foxes (1)
- redox (1)
- redox biology (1)
- redox chemistry (1)
- redox metabolism (1)
- redox potential (1)
- reductant (1)
- reduction (1)
- reduction strategies (1)
- reed beds (1)
- regenerative medicine (1)
- regime shift (1)
- regional approach (1)
- regional language (1)
- regional polarization (1)
- regional policy (1)
- regional sustainable development (1)
- regioselectivity (1)
- register (1)
- registry (1)
- registry-based analysis (1)
- regression analysis (1)
- regulatory B cells (1)
- regulatory gene (1)
- regulatory monocytes (1)
- regulatory network (1)
- reinforcement learning (1)
- rejection sensitivity (1)
- relatedness (1)
- relatedness with peers (1)
- relative entropy (1)
- remission (1)
- remittances (1)
- remote teaching (1)
- renal denervation (1)
- renal dysfunction (1)
- renal pathology (1)
- renal physiology (1)
- renewable energies (1)
- renewable resource (1)
- renin-angiotensin system (1)
- reoxygenation (1)
- repair mechanism (1)
- repeated phenological ranking (1)
- replica-exchange molecular dynamics (1)
- replicability (1)
- reporting (1)
- repository (1)
- representative sample (1)
- repressor proteins (1)
- reproducibility (1)
- reproducibility of results (1)
- reproducible research (1)
- reproduction (1)
- reproductive ecology (1)
- reproductive health (1)
- reproductive success (1)
- research (1)
- research participation (1)
- reserve (1)
- reservoir (1)
- resident (1)
- resilience (1)
- resin (1)
- resistance detection (1)
- resistance genes (1)
- resistive ballooning (1)
- resistome (1)
- resonance ionization (1)
- resource availability (1)
- resource utilization (1)
- respiration (1)
- respiratory tract infection (1)
- responders/non-responders (1)
- response bias (1)
- responsibility (1)
- rest break (1)
- resting-state-fMRI (1)
- resveratrol (1)
- retina (1)
- retinal vasculitis (1)
- retinol‐binding protein 4 (1)
- revegetation (1)
- review (1)
- review – systematic (1)
- rheumatoid arthritis (1)
- rhinovirus (1)
- rhinovirus A (1)
- rhinovirus B (1)
- rhinovirus C (1)
- rhodanese (1)
- ribozyme (1)
- ribozymes (1)
- rice husk (1)
- rifampicin/minocycline (1)
- right heart catheter (1)
- right-sided colon cancer (1)
- ring-opening reactions (1)
- ring-width (1)
- risk adjustment (1)
- risk appraisal (1)
- risk aversity (1)
- risk evaluation (1)
- risk factor (1)
- risk factor progression (1)
- risk perception (1)
- risk-adapted prevention (1)
- roadmap (1)
- robot therapy (1)
- robustness (1)
- rodents (1)
- roentgen rays (1)
- root phenology (1)
- root system (1)
- rosuvastatin (1)
- rotating magnetic field (1)
- rotifers (1)
- routine data (1)
- routine outcome monitoring and feedback (1)
- routine surveillance data (1)
- rs3747742 (1)
- rs56149945 (1)
- rubber plantation (1)
- rule changes (1)
- rural (1)
- rural area (1)
- rural regions (1)
- ryanodine receptors (1)
- sTREM2 (1)
- safety (1)
- salinity (1)
- salinity acclimation (1)
- salinity changes (1)
- saliva flow (1)
- salivary alpha-amylase (1)
- salivary gland volume (1)
- salivary tracer (1)
- sample bias (1)
- sample storage (1)
- sarcomere (1)
- sarcopenia (1)
- sartorius sparing (1)
- scaffolding (1)
- scaffolds (1)
- scaling (1)
- scaling law (1)
- scanning ion conductance microscopy (1)
- scattering processes (1)
- schizophrenia (1)
- scholarly communication (1)
- school absenteeism (1)
- school burnout (1)
- school children (1)
- school environment (1)
- school principals (1)
- school self-concept (1)
- schools and pre-schools (1)
- science communication (1)
- scientist (1)
- scintigraphy (1)
- screening tool (1)
- sea spider (1)
- sea urchins (1)
- sea-level change (1)
- seagrass microbiome (1)
- seasonal (1)
- seasonal variation (1)
- secondary electron emission coefficient (1)
- secondary occlusal trauma (1)
- secondary-school students (1)
- second‐line (1)
- secretory renin (1)
- secularisation (1)
- securitization (1)
- sedation (1)
- sedentarism (1)
- sedge peat (1)
- sedimentology (1)
- seed bank (1)
- seed electrons (1)
- seed germination (1)
- seed rain (1)
- seedling (1)
- selective migration (1)
- selectivity (1)
- self-care (1)
- self-efficacy (1)
- self-efficacy beliefs (1)
- self-injurious behavior (1)
- self-organization (1)
- self-regulated learning (1)
- self-report (1)
- self-similar (1)
- self‐competence/self‐efficacy (1)
- self‐efficacy (1)
- semantic network (1)
- semantic roles (1)
- semi-arid (1)
- semi-arid Mongolia (1)
- semiautomated image analysis (1)
- senescence (1)
- senolytics (1)
- sensitization (1)
- sensorimotor (1)
- sensory (1)
- sensory ecology (1)
- sensory impairments (1)
- sensory processing sensitivity (1)
- sentinel (1)
- separatrix (1)
- sepsis patients (1)
- septic arthritis (1)
- sequence learning (1)
- serial block-face scanning electron microscopy (SBFSEM) (1)
- serine proteases (1)
- serine proteinases (1)
- serious adverse events (1)
- serious adverse reaction (1)
- serology (1)
- serotonin (1)
- serotonin release assay (1)
- serotypes (1)
- serum (1)
- serum biomarker (1)
- serum markers (1)
- serum starvation (1)
- severe weather (1)
- severely injured (1)
- sex steroids (1)
- sex- specificity (1)
- sex-based difference (1)
- sex-specific (1)
- sex-specific differences (1)
- sexting (1)
- sexual dimorphism (1)
- sexual health (1)
- sexual selection (1)
- shade taking (1)
- shared decision making (1)
- shear flow (1)
- shear stress (1)
- sheep (1)
- shoot nitrogen content (1)
- shotgun-proteomics (1)
- sick days (1)
- sidedness (1)
- sifap1 (1)
- sigma factor σW (1)
- signal transduction (1)
- silk (1)
- silver (1)
- silver nanoparticles (1)
- similarity (1)
- similarity laws (1)
- simulations (1)
- single nucleotide polymorphism (SNP) (1)
- single nucleotide polymorphisms (1)
- single-digit addition (1)
- sirtuin (1)
- sirtuins (1)
- site-specific application (1)
- site-specific drug delivery (1)
- situated ignorance (1)
- six-minute walking test (6-MWT) (1)
- skeletal regeneration (1)
- skill mix (1)
- skin and soft-tissue infections (1)
- skin conductance (1)
- skyrmions (1)
- slaughterhouse (1)
- sleep (1)
- sleep apnea (1)
- sleep disorders (1)
- sleep macro-architecture (1)
- sleep quality (1)
- sleep stages (1)
- sleep-disordered breathing (1)
- slime molds (1)
- slow-wave sleep (1)
- small RNA (1)
- small cell numbers (1)
- small language (1)
- small-compound databases (1)
- smallholder (1)
- smectite alteration (1)
- smile expressions (1)
- snoD mutant (1)
- snoRNAs (1)
- social anxiety disorder (1)
- social arthropods (1)
- social belonging (1)
- social change (1)
- social distance (1)
- social evidence (1)
- social inequality (1)
- social interaction (1)
- social isolation (1)
- social networking (1)
- social pain (1)
- social participation (1)
- social relationships in school (1)
- social skills (1)
- social support (1)
- social-ecological system (1)
- social-ecological systems (1)
- sociality and health (1)
- socio-economic analyses (1)
- socio-motivational relationships (1)
- sociolinguistic approach (1)
- sociology of science (1)
- sodium (1)
- sodium fluorescein (1)
- soil erosion (1)
- soil legacy effects (1)
- soil microbiome (1)
- soil organic carbon stock (1)
- soil proteins (1)
- soil temperature (1)
- solar variability (1)
- solenoid separator (1)
- solid oxide fuel cells (1)
- solid tumor models (1)
- soluble guanylyl cyclase (1)
- soluble guanylyl cyclase activator (1)
- soluble guanylyl cyclase stimulator (1)
- solute carriers (1)
- somatization (1)
- sortase A (1)
- sound (1)
- source of transmission (1)
- soy isoflavones (1)
- soziale Fähigkeiten (1)
- spatial accessibility (1)
- spatial analysis (1)
- spatial clustering (1)
- spatial orientation (1)
- spatial transformation (1)
- spatial updating (1)
- species delimitation (1)
- species distribution modelling (1)
- species persistence (1)
- species traits (1)
- species–area relationship (SAR) (1)
- spectral library (1)
- spectral matching (1)
- sperm morphometry (1)
- spermatogonia (1)
- spermidine (1)
- sphingolipid metabolism (1)
- sphingosine-1-phosphate (S1P) (1)
- sphingosine-1-phosphate receptors (1)
- spider behaviour (1)
- spider populations (1)
- spidergenitalia (1)
- spine surgery (1)
- spinnerets (1)
- spinning process (1)
- spirituality (1)
- spirocyclic piperidines (1)
- spleen (1)
- spleen volume (1)
- splenectomy (1)
- splenic rupture (1)
- spliceozyme (1)
- splicing (1)
- splicing regulation (1)
- splines (1)
- sports activity (1)
- spp. (1)
- spread (1)
- spring phenology (1)
- sputum (1)
- squid (1)
- ssp. (1)
- stable air (1)
- staff capacity (1)
- staff fluctuation (1)
- stand density (1)
- standard (1)
- standard fortification (1)
- standard mechanism (1)
- standard potential (1)
- standpoint theory (1)
- staphylococcal enterotoxin gene (1)
- staphylococcal enterotoxins (1)
- staphylococci (1)
- startle potentiation (1)
- starvation (1)
- statistical analysis (1)
- statistics & research methods (1)
- steered molecular dynamics (1)
- stellarator (1)
- stem bark (1)
- stem-like cells (1)
- stent (1)
- stereoscopy (1)
- stereoselectivity (1)
- stereotactic biopsy (1)
- stereotactic body radiation therapy (1)
- stereotypes (1)
- sternoclavicular joint dislocation (1)
- steroids (1)
- stochastic feedback (1)
- stochastisches Feedbacksignal (1)
- stoichiometry (1)
- stomas (1)
- stomatogastric ganglion (1)
- storage conditions (1)
- strategic management (1)
- stratigraphy (1)
- streptococci (1)
- stress memory (1)
- stress signal (1)
- stress ulcer (1)
- stress ulcer prophylaxis (1)
- stressors (1)
- stroke outcome (1)
- strong correlations (1)
- structural MRI (1)
- structural equation modeling (1)
- structural equation modelling (1)
- structural variants (1)
- structure-activity relationships (1)
- structure-function (1)
- structure-to-function relationship (1)
- structured illumination microscopy (1)
- structure–activity (1)
- students (1)
- study design (1)
- study of health in Pomerania (SHIP) (1)
- sturgeon (1)
- sub-ambient temperature (1)
- sub-inhibitory concentrations (1)
- sub-specialization (1)
- subacute (1)
- subbase-5 effect (1)
- subcellular fractionation (1)
- subcritical fluid chromatography (1)
- subgroup analysis (1)
- subjective cognitive decline (1)
- subjective health (1)
- submarine ground water discharge (1)
- submarine groundwater discharge (1)
- submerged vegetation (1)
- subsp. (1)
- subspecialization (1)
- substantive representation (1)
- substitution (1)
- substrates (1)
- sugar conformation (1)
- suicidal behavior (1)
- sulfate reducers (1)
- sulfonamide antibiotics (1)
- sulfonamides (1)
- sulfur-carrier protein (1)
- sumatriptan (1)
- summer skiing (1)
- sun (1)
- super-resolution microscopy (1)
- superantigen (1)
- supercapacitors (1)
- supercomplexes (1)
- superconductivity (1)
- supercritical CO<sub>2</sub> (1)
- supercritical fluid extraction (1)
- superior temporal sulcus (1)
- superresolution microscopy (1)
- supported lipid bilayers (1)
- surface (1)
- surface charge sensing (1)
- surface double layer (1)
- surface electrons (1)
- surface plasmon resonance (SPR) (1)
- surface proteins (1)
- surface samples (1)
- surface state (1)
- surgical (1)
- surgical patients (1)
- surgical procedures (1)
- surgically-induced immune dysfunction (1)
- surveillance (1)
- survey data (1)
- survey experiment (1)
- sustainability science (1)
- sustainable agriculture <i>Typha angustifolia</i> (1)
- sustainable aquaculture (1)
- sustainable consumption (1)
- sustainable development (1)
- sustainable developmental role (1)
- sustainable land use (1)
- sustainable policy performance (1)
- sustainable transformation (1)
- swarming (1)
- swelling (1)
- sylvatic anthrax (1)
- symptom burden (1)
- synaptic function (1)
- synaptic remodeling (1)
- synaptic transmission (1)
- synchrony (1)
- synchrotron radiation computed tomography (1)
- synergism (1)
- synthetic heparins (1)
- synthetic methods (1)
- system (1)
- systematics (1)
- systemic antibiotics (1)
- systemic inflammation (1)
- systems biology (1)
- tDCS (1)
- tPMP resistance (1)
- tRNA methyl transferase (1)
- tRNA modification (1)
- tVNS (1)
- talin (1)
- tandem PETases (1)
- tannins and flavonoids (1)
- tannins and flavonoids; anti-biofilm; E. coli; Epilobium; Filipendula; R. chamaemorus; biological activities; ethnobotany (1)
- tap water (1)
- tape stripping model (1)
- targeted chromosomal integration (1)
- targeted proteomics (1)
- task complexity (1)
- task dependency (1)
- task difficulty (1)
- tasks (1)
- teacher support (1)
- teachers as positive motivators (1)
- teacher–student relationship (1)
- teaching strategies (1)
- technical acceptance (1)
- teenagers (1)
- teeth (1)
- telediagnostic (1)
- telemetric capsules (1)
- telemetry (1)
- telephone consultation (1)
- telephone interview (1)
- teleradiology (1)
- telomerase (1)
- telomere (1)
- temperate forest (1)
- temperate trees (1)
- temperature adaptation (1)
- temperature limitation (1)
- template magnetic resonance images (1)
- temporal dynamics (1)
- temporal fitting (1)
- temporal instability (1)
- temporal pole (1)
- temporal variability (1)
- temporal voice area (1)
- temporary wetland (1)
- tensile studies (1)
- tephra layers (1)
- terahertz ellipsometry (1)
- terahertz emission spectroscopy (1)
- terahertz spintronics (1)
- terahertz time‐domain spectroscopy (1)
- terahertz transmission spectroscopy (1)
- terbinafine hydrochloride (1)
- test anxiety (1)
- test development (1)
- test equating (1)
- test standardization (1)
- tetra-nuclear nickel complex (1)
- text as data (1)
- texture analysis (1)
- texture-modified diet (1)
- thalamus (1)
- thatching companies (1)
- thematic analysis (1)
- theoretical description and modelling (1)
- theories of affective experience (1)
- therapeutics (1)
- thermal ablation (1)
- thermal melanisation (1)
- thermodilution (1)
- thermoregulation (1)
- thermosphere (1)
- thermotolerance (1)
- thickness loss (1)
- thin film deposition (1)
- thiocarboxylate (1)
- thioglucoside conjugates (1)
- thioureas (1)
- third molar (1)
- thoracic spine fracture (1)
- threaded cup (1)
- three-dimensional reconstruction (1)
- thrombin (1)
- thrombin inhibition (1)
- thrombo-inflammation (1)
- thromboembolism (1)
- thrusters (1)
- thumolycin (1)
- thyroid (1)
- thyroid auto-regulation (1)
- thyroid hormone (1)
- tick-borne fever (1)
- time restricted feeding (1)
- time-lagged (1)
- time-resolved optical emission spectroscopy (1)
- time-restricted feeding (1)
- timeliness (1)
- timing (1)
- tissue (1)
- tissue chemical composition (1)
- tissue specificity (1)
- titanium (Ti) alloys (1)
- titanium alloys (1)
- titanium surface modification (1)
- tobacco (1)
- toll-like receptors (1)
- tomato (1)
- tooth color (1)
- tooth eruption (1)
- tooth extraction (1)
- tooth survival (1)
- topological associating domains (1)
- topological quantum matter (1)
- topology (1)
- total hip arthroplasty (1)
- toxic shock syndrome (1)
- toxin A (1)
- toxin formation (1)
- toxin genes (1)
- toxins (1)
- trabectedin (1)
- trace amine-associated receptor 1 (1)
- trace data (1)
- track differences (1)
- tractography (1)
- trait anxiety (1)
- trajectories (1)
- trajectory (1)
- trajectory analysis (1)
- transaminase (1)
- transboundary river (1)
- transcranial direct current stimulation (1)
- transcript (1)
- transcript analyses (1)
- transcription start site (1)
- transcriptional factors (1)
- transcriptome analysis (1)
- transcriptome profile (1)
- transcutaneous vagus nerve stimulation (1)
- transesophageal echocardiography (1)
- transforming growth factor-β (1)
- transfusion (1)
- transgenic mouse model (1)
- transition (1)
- transition countries (1)
- transition transversion ratio (1)
- transitional waters (1)
- translational research (1)
- translocation (1)
- transmembrane domain (1)
- transmembrane pores (1)
- transport coefficients (1)
- transposable elements (1)
- transstadial persistence (1)
- treadmill (1)
- treadmill exercise (1)
- treatment (1)
- treatment control (1)
- treatment failure (1)
- treatment outcome (1)
- treatment planning (1)
- treatment tolerance (1)
- tree allometry (1)
- tree blossoms (1)
- tree growth (1)
- tree growth–climate correlation (1)
- tree harvesting losses (1)
- tree height (1)
- tree morphogy (1)
- tree ring (1)
- tree-growth (1)
- trees (1)
- tree‐ring network (1)
- tregs (1)
- trends (1)
- tri-block copolymer (1)
- trial (1)
- triamcinolone acetonide (1)
- trifunctionality (1)
- trinucleotide building block (1)
- tropical forest conversion (1)
- trospium (1)
- tryptophan (1)
- tryptophan metabolites (1)
- tubulin-based polymorphism (1)
- tumor (1)
- tumor biopsy (1)
- tumor immunology (1)
- tumor marker (1)
- tumor microbiome (1)
- tumor microenvironment (TME) (1)
- tumor spheroids (1)
- tumor suppressor (1)
- tumor-associated macrophages (1)
- tumour (1)
- tunicamycin (1)
- turbidites (1)
- two components systems (1)
- type 1 diabetes mellitus (1)
- type 2 immune response (1)
- type 2 immunity (1)
- type I IFN response (1)
- type I interferon (1)
- tyrosine ammonia lyase (1)
- ubiquitin-like protein (1)
- ubiquitination (1)
- ubiquitin–proteasome system (1)
- ubiquitin–proteasome system (UPS) (1)
- ultrafast spincaloritronics (1)
- ultrafast spintronics (1)
- ultramicrotomy (1)
- ulvan (1)
- uncertainty (1)
- uncertainty of measurement (1)
- underdetermination (1)
- undergraduate medical students (1)
- underprovision (1)
- unfolded and integrated stress response (1)
- universities (1)
- unmanned aerial vehicles (UAVs) (1)
- untargeted analysis (1)
- upcycling (1)
- upper limb motor function (1)
- upscaling (1)
- upstream-downstream conflict (1)
- urban avoiders (1)
- urban dwellers (1)
- urbanity indices (1)
- urbanization (1)
- urbanized coastal bay (1)
- urban–rural gradient (1)
- ureas (1)
- urinary exosomes (1)
- urine normalization (1)
- urine test strips (1)
- usability (1)
- user perspective (1)
- ustilagic acid (1)
- utility (1)
- utrophin (1)
- vaccination (1)
- vaccine-induced immune thrombotic thrombocytopenia (1)
- vaccines (1)
- validity (1)
- value chain (1)
- value chains (1)
- vapour pressure deficit (1)
- variable selection (1)
- variant of unknown clinical significance (1)
- variant of unknown significance (1)
- variants (1)
- varieties of capitalism (1)
- varves (1)
- vascular inflammation (1)
- vascular risk factors (1)
- vascular smooth muscle (1)
- vascularization (1)
- vegetation decomposition (1)
- vegetation relevés (1)
- venous disease (1)
- venous thromboembolism (1)
- ventilation (1)
- verbal creativity (1)
- vessel size imaging (1)
- veto player theory (1)
- viability (1)
- vincristine (1)
- violent acts (1)
- viral infections (1)
- viral load (1)
- virtual reality (1)
- virtual screening (1)
- virulence factor (1)
- virulence genes (1)
- virulence genes 3 (1)
- virulence regulation (1)
- virus (1)
- virus host interaction (1)
- virus infection (1)
- virus replication (1)
- virus-host interaction (1)
- viruses (1)
- vision loss (1)
- visual neuropils (1)
- visual processing (1)
- vitamin D3 (1)
- vitreous substitute (1)
- vocational education and training (1)
- voice (1)
- volatile organic compound (VOC) (1)
- volatile organic compounds (1)
- volatiles (1)
- volatility (1)
- volition (1)
- volumes (1)
- vomiting (1)
- von Willebrand factor (1)
- vorapaxar (1)
- vulnerable populations (1)
- wall index (1)
- warm pulses (1)
- warming rate (1)
- warning compliance (1)
- waste repositories (1)
- wastewater (1)
- water contact angle (1)
- water content (1)
- water deficit (1)
- water limitation (1)
- water table (1)
- waterlogging (1)
- water–rock interaction (1)
- weather (1)
- weather forecasting (1)
- weight gain (1)
- weight loss (1)
- weight regulation (1)
- wet forest (1)
- wet-warm (1)
- wetland (1)
- wetland buffer zones (1)
- wettability (1)
- wetting (1)
- wheeze (1)
- white matter (1)
- white matter hyperintensities (1)
- white matter hyperintensity (1)
- white matter integrity (1)
- white rhinos (1)
- white spot syndrome virus (1)
- white spruce (1)
- white-matter integrity (1)
- whole genome sequencing (1)
- whole-cell biocatalysis (1)
- whole-cellbiocatalysis (1)
- whole-exome sequencing (1)
- whole-genome sequencing (1)
- whole‐body imaging (1)
- wild birds (1)
- wild boar (1)
- wild ruminant (1)
- wildlife infectious diseases (1)
- wildling (1)
- wild‐type (1)
- willingness to sacrifice (1)
- wind energy (1)
- wind trajectory analysis (1)
- winter climate (1)
- winter ecology (1)
- within-population variation (1)
- women’s’ health (1)
- wood density (1)
- working environment (1)
- x-ray crystallography (1)
- yeast (1)
- yolk sac (1)
- young patients (1)
- zeta potential (1)
- zinc finger (1)
- zinc transport (1)
- zoonosis (1)
- (1)
- α-actinin-2 (1)
- α1-Adrenergic receptor (1)
- α‐hemolysin (1)
- β-amino acid (1)
- β-glucosidase (1)
- β-klotho (1)
- β-phenylalanine ethyl ester (1)
- γδ T cells (1)
- δ (1)
- σ (1)
- ω-hydroxy fatty acid (1)
- ω-transaminase (1)
- ‘Little Ice Age’ (LIA) (1)
- ‘Medical Informatics Initiative’ (1)
Institute
- Institut für Biochemie (121)
- Kliniken und Polikliniken für Innere Medizin (117)
- Institut für Physik (98)
- Institut für Community Medicine (95)
- Institut für Botanik und Landschaftsökologie & Botanischer Garten (92)
- Klinik und Poliklinik für Neurologie (89)
- Institut für Pharmazie (88)
- Institut für Psychologie (73)
- Zoologisches Institut und Museum (73)
- Institut für Geographie und Geologie (60)
- Abteilung für Mikrobiologie und Molekularbiologie (51)
- Institut für Pharmakologie (46)
- Klinik für Psychiatrie und Psychotherapie (44)
- Institut für Mikrobiologie - Abteilung für Genetik & Biochemie (43)
- Friedrich-Loeffler-Institut für Medizinische Mikrobiologie (37)
- Interfakultäres Institut für Genetik und Funktionelle Genomforschung (MNF) (36)
- Institut für Immunologie u. Transfusionsmedizin - Abteilung Immunologie (33)
- Institut für Diagnostische Radiologie und Neuroradiologie (32)
- Universitätsmedizin (32)
- Institut für Hygiene und Umweltmedizin (30)
- Institut für Mathematik und Informatik (30)
- Institut für Med. Biochemie u. Molekularbiologie (28)
- Klinik und Poliklinik für Kinder- und Jugendmedizin (28)
- Klinik und Poliklinik für Orthopädie und Orthopädische Chirurgie (25)
- Institut für Erziehungswissenschaft (22)
- Klinik und Poliklinik für Chirurgie Abt. für Unfall- und Wiederherstellungschirurgie (22)
- Klinik und Poliklinik für Chirurgie Abt. für Viszeral-, Thorax- und Gefäßchirurgie (22)
- Institut für Immunologie u. Transfusionsmedizin - Abteilung Transfusionsmedizin (21)
- Interfakultäres Institut für Genetik und Funktionelle Genomforschung (UMG) (21)
- Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie/Plastische Operationen (21)
- Poliklinik für Kieferorthopädie, Präventive Zahnmedizin und Kinderzahnheilkunde (21)
- Institut für Medizinische Psychologie (18)
- Zentrum für Zahn-, Mund- und Kieferheilkunde (18)
- Institut für Klinische Chemie und Laboratoriumsmedizin (17)
- Klinik und Poliklinik für Urologie (17)
- Institut für Pathologie (16)
- Institut für Politik- und Kommunikationswissenschaft (15)
- Klinik für Anästhesiologie und Intensivmedizin (14)
- Wirtschaftswissenschaften (14)
- Institut für Biometrie und Medizinische Informatik (13)
- Institut für Anatomie und Zellbiologie (12)
- Institut für Epidemiologie u. Sozialmedizin (12)
- Mathematisch-Naturwissenschaftliche Fakultät (12)
- Poliklinik für Zahnerhaltung, Parodontologie und Endodontologie (11)
- Klinik und Poliklinik für Neurochirurgie (10)
- Klinik und Poliklinik für Augenheilkunde (9)
- Klinik und Poliklinik für Frauenheilkunde u. Geburtshilfe (9)
- Klinik und Poliklinik für Innere Medizin Abt. Gastroenterologie, Endokrinologie und Ernährungsmedizin (9)
- Institut für Humangenetik (8)
- Klinik für Herz-, Thorax- und Gefäßchirurgie - Klinikum Karlsburg (7)
- Klinik und Poliklinik für Hautkrankheiten (6)
- Rechtswissenschaften (6)
- Klinik und Poliklinik für Hals-, Nasen-, Ohrenkrankheiten, Kopf- und Halschirurgie (5)
- Klinik und Poliklinik für Kinderchirurgie (5)
- Institut für Ethik und Geschichte der Medizin (4)
- Institut für Fennistik und Skandinavistik (4)
- Institut für Philosophie (4)
- Institut für Slawistik (4)
- Klinik und Poliklinik für Chirurgie (4)
- Rechts- und Staatswissenschaftliche Fakultät (4)
- Historisches Institut (3)
- Institut für Anglistik/Amerikanistik (3)
- Institut für Geologische Wissenschaften (3)
- Institut für Pathophysiologie (3)
- Klinik und Poliklinik für Innere Medizin Abt. Nephrologie, Hochdruckkrankheiten und Dialyse (3)
- Institut für Physiologie (2)
- Philosophische Fakultät (2)
- Theologie (2)
- Institut für Pflegewissenschaft und Interprofessionelles Lernen (1)
- Klinik und Poliklinik für Strahlentherapie (1)
- Poliklinik für zahnärztliche Prothetik und Werkstoffkunde (1)
Publisher
- MDPI (568)
- Frontiers Media S.A. (364)
- Wiley (223)
- S. Karger AG (156)
- Springer Nature (112)
- IOP Publishing (60)
- BioMed Central (BMC) (59)
- SAGE Publications (50)
- Nature Publishing Group (39)
- Copernicus (20)
Copper tungsten oxide films are deposited with the help of reactive high power impulse magnetron sputtering (HiPIMS) in an argon/oxygen gas mixture. Two magnetrons, one equipped with a tungsten target and the other with a copper target, are employed. The HiPIMS discharge is operated with a repetition frequency of f=100 Hz. Pulse widths of 100 and 20 µs separated by 25 µs are chosen for the tungsten and copper target, respectively. Films deposited on two different glass substrates [soda lime glass and fluorine doped tin oxide (FTO) coated glass] are characterized by energy dispersive x-ray spectroscopy, x-ray photoelectron spectroscopy, x-ray diffraction, Raman spectroscopy, and ellipsometry. Photoelectrochemical activity was investigated by linear voltammetry. The composition and crystal structure of as-deposited and annealed films are found to depend on the deposition conditions. Annealed films deposited on FTO glass are composed of WO3 and CuWO4 or Cu2WO4 crystal phases. Films deposited on soda lime glass are subject to sodium diffusion into the films during annealing and the formation of Na2W2O7 and Na2W4O13 phases.
This article sheds light on the obstacles that women face as members of the government by answering the questions: How does the sex of ministers shape the way MPs’ assess the quality of their work? And, how does this relationship differ depending on the political ideology of MPs? We argue that legislators assess the competencies of women ministers differently after the activation of gender stereotypes, but that the way they react depends on the ideological orientation of their party. We investigate this topic in a real-word context using a unique survey experiment with German and Austrian MPs. The evidence reveals that, while MPs belonging to right-wing parties perceive women in the executive as less competent than men ministers, their colleagues from left-wing parties actually assess them more favorably. These findings highlight the persistence of old myths about women’s lacking political skills and the emergence of new ones about women’s superior ability to govern.
Introduction: Adiposity and excessive weight are on the rise in western industrialized countries. In cases where conservative measures fail and surgical interventions are not (yet) desired, gastric balloon therapy has proven to be a safe and reversible endoscopic method. Methods: Aside from weight progression under gastric balloon therapy and by using MRI, our research paper describes the behavior of different abdominal body fat compartments at the beginning and at the end of the gastric balloon therapy. Additionally, the volume of the left liver lobe as well as the fill volume and performance of the gastric balloon were analyzed over the duration of treatment. For assessing potential impacts of weight reduction on the muscle mass, we determined the area of the m. psoas on a comparable cross-sectional area at the beginning and at the end of the therapy. Results: We were able to verify a significant reduction of the layer of subcutaneous fat, adipose capsule of the kidney, and intra-abdominal fatty tissue during the therapy. The volume of the left liver lobe was shrinking in addition to a muscle loss during the balloon therapy. The volume of the gastric balloon remained stable (not hyperinflation). There were variable gas bubbles in the gastric balloon. Conclusion: The gastric balloon is a temporary and successful option for weight reduction by reducing body fat, liver volume, but also muscle mass.
Purpose
The German Retina.net ROP registry and its Europe-wide successor, the EU-ROP registry, collect data from patients treated for ROP. This analysis compares input parameters of these two registries to establish a procedure for joint analyses of different registry data using exemplary datasets from the two registries.
Methods
Exemplary datasets from the two databases over a 1-year period each (German Retina.net ROP Registry, 2011, 22 infants; EU-ROP Registry, 2021, 44 infants) were compared. The parameters documented in the two databases were aligned and analysed regarding demographic parameters, treatment modalities, complications within first 24 h and retreatments.
Results
The current analysis showed that data can be aligned for joint analyses with some adjustments within the data structure. The registry with more detailed data collection (EU-ROP) needs to be reduced regarding granularity in order to align the different registries, as the registry with lower granularity determines the level of analyses that can be performed in a comparative approach. In the exemplary datasets, we observed that the overall most common ROP severity in both registries was zone II, 3+ (2011: 70.5%; 2021: 65%), with decreasing numbers of clock hours showing preretinal neovascularisations (2011: 10–12 clock hours in 29% of cases, 2021: 4–6 clock hours in 38%). The most prevalent treatment method was laser coagulation in 2011 (75%) and anti-VEGF therapy in 2021 (86.1%). Within the anti-VEGF group, all patients were treated with bevacizumab in 2011 and with ranibizumab in 2021. Retreatment rates were comparable in 2011 and 2021.
Conclusion
Data from two different ROP registries can be aligned and jointly analysed. The analysis reveals a paradigm shift in treatment modalities, from predominantly laser to anti-VEGF, and within the anti-VEGF group from bevacizumab to ranibizumab in Germany. In addition, there was a trend towards earlier treatment in 2021.
Hibernation is a widespread adaptation in animals to seasonally changing environmental conditions. In the face of global anthropogenic change, information about plastic adjustments to environmental conditions and associated mortality costs are urgently needed to assess population persistence of hibernating species. Here, we used a five-year data set of 1047 RFID-tagged individuals from two bat species, Myotis nattereri and Myotis daubentonii that were automatically recorded each time they entered or left a hibernaculum. Because the two species differ in foraging strategy and activity pattern during winter, we expected species–specific responses in the timing of hibernation relative to environmental conditions, as well as different mortality costs of early departure from the hibernaculum in spring. Applying mixed-effects modelling, we disentangled population-level and individual-level plasticity in the timing of departure. To estimate mortality costs of early departure, we used both a capture mark recapture analysis and a novel approach that takes into account individual exposure times to mortality outside the hibernaculum. We found that the timing of departure varied between species as well as among and within individuals, and was plastically adjusted to large-scale weather conditions as measured by the NAO (North Atlantic Oscillation) index. Individuals of M. nattereri, which can exploit milder temperatures for foraging during winter, tuned departure more closely to the NAO index than individuals of M. daubentonii, which do not hunt during winter. Both analytical approaches used to estimate mortality costs showed that early departing individuals were less likely to survive until the subsequent hibernation period than individuals that departed later. Overall, our study demonstrates that individuals of long-lived hibernating bat species have the potential to plastically adjust to changing climatic conditions, although the potential for adjustment differs between species.
We apply the charge simulation method (CSM) in order to compute the logarithmic capacity of compact sets consisting of (infinitely) many “small” components. This application allows to use just a single charge point for each component. The resulting method therefore is significantly more efficient than methods based on discretizations of the boundaries (for example, our own method presented in Liesen et al. (Comput. Methods Funct. Theory 17, 689–713, 2017)), while maintaining a very high level of accuracy. We study properties of the linear algebraic systems that arise in the CSM, and show how these systems can be solved efficiently using preconditioned iterative methods, where the matrix-vector products are computed using the fast multipole method. We illustrate the use of the method on generalized Cantor sets and the Cantor dust.
Representative epidemiologic data on the average volume of the parotid gland in a large population-based MRI survey is non-existent. Within the Study of Health in Pomerania (SHIP), we examined the parotid gland in 1725 non-contrast MRI-scans in T1 weighted sequence of axial layers. Thus, a reliable standard operating procedure (Intraclass Correlation Coefficient > 0.8) could be established. In this study, we found an average, single sided parotid gland volume of 27.82 cm3 (95% confidence interval (CI) 27.15 to 28.50) in male and 21.60 cm3 (95% CI 21.16 to 22.05) in female subjects. We observed positive associations for age, body mass index (BMI), as well as male sex with parotid gland size in a multivariate model. The prevalence of incidental tumors within the parotid gland regardless of dignity was 3.94% in the Northeast German population, slightly higher than assumed. Further epidemiologic investigations regarding primary salivary gland diseases are necessary.
Hematophagous leeches express a broad variety of secretory factors in their salivary glands; among them are hirudins, inhibitors of blood coagulation, and decorsins/ornatins, inhibitors of platelet aggregation. Here, we describe the identification and molecular and functional characterization of putative hirudins and decorsins/ornatins in two leech species of American origin, Limnobdella mexicana and Haementeria vizottoi. The leech species represent two orders of leeches, the proboscis-bearing Rhynchobdellida and the non-proboscis-bearing Arhynchobdellida. Members of the hirudin superfamily, such as hirudins or decorsins/ornatins, are described for the first time in the genus Haementeria. Both species expressed very potent inhibitors of platelet aggregation, but only the putative hirudins of L. mexicana displayed high thrombin-inhibitory potency, whereas the putative hirudin of H. vizottoi turned out to be a hirudin-like factor. The results of our study provide new insights into the evolutionary background of the blood-sucking lifestyle in leeches.
Although the common pathology of Alzheimer’s disease (AD) and white matter hyperintensities (WMH) is disputed, the gene TREML2 has been implicated in both conditions: its whole-blood gene expression was associated with WMH volume and its missense variant rs3747742 with AD risk. We re-examined those associations within one comprehensive dataset of the general population, additionally searched for cross-relations and illuminated the role of the apolipoprotein E (APOE) ε4 status in the associations. For our linear regression and linear mixed effect models, we used 1949 participants from the Study of Health in Pomerania (Germany). AD was assessed using a continuous pre-symptomatic MRI-based score evaluating a participant’s AD-related brain atrophy. In our study, increased whole-blood TREML2 gene expression was significantly associated with reduced WMH volume but not with the AD score. Conversely, rs3747742-C was significantly associated with a reduced AD score but not with WMH volume. The APOE status did not influence the associations. In sum, TREML2 robustly associated with WMH volume and AD-related brain atrophy on different molecular levels. Our results thus underpin TREML2’s role in neurodegeneration, might point to its involvement in AD and WMH via different biological mechanisms, and highlight TREML2 as a worthwhile target for disentangling the two pathologies.
The predominantly vegetative propagating duckweeds are of growing commercial interest. Since clonal accessions within a respective species can vary considerably with respect to their physiological as well as biochemical traits, it is critical to be able to track the clones of species of interest after their characterization. Here, we compared the efficacy of five different genotyping methods for Spirodela polyrhiza, a species with very low intraspecific sequence variations, including polymorphic NB-ARC-related loci, tubulin-gene-based polymorphism (TBP), simple sequence repeat variations (SSR), multiplexed ISSR genotyping by sequencing (MIG-seq), and low-coverage, reduced-representation genome sequencing (GBS). Four of the five approaches could distinguish 20 to 22 genotypes out of the 23 investigated clones, while TBP resolved just seven genotypes. The choice for a particular method for intraspecific genotyping can depend on the research question and the project budget, while the combination of orthogonal methods may increase the confidence and resolution for the results obtained.
Target Mechanisms of the Cyanotoxin Cylindrospermopsin in Immortalized Human Airway Epithelial Cells
(2022)
Cylindrospermopsin (CYN) is a cyanobacterial toxin that occurs in aquatic environments worldwide. It is known for its delayed effects in animals and humans such as inhibition of protein synthesis or genotoxicity. The molecular targets and the cell physiological mechanisms of CYN, however, are not well studied. As inhalation of CYN-containing aerosols has been identified as a relevant route of CYN uptake, we analyzed the effects of CYN on protein expression in cultures of immortalized human bronchial epithelial cells (16HBE14o−) using a proteomic approach. Proteins whose expression levels were affected by CYN belonged to several functional clusters, mainly regulation of protein stability, cellular adhesion and integration in the extracellular matrix, cell proliferation, cell cycle regulation, and completion of cytokinesis. With a few exceptions of upregulated proteins (e.g., ITI inhibitor of serine endopeptidases and mRNA stabilizer PABPC1), CYN mediated the downregulation of many proteins. Among these, centrosomal protein 55 (CEP55) and osteonectin (SPARC) were significantly reduced in their abundance. Results of the detailed semi-quantitative Western blot analyses of SPARC, claudin-6, and CEP55 supported the findings from the proteomic study that epithelial cell adhesion, attenuation of cell proliferation, delayed completion of mitosis, as well as induction of genomic instability are major effects of CYN in eukaryotic cells.
Background: Little is known about how substance use affects health-related quality of life (HRQOL) in depressed individuals. Here, associations between alcohol consumption and HRQOL in hospital and ambulatory care patients with past-year depressive symptoms are analyzed. Method: The sample consisted of 590 participants (26.8% non-drinkers) recruited via consecutive screenings. Individuals with alcohol use disorders were excluded. HRQOL was assessed with the Veterans Rand 12-item health survey (VR-12). Multivariable fractional polynomials (MFP) regression analyses were conducted (1) to test for non-linear associations between average daily consumption and HRQOL and (2) to analyze associations between alcohol consumption and the physical and mental health component summaries of the VR-12 and their subdomains. Results: Alcohol consumption was positively associated with the physical health component summary of the VR-12 (p = 0.001) and its subdomains general health (p = 0.006), physical functioning (p < 0.001), and bodily pain (p = 0.017), but not with the mental health component summary (p = 0.941) or any of its subdomains. Average daily alcohol consumption was not associated with HRQOL. Conclusion: Alcohol consumption was associated with better physical HRQOL. Findings do not justify ascribing alcohol positive effects on HRQOL. Data indicate that non-drinkers may suffer from serious health disorders. The results of this study can inform the development of future alcohol- and depression-related interventions.
Simple Summary
The treatment of high-risk neuroblastoma patients with anti-GD2 antibodies has improved survival, and it is an established treatment strategy; however, many patients still experience a late relapse. One disadvantage of passive immunotherapy is the absence of a memory response. Therefore, developing an active immunotherapy leading to a sustained immune response may provide a solution and prevent the occurrence of late relapses following anti-GD2 antibody therapy. Here, we describe the first-in-man compassionate use of the ganglidiomab vaccine following passive immunotherapy with an anti-GD2 antibody (dinutuximab beta) in seven neuroblastoma patients. The vaccine was well-tolerated, and all patients not pre-treated by haploidentical transplantation developed vaccine-specific immune responses.
Abstract
(1) Background: High-risk neuroblastoma (HR-NB) is associated with a poor prognosis despite a multimodal high-intensity treatment regimen, including immunotherapy with anti-GD2 monoclonal antibodies (mAb). Here, we investigated the effects of an anti-idiotypic vaccine based on the mAb ganglidiomab that structurally mimics GD2. (2) Methods: Patients with HR-NB treated with anti-GD2 mAb dinutuximab beta and who achieved complete remission after frontline or salvage therapy were offered the vaccine (0.5 mg ganglidiomab adsorbed to Alhydrogel®). Side effects (CTCAE v4.03) and immune responses were determined on each visit. We also evaluated the time to relapse or progression until the last follow-up. (3) Results: Seven HR-NB patients (five frontlines, two relapsed) received 6–22 subcutaneous injections every two weeks. Six of the seven patients showed an immune response. The non-responding patient had a haploidentical stem cell transplantation as part of the previous treatment. No fever, pain, neuropathy, or toxicities ≥ grade 3 occurred during or post-treatment. All immunized patients did not experience relapses or progressions of their neuroblastoma. (4) Conclusions: This is the first-in-man use of the ganglidiomab vaccine, which was well-tolerated, and all patients not pre-treated by haploidentical transplantation developed vaccine-specific immune responses. These findings provide an important basis for the design of prospective clinical trials.
Eicosanoids are lipid mediators generated from arachidonic acid with pro- and anti-inflammatory properties. Despite these lipid mediators being known for decades, quantitative determination in biological samples is still challenging due to low abundance, instability, the existence of regio- and stereoisomers, and a wide polarity range that hampers chromatographic separation. In this study, we developed a supercritical fluid chromatography mass spectrometry (SFC-MS) platform for the quantification of relevant eicosanoids. Application of a chiral amylose-based column and modifier combination of 2-propanol/acetonitrile offered separation and sufficient resolution of 11 eicosanoids (5-, 12-, 15-HETE, PGB1, LTB4, t-LTB4, 20-OH-LTB4, PGE2, PGD2, PGF2α, TxB2) with baseline separation of isobaric analytes within 12 min. The method was validated in terms of range (78–2500 ng/mL), linearity, accuracy, precision, and recovery according to EMA guidelines. Finally, we confirmed the method’s applicability by quantifying eicosanoid levels in human primary blood cells. In conclusion, we present a validated SFC-MS method for the determination of relevant eicosanoids in biological samples with a wide range of polarity while maintaining baseline separation of isobars, which allows coupling to a single quadrupole mass detector.
A New Laboratory Workflow Integrating the Free Light Chains Kappa Quotient into Routine CSF Analysis
(2022)
We performed this cohort study to test whether further analysis of intrathecal inflammation can be omitted if the free light chain kappa (FLCκ) quotient is within the reference range in the corresponding quotient diagram. FLCκ concentrations were measured in serum and cerebrospinal fluid (CSF) samples. The intrathecal fraction (IF) of FLCκ was calculated in relation to the hyperbolic reference range. 679 patient samples were used as a discovery cohort (DC). The sensitivity and negative predictive value (NPV) of the FLCκ-IF for the detection of an intrathecal humoral immune response (CSF-specific OCB and/or IF IgG/A/M > 0%) was determined. Based on these data, a diagnostic algorithm was developed and prospectively validated in an independent validation cohort (VC, n = 278). The sensitivity of the FLCκ-IF was 98% in the DC and 97% in the VC with a corresponding NPV of 99%. The use of the FLCκ-IF as a first line analysis would have reduced the Ig and OCB analysis by 62% in the DC and 74% in the VC. The absence of a FLCκ-IF predicts the absence of a humoral intrathecal immune response with a very high NPV of 99%. Thus, integration of our proposed algorithm into routine CSF laboratory analysis could help to reduce analytical efforts.
Amine transaminases (ATAs) are powerful biocatalysts for the stereoselective synthesis of chiral amines. However, wild-type ATAs usually show pH optima at slightly alkaline values and exhibit low catalytic activity under physiological conditions. For efficient asymmetric synthesis ATAs are commonly used in combination with lactate dehydrogenase (LDH, optimal pH: 7.5) and glucose dehydrogenase (GDH, optimal pH: 7.75) to shift the equilibrium towards the synthesis of the target chiral amine and hence their pH optima should fit to each other. Based on a protein structure alignment, variants of (R)-selective transaminases were rationally designed, produced in E. coli, purified and subjected to biochemical characterization. This resulted in the discovery of the variant E49Q of the ATA from Aspergillus fumigatus, for which the pH optimum was successfully shifted from pH 8.5 to 7.5 and this variant furthermore had a two times higher specific activity than the wild-type protein at pH 7.5. A possible mechanism for this shift of the optimal pH is proposed. Asymmetric synthesis of (R)-1-phenylethylamine from acetophenone in combination with LDH and GDH confirmed that the variant E49Q shows superior performance at pH 7.5 compared to the wild-type enzyme.
Background: Colorectal carcinoma (CRC) is a heterogeneous disease, and differences in outcomes have been reported among patients diagnosed with the same disease stage. Prognostic and predictive biomarkers provide information for patient risk stratification and guide treatment selection. Although numerous studies have analyzed the effects of systemic inflammatory factors on CRC outcomes, clinical significance remains to be elucidated. In particular, the treatment strategy of colon cancer patients is different from that of rectal cancer due to outcome and recurrence differences. The identification of patients with a poor prognosis who might benefit from intensive treatment approaches is clinically necessary. Methods: This study aimed to evaluate the value of different blood-based markers and assess the significance of our newly developed inflammatory-nutrition-related biomarker (NCR = BMI × albumin/CRP) in patients with colon cancer. A two-stage design was used with 212 patients with colon cancer (CC) in the discovery cohort (n = 159) and in an external validation cohort (n = 53). Results: A lower preoperative NCR level was significantly correlated with a worse prognosis, sidedness, undifferentiated histology, nodal involvement, and advanced UICC stage. We compared the NCR with other established prognostic indices and showed that the NCR is a more reliable indicator of a poor prognosis for patients with CC. Patients with low NCR levels experienced a significantly shorter Overall Survival (OS) than patients with high levels. Multivariate analysis confirmed preoperative NCR levels as an independent predictor for overall survival with a hazard ratio of 3.3 (95% confidence interval 1.628–6.709, p < 0.001). Finally, we confirmed the predictive value of the NCR in an independent validation cohort and confirmed NCR as an independent prognostic factor for OS. Conclusion: Taken together, we discovered a new prognostic index (NCR) based on BMI, albumin, and CRP levels as an independent prognostic predictor of OS in patients with colon cancer. In all UICC stages, our newly developed NCR marker is able to distinguish patients with better and worse prognoses. We, therefore, propose that NCR may serve as a supplement to the TNM staging system to optimize the risk stratification in CC patients towards personalized oncology. In particular, NCR can be used in clinical trials to stratify patients with UICC II and III tumors and help better select patients who might benefit from adjuvant treatment.
Background
Neuroinflammation and maladaptive neuroplasticity play pivotal roles in migraine (MIG), trigeminal autonomic cephalalgias (TAC), and complex regional pain syndrome (CRPS). Notably, CRPS shares connections with calcitonin gene-related peptide (CGRP) in its pathophysiology. This study aims to assess if the documented links between CRPS and MIG/TAC in literature align with clinical phenotypes and disease progressions. This assessment may bolster the hypothesis of shared pathophysiological mechanisms.
Methods
Patients with CRPS (n = 184) and an age-/gender-matched control group with trauma but without CRPS (n = 148) participated in this case–control study. Participant answered well-established questionnaires for the definition of CRPS symptoms, any headache complaints, headache entity, and clinical management.
Results
Patients with CRPS were significantly more likely to suffer from migraine (OR: 3.23, 95% CI 1.82–5.85), TAC (OR: 8.07, 95% CI 1.33–154.79), or non-classified headaches (OR: 3.68, 95% CI 1.88–7.49) compared to the control group. Patients with MIG/TAC developed CRPS earlier in life (37.2 ± 11.1 vs 46.8 ± 13.5 years), had more often a central CRPS phenotype (60.6% vs. 37.0% overall) and were three times more likely to report allodynia compared to CRPS patients with other types of headaches. Additionally, these patients experienced higher pain levels and more severe CRPS, which intensified with an increasing number of headache days. Patients receiving monoclonal antibody treatment targeting the CGRP pathway for headaches reported positive effects on CRPS symptoms.
Conclusion
This study identified clinically relevant associations of MIG/TAC and CRPS not explained by chance. Further longitudinal investigations exploring potentially mutual pathomechanisms may improve the clinical management of both CRPS and primary headache disorders.
Trial registration
German Clinical Trials Register (DRKS00022961).
Perception of climate change-related forest dieback in mountain forests among the local population
(2023)
Mountain forests provide multiple benefits but are threatened by climate change-induced forest dieback. Although many studies summarize perceptions of forest ecosystem services, relatively few deal with mountain forests. The local population’s perception of forest dieback in mountain forests in relation to climate change has rarely been investigated so far. Their perspective is relevant as local people are often deeply attached to “their” forests, they actively use forest ecosystems and—as voters and taxpayers—they need to support the state’s adaptation and funding measures. Therefore, this study investigates the climate change and forest dieback perception of local inhabitants in two mountain areas of Southern Germany (the German Alps and the Bavarian Forest) with a quantitative survey based on representative online samples (n = 709). Relying conceptually on van der Linden’s (J Environ Psychol 41:112–124, 2015. https://doi.org/10.1016/j.jenvp.2014.11.012) climate change risk perception model, the results show that experiential processing, cognitive and socio-cultural factors are related to locals’ forest dieback and climate change perception, while socio-demographics show no or few connections. Nearly two-thirds (64.7%) of the respondents perceive moderate to strong forest dieback, while more than half (55.0%) of the respondents already observe consequences of climate change. The perceptions of climate change and forest dieback are positively correlated with medium to high strength. This shows that forest dieback could be interpreted as an indicator of climate change, which is difficult to observe due to its long-term nature. We identify three groups of respondents regarding preferred forest adaptation strategies to climate change. In general, respondents support nature-based forest adaptation strategies over intense measures.
Toarciconiopteryx dipterosimilis gen. et sp. nov. is described from the Lower Toarcian of Grimmen (Western Pomerania, Germany) based on a hind wing. This enigmatic wing superficially resembles a dipteran forewing, but analysis in detail establishes that it belongs to the Neuroptera. We assign it to the Coniopterygidae with great confidence by its great concordance with the hind wings of that family, but a small possibility remains that it might belong to the Dipteromantispidae, although the very derived haltere-like hind wings of all its known members are entirely unlike it. We, therefore, consider it to be the oldest record of Coniopterygidae. We create the new subfamily Toarciconiopteryginae subfam. nov. for it, which is distinguished from other Coniopterygidae by its hind wings possessing two branches of RP and a proximal forking of M. These conditions are also known in some Sialidae (Megaloptera), supporting the hypothesis that Coniopterygidae is the sister group of all other Neuroptera, as Megaloptera is considered by most authors to be sister to Neuroptera. New interpretations of some aspects of the Coniopterygidae venation are proposed.
Seventeen bacterial strains able to suppress plant pathogens have been isolated from healthy Vietnamese crop plants and taxonomically assigned as members of the Bacillus cereus group. In order to prove their potential as biocontrol agents, we perform a comprehensive analysis that included the whole-genome sequencing of selected strains and the mining for genes and gene clusters involved in the synthesis of endo- and exotoxins and secondary metabolites, such as antimicrobial peptides (AMPs). Kurstakin, thumolycin, and other AMPs were detected and characterized by different mass spectrometric methods, such as MALDI-TOF-MS and LIFT-MALDI-TOF/TOF fragment analysis. Based on their whole-genome sequences, the plant-associated isolates were assigned to the following species and subspecies: B. cereus subsp. cereus (6), B. cereus subsp. bombysepticus (5), Bacillus tropicus (2), and Bacillus pacificus. These three isolates represent novel genomospecies. Genes encoding entomopathogenic crystal and vegetative proteins were detected in B. cereus subsp. bombysepticus TK1. The in vitro assays revealed that many plant-associated isolates enhanced plant growth and suppressed plant pathogens. Our findings indicate that the plant-associated representatives of the B. cereus group are a rich source of putative antimicrobial compounds with potential in sustainable agriculture. However, the presence of virulence genes might restrict their application as biologicals in agriculture.
Peatlands contribute to a wide range of ecosystem services. They play an important role as carbon sinks in their natural state, but when they are drained, they cause carbon emissions. Rewetting drained peatlands is required to reduce carbon emissions and create new carbon sinks. However, drained peatlands are commonly used as grassland or croplands; therefore, alternative agriculture schemes are required following rewetting. Paludiculture, i.e., agriculture on wet and rewetted peatlands, is an option in these areas after rewetting to produce biomass sustainably. Monitoring of peatland management is challenging, yet needed to ensure a successful rewetting and plantation of, e.g., Phragmites australis and Typha spp., two plants which are commonly used in paludiculture. Remote sensing is an excellent tool for monitoring the vegetation composition of vast rewetted peatland regions. However, because many peatland species have similar spectral characteristics, such monitoring is ideally based on high-spatial, high-temporal hyperspectral images. Data that complies with all these requirements does not exist on a regular basis. Therefore, we assessed the potential for mapping peatland vegetation communities in the Peene and Trebel river basins of the federal state of Mecklenburg-Western Pomerania, Germany, using multi-date hyperspectral (PRISMA) data. We used regression-based unmixing to map fractions of different peatland vegetation classes. Results were analyzed with regard to the contribution of multi-date observations and, in comparison, to multispectral datasets (Landsat-8/Sentinel-2). Our results showed that different classes are best mapped at different observation dates. The multi-date hyperspectral datasets produced less Mean Absolute Error (MAE = 16.4%) than the single-date hyperspectral images (ΔMAE + 1%), with high accuracies for all classes of interest. Compared to the results obtained with multispectral data from similar acquisition dates and annual spectral-temporal metrics (STM), the results from hyperspectral data were always clearly superior (ΔMAE + 4%). Besides the superior performance during comparisons, our results also indicate that information that can be derived from the hyperspectral data with the regression-based unmixing goes clearly beyond that of discrete classification. With more hyperspectral sensors coming up and an expected higher availability of multi-data hyperspectral imagery, these data can be expected to play a bigger role in the future monitoring of peatlands.
The male genitalia of pholcid spiders, which is one of the most species-rich spider families, are characterized by a procursus, which is a morphologically diverse projection of the copulatory organ. It has been shown that the procursus interacts with the female genitalia during copulation. Here, we investigate the function of the procursus in Gertschiola neuquena, a species belonging to the early branched and understudied subfamily Ninetinae, using behavioural and morphological data. Although many aspects of the copulatory behaviour of G. neuquena follow the general pattern described for the family, males use only one pedipalp during each copulation. Based on our micro-CT analysis of cryofixed mating pairs using virgin females, we can show that the long and filiform procursus is inserted deeply into the unpaired convoluted female spermatheca, and the intromittent sclerite, the embolus, is rather short and stout only reaching the most distal part of the female sperm storage organ. Histological data revealed that sperm are present in the most proximal part of the spermatheca, suggesting that the procursus is used to allocate sperm deeply into the female sperm storage organ. This represents the first case of a replacement of the sperm allocation function of the intromittent sclerite in spiders.
Background
The alignment of large numbers of protein sequences is a challenging task and its importance grows rapidly along with the size of biological datasets. State-of-the-art algorithms have a tendency to produce less accurate alignments with an increasing number of sequences. This is a fundamental problem since many downstream tasks rely on accurate alignments.
Results
We present learnMSA, a novel statistical learning approach of profile hidden Markov models (pHMMs) based on batch gradient descent. Fundamentally different from popular aligners, we fit a custom recurrent neural network architecture for (p)HMMs to potentially millions of sequences with respect to a maximum a posteriori objective and decode an alignment. We rely on automatic differentiation of the log-likelihood, and thus, our approach is different from existing HMM training algorithms like Baum–Welch. Our method does not involve progressive, regressive, or divide-and-conquer heuristics. We use uniform batch sampling to adapt to large datasets in linear time without the requirement of a tree. When tested on ultra-large protein families with up to 3.5 million sequences, learnMSA is both more accurate and faster than state-of-the-art tools. On the established benchmarks HomFam and BaliFam with smaller sequence sets, it matches state-of-the-art performance. All experiments were done on a standard workstation with a GPU.
Conclusions
Our results show that learnMSA does not share the counterintuitive drawback of many popular heuristic aligners, which can substantially lose accuracy when many additional homologs are input. LearnMSA is a future-proof framework for large alignments with many opportunities for further improvements.
The multi-cell Penning–Malmberg trap concept has been proposed as a way to accumulate and confine unprecedented numbers of antiparticles, an attractive but challenging goal. We report on the commissioning and first results (using electron plasmas) of the World's second prototype of such a trap, which builds and improves on the findings of its predecessor. Reliable alignment of both ‘master’ and ‘storage’ cells with the axial magnetic field has enabled confinement of plasmas, without use of the ‘rotating wall’ (RW) compression technique, for over an hour in the master cell and tens of seconds in the storage cells. In the master cell, attachment to background neutrals is found to be the main source of charge loss, with an overall charge-confinement time of 8.6 h. Transfer to on-axis and off-axis storage cells has been demonstrated, with an off-axis transfer rate of 50% of the initial particles, and confinement times in the storage cells in the tens of seconds (again, without RW compression). This, in turn, has enabled the first simultaneous plasma confinement in two off-axis cells, a milestone for the multi-cell trap concept.
The controlled formation and adjustment of size and density of magnetic skyrmions in Ta/CoFeB/MgO trilayers with low Dzyaloshinskii–Moriya interaction is demonstrated. Close to the out-of-plane to in-plane magnetic spin reorientation transition, we find that small energy contributions enable skyrmion formation in a narrow window of 20 pm in CoFeB thickness. Zero-field stable skyrmions are established with proper magnetic field initialization within a 10 pm CoFeB thickness range. Using magneto-optical imaging with quantitative image processing, variations in skyrmion distribution and diameter are analyzed quantitatively, the latter for sizes well below the optical resolution limit. We demonstrate the controlled merging of individual skyrmions. The overall demonstrated degree of comprehension of skyrmion control aids to the development of envisioned skyrmion based magnetic memory devices.
Minced Cartilage Implantation in Acetabular Cartilage Defects: Case Series with 2-Year Results
(2023)
Objective
The objective was to evaluate clinical outcome and safety of arthroscopic, autologous minced cartilage implantation for acetabular cartilage lesions observed during hip arthroscopy to treat femoroacetabular impingement syndrome (FAIS).
Design
Eleven male patients, average age: 29.4 ± 5.4 years, average body mass index (BMI): 24.2 ± 2.2 kg/m2, scheduled for hip arthroscopy due to FAIS accompanied by an acetabular cartilage lesion were included in the case series. Cartilage tissue was harvested and minced from the loose cartilage flap at the chondrolabral lesion by arthroscopic shaver, augmented with autologous conditioned plasma, implanted into the defect, and fixated by autologous thrombin. Concomitant interventions were performed as indicated. The patients were evaluated preoperatively and at 24-month follow-up, using the International Hip Outcome Tool-12 (iHOT-12) and Visual Analog Scale (VAS) pain score and by magnetic resonance imaging (MRI) using the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) grading scale at the 2-year follow-up.
Results
The defect size was on average 3.5 cm2 (1.5-4.5 cm2). From preoperatively to 2 years postoperatively, the iHOT-12 significantly improved from 50.2 ± 18 to 86.5 ± 19 (P < 0.0001), and pain score decreased from 5.6 ± 1.8 to 1.0 ± 1.5 (P < 0.0001) on the Visual Analog Scale pain score. Regarding functional outcome and pain, 10 of the 11 patients and all patients reached the minimal clinically important difference (MCID), respectively. The postoperative average MOCART score was 87.2 (± 9.2). No adverse events or reoperations were observed.
Conclusions
Arthroscopic, autologous minced cartilage implantation for treating full-thickness acetabular cartilage lesions in FAIS shows statistically and clinically significant improvement at short-term follow-up.
Background:
Minced cartilage implantation (MCI) has seen a renaissance in recent years. In this evolved technique, human articular cartilage is harvested with an arthroscopic shaver, augmented with platelet-rich plasma (PRP), and implanted with autologous thrombin. This modified technique combines the possibility of cell-based surgical cartilage repair with a minimally invasive autologous 1-step procedure. However, evidence on cell survival and preserved function after shaver-based mincing and PRP supplementation is limited.
Purpose:
To evaluate the effects of arthroscopic shaver mincing and augmentation with PRP on human cartilage tissue.
Study Design:
Controlled laboratory study.
Methods:
Standardized samples were taken from 12 donors during autologous MCI. A comparison of cell outgrowth, cell viability, proliferation capacity, and ability to produce extracellular matrix–specific proteoglycans after chondrogenic redifferentiation was made between cartilage taken by curettage from the border of the cartilage defect, cartilage tissue minced by an arthroscopic shaver, and cartilage tissue minced by an arthroscopic shaver that was additionally augmented with autologous PRP.
Results:
There was no difference between all 3 groups in terms of cell outgrowth or proliferation capacity. Metabolic activity relative to the cell number of chondrocytes isolated from shaver-minced cartilage was higher compared with chondrocytes isolated from cartilage that was derived by curettage or shaver-minced cartilage that was augmented with PRP. After chondrogenic stimulation, the normalized proteoglycan content was higher in spheroids of cells derived from shaver-minced cartilage augmented with PRP than in spheroids of cells derived from curettage. A high correlation of cell outgrowth, proliferation capacity, and viability between isolated cells from all 3 groups taken from an individual donor was observed.
Conclusion:
Chondrocytes isolated from human cartilage tissue that was harvested and minced with an arthroscopic shaver remained viable and proliferative. The augmentation of shaver-minced cartilage with PRP led to the enhanced proteoglycan production of chondrogenic spheroids in vitro, pointing toward the development of a cartilage-specific extracellular matrix. This in vitro study yields promising results regarding the use of an arthroscopic shaver and augmentation with PRP in the context of MCI.
Clinical Relevance:
Knowledge that shaver mincing and augmentation with PRP are feasible for processing articular cartilage during MCI is highly relevant for surgical cartilage repair.
Introduction: Vessel-associated retinal diseases are a major cause of blindness and severe visual impairment. The identification of appropriate biomarkers is of great importance to better anticipate disease progression and establish more targeted treatment options. MicroRNAs (miRNAs) are short, single-stranded, noncoding ribonucleic acids that are involved in the posttranscriptional regulation of gene expression through hybridization with messenger RNA. The expression of certain miRNAs can be different in patients with pathological processes and can be used for the detection and differentiation of various diseases. In this study, we investigate to what extent previously in vitro identified miRNAs are present as cell-free circulating miRNAs in the serum and vitreous of human patients with and without vessel-associated retinal diseases. Methods: Relative quantification by quantitative real-time polymerase chain reaction was used to analyze miRNA expression in patients with vessel-associated retinal diseases such as age-related macular degeneration (AMD), diabetic retinopathy (DR), and retinal vein occlusion compared with control patients. Results: In serum samples, miR-29a-3p and miR-192-5p showed increased expression in patients with neovascular AMD relative to control patients. Similarly, miR-335-5p, miR-192-5p, and miR-194-5p showed increased expression in serum from patients with proliferative DR. In vitreous samples, miR-100-5p was decreased in patients with proliferative DR. Differentially expressed miRNAs showed good diagnostic accuracy in receiver operating characteristic (ROC) and area under the ROC curve analysis. Conclusion: The miRNAs investigated in this study may have the potential to serve as biomarkers for vessel-associated retinal diseases. Combining multiple miRNAs may enhance the predictive power of the analysis.
In future fusion reactors disruptions must be avoided at all costs. Disruptions due to the density limit (DL) are typically described by the power-independent Greenwald scaling. Recently, a power dependence of the disruptive DL was predicted by several authors (Zanca et al 2019 Nucl. Fusion 59 126011; Giacomin et al 2022 Phys. Rev. Lett. 128 185003; Singh and Diamond 2022 Plasma Phys. Control. Fusion 64 084004; Stroth et al 2022 Nucl. Fusion 62 076008; Brown and Goldston 2021 Nucl. Mater. Energy 27 101002). It is investigated whether this increases the operational range of the tokamak. Increasing the heating power in the L-mode can induce an L-H transition, and therefore a power-dependent DL and the L-H transition cannot be considered independently. The different models are tested on a data base for separatrix parameters at the separatrix of ASDEX Upgrade and compared with the concept (SepOS) presented in Eich and Manz (2021 Nucl. Fusion 61 086017). The disruptive separatrix density scales with the power ne ∝ P0.38±0.08 in good agreement to all models. Also the back transition from high to low (H-L) confinement shows an approximately Greenwald scaling with an additional power dependence ne ∝ P0.4 according to the SepOS concept. For future devices operating at much higher heating power such a power scaling may allow operation at much higher separatrix densities than are common in H-mode operation. Preconditions to extrapolation for future devices are discussed.
The pulse length dependence of a reactive high power impulse magnetron sputtering (HiPIMS) discharge with a tungsten cathode in an argon+oxygen gas mixture gas was investigated. The HiPIMS discharge is operated with a variable pulse length of 20–500 µs. Discharge current measurements, optical emission spectroscopy of neutral Ar, O, and W lines, and energy-resolved ion mass spectrometry are employed. A pronounced dependence of the discharge current on pulse length is noted while the initial discharge voltage is maintained constant. Energy-resolved mass spectrometry shows that the oxygen-to-tungsten (O+/W+) and the tungsten oxide-to-tungsten (WO+/W+) ion ratio decreases with pulse length due to target cleaning. Simulation results employing the SDTrimSP program show the formation of a non-stoichiometric sub-surface compound layer of oxygen which depends on the impinging ion composition and thus on the pulse length.
The current study analyzes the trajectory of the goose vowel in Received Pronunciation (RP) over ten decades (1920s-2010s). Recordings of eighty-seven RP speakers were transcribed in ELAN, and vowel tokens were extracted by FAVE, measuring F1 and F2 values at the midpoint. Showing the life-cycle of a sound change from start to (almost) completion, the results confirm that goose-fronting has been an active sound change for many decades in RP, with F2 starting to increase in the middle of the twentieth century and accelerated changes in the 1970s and the 2010s. We observe similar predictor strengths of linguistic factors as in previous studies. The results are interpreted in light of the social changes in the social composition of the RP group in the second part of the twentieth century, involving increased dialect contact.
Properties of self-excited dust acoustic waves under the influence of active compression of the dust particle system were experimentally studied in the laboratory and under microgravity conditions (parabolic flight). Ground based laboratory experiments clearly show that wave properties can be manipulated by changing the discharge volume, its aspect ratio, and thus the dust particle density. Complementary experiments under microgravity conditions, performed to exclude the effects of gravity inflicted sedimentation and anisotropic behavior, were less conclusive due to residual fluctuations in the planes acceleration indicating the need for a better microgravity environment. A theoretical model, using plasma parameters obtained from particle-in-cell simulations as input, supports the experimental findings. It shows that the waves can be described as a new observation of the dust acoustic mode, which demonstrates their generic character.
This article is the first to show that gender shapes the degree to which legislators use formal mechanisms to oversee government activities. Extensive scholarly work has analysed the use of oversight instruments, especially regarding who monitors whom. Whether, how, and why the conformity of men and women with institutional roles differs, has not yet received scholarly attention. We hypothesise that women become more active than men in overseeing the executive when in opposition while reducing their monitoring activities even more strongly than men when in government because of different social roles ascribed to men and women as well as differences in risk aversity between sexes. We analyse panel data for three oversight tools from the German Bundestag between 1949 and 2013 to test this proposition. Our findings imply that characteristics of political actors influence even a strongly institutionalised process as oversight and further clarify the gender bias in political representation.
Objective: In acute pancreatitis (AP), bacterial translocation and subsequent infection of pancreatic necrosis are the main risk factors for severe disease and late death. Understanding how immunological host defence mechanisms fail to protect the intestinal barrier is of great importance in reducing the mortality risk of the disease. Here, we studied the role of the Treg/Th17 balance for maintaining the intestinal barrier function in a mouse model of severe AP.
Design: AP was induced by partial duct ligation in C57Bl/6 or DEREG mice, in which regulatory T-cells (Treg) were depleted by intraperitoneal injection of diphtheria toxin. By flow cytometry, functional suppression assays and transcriptional profiling we analysed Treg activation and characterised T-cells of the lamina propria as well as intraepithelial lymphocytes (IELs) regarding their activation and differentiation. Microbiota composition was examined in intestinal samples as well as in murine and human pancreatic necrosis by 16S rRNA gene sequencing.
Results: The prophylactic Treg-depletion enhanced the proinflammatory response in an experimental mouse model of AP but stabilised the intestinal immunological barrier function of Th17 cells and CD8+/γδTCR+ IELs. Treg depleted animals developed less bacterial translocation to the pancreas. Duodenal overgrowth of the facultative pathogenic taxa Escherichia/Shigella which associates with severe disease and infected necrosis was diminished in Treg depleted animals.
Conclusion: Tregs play a crucial role in the counterbalance against systemic inflammatory response syndrome. In AP, Treg-activation disturbs the duodenal barrier function and permits translocation of commensal bacteria into pancreatic necrosis. Targeting Tregs in AP may help to ameliorate the disease course.
Decreased inflammatory profile in oral leukoplakia tissue exposed to cold physical plasma ex vivo
(2023)
Background
Oral leukoplakia (OL) is an unfavorable oral disease often resistant to therapy. To this end, cold physical plasma technology was explored as a novel therapeutic agent in an experimental setup.
Methods
Biopsies with a diameter of 3 mm were obtained from non-diseased and OL tissues. Subsequently, cold atmospheric pressure plasma (CAP) exposure was performed ex vivo in the laboratory. After 20 h of incubation, biopsies were cryo-conserved, and tissue sections were quantified for lymphocyte infiltrates, discriminating between naïve and memory cytotoxic and T-helper cells. In addition, the secretion pattern related to inflammation was investigated in the tissue culture supernatants by quantifying 10 chemokines and cytokines.
Results
In CAP-treated OL tissue, significantly decreased overall lymphocyte numbers were observed. In addition, reduced levels were observed when discriminating for the T-cell subpopulations but did not reach statistical significance. Moreover, CAP treatment significantly reduced levels of C-X-C motif chemokine 10 (CXCL10) and granulocyte-macrophage colony-stimulating factor in the OL biopsies' supernatants. In idiopathically inflamed tissues, ex vivo CAP exposure reduced T-cells and CXCL10 as well but also led to markedly increased interleukin-1β secretion.
Conclusion
Our findings suggest CAP to have immuno-modulatory properties, which could be of therapeutic significance in the therapy of OL. Future studies should investigate the efficacy of CAP therapy in vivo in a larger cohort.
Purpose
The significance of the underlying literature in clinical guidelines can be weakened by the risk of bias, which could negatively affect the recommendations. Especially in controversial matters, such as fluoride use for caries prevention in children, biased results may be not reliable and lead to incorrect conclusions. This study was performed to detect bias in underlying literature of the German guideline for caries prevention using fluoride in children, where no consensus was reached between paediatricians and paediatric dentists.
Methods
Three tools used for risk of bias assessments of different study designs were RoB 2 for RCTs, ROBINS-I for non-randomized studies, and ROBIS for systematic reviews. For each study cited in the guideline two independent risk of bias assessments were performed. Disagreements were resolved by consensus.
Results
Out of 58 papers, 48.3% (n = 28) showed high risk of bias, with the majority in sections regarding fluoride tablets, fluoridated toothpaste, and paediatricians’ recommendations. 9 out of 20 recommendations and statements were based on studies with high risk of bias, all of which were in these three controversial sections. 13 out of 29 RCTs showed high risk of bias (44.8%), as all 13 non-randomized trials did, while only 2 of 16 (12.5%) systematic reviews had high risk of bias.
Conclusion
Considering risk of bias of cited studies in clinical guidelines may result in substantial changes in its recommendations and aid in reaching consensus. Efforts should be made to assess risk of bias of underlying literature in future clinical guidelines.
Urbanization, industrialization, and intensification of agriculture have led to considerable heavy metal pollution across the globe, harming our ecosystems. Concentrations of arsenic (As), cadmium (Cd), copper (Cu), and lead (Pb) have been analysed in 249 eggshells collected between 2006 and 2021 from 83 female Common Cranes (Grus grus) nesting within north-eastern Germany. Information on the presence of trace elements in cranes from Europe and their potential adverse effects on the reproduction are largely missing. Only Cu and Pb were found to be present in eggshell samples. Levels of both metals did not exceed concentrations considered potentially toxic in birds and unhatched eggs did not contain higher metal concentrations compared to eggshell residues from hatched eggs. Statistical analysis revealed that trace element concentrations decreased significantly over the course of the study period. The ban of leaded gasoline in the early twenty-first century and strict limitations of heavy metal-based biocontrol products are likely responsible for this decrease over the years. However, as Cu levels gradually increase with increasing proportions of agricultural areas within the cranes’ home ranges, we suggest that considerable amounts of Cu originating from agricultural practises are still being released into the environment. We found no increase in metal concentrations in eggshells with increasing female age, suggesting that heavy metals do not accumulate in the circulatory systems of the adults over time. This study is the first to assess heavy metal contamination in Common Cranes and indicates the suitability of crane’s eggshells as bioindicator for monitoring environmental pollution.
Medieval texts reveal the normalised presence of Saami peoples in medieval Fennoscandia, suggesting close interactions involving trade, relationships, rituals, and magic. Despite growing recognition of these relations, the Saami remain overlooked in general studies of the Middle Ages, often relegated to symbolic roles or footnotes. As a result, Saami characters are typically depicted as the exotic Other within Norse society, often being stripped of agency and humanity in historical narratives. To counter these biases and distorted narratives, an essential step is analysing exclusionary structures in medieval literature and critically reviewing existing research on Saami representation. This process challenges dehumanising portrayals and confronts present-day stereotypes. The present study aims to ‘re-humanize’ (as Paulette F. C. Steeves puts it) the medieval Saami past by using decolonising frameworks and perspectives offered by the so-called ‘Indigenous turn’ of medieval studies, bridging medieval studies and Indigenous studies within a Norse context.
Comparative neuroanatomy of the central nervous system in web-building and cursorial hunting spiders
(2023)
Spiders (Araneae) include cursorial species that stalk their prey and more stationary species that use webs for prey capture. While many cursorial hunting spiders rely on visual cues, web-building spiders use vibratory cues (mechanosensation) for prey capture. We predicted that the differences in primary sensory input between the species are mirrored by differences in the morphology/architecture of the central nervous system (CNS). Here, we investigated the CNS anatomy of four spider species, two cursorial hunters Pardosa amentata (Lycosidae) and Marpissa muscosa (Salticidae), and two web-building hunters Argiope bruennichi (Araneidae) and Parasteatoda tepidariorum (Theridiidae). Their CNS was analyzed using Bodian silver impregnations, immunohistochemistry, and microCT analysis. We found that there are major differences between species in the secondary eye pathway of the brain that pertain to first-order, second-order, and higher order brain centers (mushroom bodies [MB]). While P. amentata and M. muscosa have prominent visual neuropils and MB, these are much reduced in the two web-building species. Argiope bruennichi lacks second-order visual neuropils but has specialized photoreceptors that project into two distinct visual neuropils, and P. tepidariorum lacks MB, suggesting that motion vision might be absent in this species. Interestingly, the differences in the ventral nerve cord are much less pronounced, but the web-building spiders have proportionally larger leg neuropils than the cursorial spiders. Our findings suggest that the importance of visual information is much reduced in web-building spiders, compared to cursorial spiders, while processing of mechanosensory information requires the same major circuits in both web-building and cursorial hunting spiders.
o-Hydroxyarylphosphanes are fascinating compounds by their multiple-reactivity features, attributed to the ambident hard and soft Lewis- and also Brønstedt acid-base properties, wide tuning opportunities via backbone substituents with ±mesomeric and inductive, at P and in o-position to P and O also steric effects, and in addition, the configurational stability at three-valent phosphorus. Air sensitivity may be overcome by reversible protection with BH3, but the easy oxidation to P(V)-compounds may also be used. Since the first reports on the title compounds ca. 50 years ago the multiple reactivity has led to versatile applications. This includes various P−E−O and P=C−O heterocycles, a multitude of O-substituted derivatives including acyl derivatives for traceless Staudinger couplings of biomolecules with labels or functional substituents, phosphane-phosphite ligands, which like the o-phosphanylphenols itself form a range of transition metal complexes and catalysts. Also main group metal complexes and (bi)arylphosphonium-organocatalysts are derived. Within this review the various strategies for the access of the starting materials are illuminated, including few hints to selected applications.
Aim
To investigate the medium-term associations of serum protein subfractions derived from proton nuclear magnetic resonance (1H-NMR) spectroscopy with periodontitis and tooth loss.
Materials and Methods
A total of 3031 participants of the cohort Study of Health in Pomerania (SHIP-TREND) were included. In addition to conventional serum testing, serum lipoprotein contents and subfractions were analysed by 1H-NMR spectroscopy. Confounder-adjusted associations of lipoprotein variables with periodontitis and the number of missing teeth variables were analysed using mixed-effects models with random intercepts for time across individuals, accounting for multiple testing.
Results
While only spurious associations between lipoprotein levels from conventional blood tests were found—that is, triglycerides were associated with mean clinical attachment level (CAL) and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio with the number of missing teeth - several associations emerged from serum lipoprotein subfractions derived from 1H-NMR analysis. Specifically, elevated LDL triglycerides were associated with higher levels of mean probing depth (PD), mean CALs, and increased odds of having <20 teeth. HDL-4 cholesterol levels were inversely associated with mean PD. Systemic inflammation (C-reactive protein) might mediate the effects of LDL and HDL triglyceride contents on periodontitis severity.
Conclusions
Several associations between serum lipoprotein subfractions and periodontitis were observed. As the underlying biochemical mechanisms remain unclear, further research is needed.
Aim
Climate change challenges temperate forest trees by increasingly irregular precipitation and rising temperatures. Due to long generation cycles, trees cannot quickly adapt genetically. Hence, the persistence of tree populations in the face of ongoing climate change depends largely on phenotypic variation, that is the capability of a genotype to express variable phenotypes under different environmental conditions, known as plasticity. We aimed to quantify phenotypic variation of central Europe's naturally dominant forest tree across various intraspecific scales (individuals, mother trees (families), populations) to evaluate its potential to respond to changing climatic conditions.
Location
Europe.
Time Period
2016–2019.
Major Taxa Studied
European beech (Fagus sylvatica L.).
Methods
We conducted a fully reciprocal transplantation experiment with more than 9000 beech seeds from seven populations across a Europe-wide gradient. We compared morphological (Specific Leaf Area), phenological (leaf unfolding) and fitness-related (growth, survival) traits across various biological scales: within single mother trees, within populations and across different populations under the contrasting climates of the translocation sites.
Results
The experiment revealed significant phenotypic variation within the offspring of each mother tree, regardless of geographic origin. Initially, seedling height growth varied among mother trees and populations, likely due to maternal effects. However, the growth performance successively aligned after the first year. In summary, we observed a consistent growth response in different beech populations to diverse environments after initial maternal effects.
Main Conclusions
The study strikingly demonstrates the importance of considering intraspecific variation. Given the surprisingly broad spectrum of phenotypes each mother tree holds within its juvenile offspring, we conclude that Fagus sylvatica might have the potential for medium-term population persistence in face of climate change, provided that this pattern persists into later life stages. Hence, we also suggest further investigating the inclusion of passive adaptation and natural dynamics in the adaptive management of forests.
Protein engineering is essential for altering the substrate scope, catalytic activity and selectivity of enzymes for applications in biocatalysis. However, traditional approaches, such as directed evolution and rational design, encounter the challenge in dealing with the experimental screening process of a large protein mutation space. Machine learning methods allow the approximation of protein fitness landscapes and the identification of catalytic patterns using limited experimental data, thus providing a new avenue to guide protein engineering campaigns. In this concept article, we review machine learning models that have been developed to assess enzyme-substrate-catalysis performance relationships aiming to improve enzymes through data-driven protein engineering. Furthermore, we prospect the future development of this field to provide additional strategies and tools for achieving desired activities and selectivities.
Boronate esters, formed by the reaction of an oligonucleotide bearing a 5′-boronic acid moiety with the 3′-terminal cis-diol of another oligonucleotide, support the assembly of functional nucleic acid architectures. Reversible formation of boronate esters occurs in templated fashion and has been shown to restore the activity of split DNA and RNA enzymes as well as a split fluorescent light-up aptamer. Apart from their suitability for the design and application of split nucleic acid enzymes and aptamers in the field of biosensing, boronate esters may have played an important role in early life as surrogates of the natural phosphodiester bond. Their formation is reversible and thus fulfills an important requirement for biological self-assembly. Here we discuss the general concept of stimuli-dependent boronate formation and its application in biomolecules with implications for future research.
Aim
To estimate association between the use of interdental cleaning aids (IDAs) and type on 7-year follow-up levels of interdental plaque, interdental gingival inflammation, interdental periodontitis severity, the number of interdental sound surfaces and the number of missing teeth in a population-based cohort study.
Materials and Methods
We used 7-year follow-up data of 2224 participants from the Study of Health in Pomerania (SHIP-TREND). We applied generalized linear and ordinal logistic models, adjusting for confounding and selection bias using inverse probability treatment weighting and multiple imputation.
Results
Flossers were 32% less likely to have higher interdental plaque (iPlaque) levels than non-users of IDAs (odds ratio [OR] = 0.68; 95% confidence interval [CI]: 0.50–0.94); flossing resulted in 5% lower means of iPlaque. Effects on interdental bleeding on probing (iBOP), mean interdental probing depths and mean interdental clinical attachment levels were direction-consistent but statistically non-significant. Interdental brushing was associated with lower follow-up levels for interdental plaque (OR = 0.73; 95% CI: 0.57–0.93) and iBOP (OR = 0.69; 95% CI: 0.53–0.89). IDAs were more effective in reducing iPlaque in participants with periodontitis, whereas iBOP reduction was more pronounced in participants with no or mild periodontitis. The analyses did not suggest that the use of IDAs affected caries. Finally, applying change score analyses, flossing reduced tooth loss incidence (incidence rate ratio [IRR] = 0.71) compared with non-users of IDAs.
Conclusions
Recommending flossing and interdental brushing in dental practices represents an approach to the prevention of gingivitis and consequently periodontitis.
Animals face strong environmental variability even on short time scales particularly in shallow coastal habitats, forcing them to permanently adjust their metabolism. Respiration rates of aquatic ectotherms are directly influenced by water temperature, whereas ingestion rates might additionally be influenced by behavior. We aim to understand how respiration and ingestion rates of an aquatic invertebrate respond to changing temperature during a diurnal thermal fluctuation cycle and how both processes are related. We studied the benthopelagic mysid Neomysis integer as an important food web component of coastal ecosystems. Mysids were collected at the southern Baltic Sea coast and exposed in the laboratory to either constant temperature of 15°C or daily temperature fluctuation of 15 ± 5°C. Short-term (1–2 h) respiration and ingestion rates were measured at four equidistant time points within 24 h and did not differ among time points at constant temperature, but differed among time points in the fluctuating treatment. Respiration was highest at the thermal maximum and lowest at the thermal minimum. Ingestion rates showed the opposite pattern under fluctuation, likely due to differences in underlying thermal performance curves. When temperature transited the average, the direction of temperature change influenced the animals' response in respiration and ingestion rates differently. Our results suggest that respiration is not only instantaneously affected by temperature, but also influenced by the previously experienced direction of thermal change. Our experiment, using an important non-model organism, delivered new insights on the relationship between the crucial organismal processes ingestion and respiration under thermal variability.
Introduction
The number of mentally altered patients a dentist meets in practice is increasing and interaction with them can be very challenging. As a baseline for an interventional study, we want to assess the attitude of dental students and identify areas of improvement in patient communication. This work compares the attitude of dental students towards people suffering from dementia to the attitudes of trained medical caregivers and the general population. Our aim is to use the results to assess the need for training in communicating with mentally altered patients.
Materials and Methods
Fourth-year dental students attended two lectures on dementia given by a psychiatrist as part of the geriatric dentistry lecture and were questioned afterwards using the Dementia Attitude Scale. In 2016 and 2017, 73 students at the University of Greifswald were interviewed. The response rate was 84%. Using a factor analysis, the Dementia Attitude Scale's validated questions were interpreted and compared with data from nursing staff from Switzerland and the USA.
Results
The factor analysis of the data showed the same two-factor loadings as the comparative groups, and that dental students' attitude is more comparable to the general population than to medically trained nursing staff.
Conclusion
Given the results, we conclude that the implementation of a communication module can serve in improving the attitude of dental students towards patients with dementia.
Poor sleep quality or sleep deprivation may be related to decreased bone mineral density. We aimed to assess whether associations of sleep characteristics and bone turnover or strength are present in adults from the general population and whether these are independent of common risk factors such as sex, age, and obesity. A total of 1037 participants from the Study of Health in Pomerania-TREND underwent laboratory-based polysomnography and quantitative ultrasound measurements at the heel. Of these participants, 804 completed standardised questionnaires to assess daytime sleepiness, insomnia, and sleep quality. Serum concentrations of two bone turnover markers, intact amino-terminal propeptide of type 1 procollagen (P1NP) and carboxy-terminal telopeptide of type 1 collagen (CTX) were measured. Cross-sectional associations of polysomnography variables (total sleep time, sleep efficiency, time spent wake after sleep onset, oxygen desaturation index, apnea–hypopnea index, and obstructive sleep apnea [OSA]), as well as sleep questionnaire scores with the bone turnover markers and the ultrasound-based stiffness index were assessed in linear regression models. In adjusted models, higher insomnia scores and lower sleep quality scores were related to a higher bone turnover in women but not in men. However, associations between polysomnography variables or questionnaire scores and the stiffness index were absent. Our study provides limited evidence for relationships between sleep characteristics and bone turnover and strength independent of common risk factors for OSA and osteoporosis. Nevertheless, women reporting poor sleep or insomnia in combination with risk factors for osteoporosis might benefit from an evaluation of bone health.
Changes in the microcirculation of the skin are a frequently observed accompanying phenomenon of many diseases, far beyond the spectrum of dermatological diseases. Not all of these changes are pathological, many are transient and have no serious consequences. This is true for many inflammatory diseases such as psoriasis vulgaris or atopic eczema.
However, there are also diseases in which functionally and morphologically recognizable microangiopathies lead to severe disease consequences. One of the most important diseases in this context is systemic sclerosis, an autoimmune systemic disease with multiple organ manifestations. Investigations of the cutaneous microcirculation are of great importance for the initial diagnosis as well as for prognosis and assessment of disease progression.
In peripheral hemodynamic disorders such as peripheral arterial disease (PAD) and chronic venous insufficiency (CVI), understanding microcirculatory disturbances also plays an important role in therapy and in monitoring the success of therapeutic interventions.
In this article, we address the transition of the Kolbe electrolysis of valeric acid (VA) to n-octane as an exemplary electrosynthesis process from a batch reaction to a continuous, self-regulated process. Based on a systematic assessment of chemical boundary conditions and sustainability aspects, we propose a continuous electrosynthesis including a simple product separation and electrolyte recirculation, as well as an online-pH-controlled VA feeding. We demonstrate how essential performance parameters such as product selectivity (S) and coulombic efficiency (CE) are significantly improved by the transition from batch to a continuous process. Thus, the continuous and pH-controlled electrolysis of a 1 M valeric acid, starting pH 6.0, allowed a constantly high selectivity of around 47 % and an average Coulomb efficiency about 52 % throughout the entire experimental duration. Under otherwise identical conditions, the conventional batch operation suffered from lower and strongly decreasing performance values (Sn-octane, 60min=10.4 %, Sn-octane, 240min=1.3 %; CEn-octane, 60min=7.1 %, CEn-octane, 240min=0.5 %). At the same time, electrolyte recirculation significantly reduces wastes and limits the use of electrolyte components.
Aims
To investigate factors that influence the willingness of inactive nurses to return to nursing in a crisis situation and to identify aspects that need to be considered with regard to a possible deployment.
Design
A deductive and inductive qualitative content analysis of semi-structured focus group interviews.
Methods
Semi-structured focus group interviews with inactive or marginally employed nurses, nurses who have been inactive for some time and nursing home managers in October and November 2021. The participating inactive nurses had declared their willingness for a deployment during the COVID-19 pandemic or not. Data were analysed using qualitative content analysis.
Results
Communication was seen as essential by the participants for an informed decision for or against a temporary return to nursing and to potential or actual deployments. To make them feel safe, inactive nurses need to know what to expect and what is expected of them, for example, regarding required training and responsibilities. Considering their current employment status, some flexibility in terms of deployment conditions is needed.
A remaining attachment to care can trigger a sense of duty. Knowledge of (regular) working conditions in nursing can lead to both a desire to support former colleagues and a refusal to be exposed to these conditions again.
Conclusion
Past working experiences and the current employment situation play a major role in the willingness of inactive nurses to return to nursing in a crisis situation. Unbureaucratic arrangements must be provided for those who are willing to return.
Summary Statement
What already is known - In crisis situations, not every inactive nurse is willing or able to return to nursing and therefore, the ‘silent reserve’ may not be as large as suspected.
What this paper adds - Inactive nurses need to know what to expect and what is expected of them for their decision regarding a return to active patient care during a crisis situation.
Implications for practice/policy – Inactive nurses need to be informed and should be offered free training and refresher courses to ensure patient safety.
Impact
This research shows that the group of inactive nurses are not a silent workforce which can be activated anytime. Those who are able and willing to return to direct patient care in crisis situations need the best possible support – during and between crises.
Reporting Method
This study adhered to COREQ guidelines.
No Patient or Public Contribution
The involvement of patients or members of the public did not apply for the study, as the aim was to gain insight into the motivations and attitudes of the group of inactive nurses.
Enzymatic degradation and recycling can reduce the environmental impact of plastics. Despite decades of research, no enzymes for the efficient hydrolysis of polyurethanes have been reported. Whereas the hydrolysis of the ester bonds in polyester‐polyurethanes by cutinases is known, the urethane bonds in polyether‐polyurethanes have remained inaccessible to biocatalytic hydrolysis. Here we report the discovery of urethanases from a metagenome library constructed from soil that had been exposed to polyurethane waste for many years. We then demonstrate the use of a urethanase in a chemoenzymatic process for polyurethane foam recycling. The urethanase hydrolyses low molecular weight dicarbamates resulting from chemical glycolysis of polyether‐polyurethane foam, making this strategy broadly applicable to diverse polyether‐polyurethane wastes.
Aim
To determine the long-term effects of the use of powered tooth brush (PTB) in comparison to manual tooth brush (MTB) on periodontitis severity, coronal caries experience, and the number of missing teeth using in a population-based cohort study.
Materials and Methods
Using 7-year follow-up data of 2214 participants of the Study of Health in Pomerania (SHIP-TREND), comprehensively adjusted linear models using generalized least squares and ordinal regression models estimated the effects of PTB usage on dental outcomes in complete case and imputed data.
Results
At follow-up, PTB users had lower medians for mean probing depth (PD; 2.21 mm) and mean clinical attachment levels (1.73 mm) than MTB users (2.30 and 1.96 mm, respectively). Adjusted models revealed the beneficial effects of PTB usage on follow-up levels of plaque, bleeding on probing, mean PD, percentage of sites with PDs ≥4 mm, mean clinical attachment levels (all, interdental, and non-interdental sites, respectively), and the number of missing teeth. For the number of missing teeth, the effects were more pronounced in participants aged ≥50 years. No significant effects of PTB usage on the number of decayed or filled surfaces (all and interdental sites) were found.
Conclusions
A recommendation of PTB usage in dental practice could contribute to the long-term promotion of oral health.
Aim
The aim of this study was to evaluate whether extraction thresholds in persons with severe periodontitis have changed between 2000 and 2010 and whether potential shifts have contributed to the reported decrease in tooth extractions in German adults over the last decades.
Materials and Methods
Data from two German population-based cohort studies in Northeast Germany (Studies of Health in Pomerania; SHIP-START [baseline 1997–2001; 11-year follow-up] and SHIP-TREND [baseline 2008–2012; 7-year follow-up]) were used. In SHIP-START (SHIP-TREND), 522 (478) participants with severe periodontitis according to the CDC/AAP case definition were included. Patterns of maximum probing depth (PD) and maximum clinical attachment level (CAL) for retained and extracted teeth were compared between SHIP-START and SHIP-TREND participants.
Results
No major differences in patterns of baseline maximum CAL of retained or extracted teeth were detected between SHIP-START and SHIP-TREND. Extraction thresholds were identified at the baseline at maximum CAL ≥6 and ≥9 mm. Tooth-level incidence rates for extraction for baseline maximum CAL of 6 mm were comparable between SHIP-START and SHIP-TREND (17.1 vs. 15.9 events per 1000 person-years).
Conclusions
After a decade, teeth in persons with severe periodontitis were still undergoing extraction with minor or moderate attachment loss. A change in extraction pattern did not contribute to the higher tooth retention rate.
Poly(vinyl alcohol) (PVA) is a water‐soluble synthetic vinyl polymer with remarkable physical properties including thermostability and viscosity. Its biodegradability, however, is low even though a large amount of PVA is released into the environment. Established physical‐chemical degradation methods for PVA have several disadvantages such as high price, low efficiency, and secondary pollution. Biodegradation of PVA by microorganisms is slow and frequently involves pyrroloquinoline quinone (PQQ)‐dependent enzymes, making it expensive due to the costly cofactor and hence unattractive for industrial applications. In this study, we present a modified PVA film with improved properties as well as a PQQ‐independent novel enzymatic cascade for the degradation of modified and unmodified PVA. The cascade consists of four steps catalyzed by three enzymes with in situ cofactor recycling technology making this cascade suitable for industrial applications.
For the characterization of Kv7.2/3 channel activators, several analytical methods are available that vary in effort and cost. In addition to the technically elaborate patch-clamp method, which serves as a reference method, there exist several medium to high-throughput screening methods including a rubidium efflux flame-atomic absorption spectrometry (F-AAS) assay and a commercial thallium uptake fluorescence-based assay. In this study, the general suitability of a graphite furnace atomic absorption spectrometry (GF-AAS)-based rubidium efflux assay as a screening method for Kv7.2/3 channel activators was demonstrated. With flupirtine serving as a reference compound, 16 newly synthesizedcompounds and the known Kv7.2/3 activator retigabine were first classified as either active or inactive by using the GF-AAS-based rubidium (Rb) efflux assay. Then, the results were compared with a thallium (Tl) uptake fluorescence-based fluorometric imaging plate reader (FLIPR) potassium assay. Overall, 16 of 17 compounds were classified by the GF-AAS-based assay in agreement with their channel-activating properties determined by the more expensive Tl uptake, fluorescence-based assay. Thus, the performance of the GF-AAS-based Rb assay for primary drug screening of Kv7.2/3-activating compounds was clearly demonstrated, as documented by the calculated Z’-factor of the GF-AAS-based method. Moreover, method development included optimization of the coating of the microtiter plates and the washing procedure, which extended the range of this assay to poorly adherent cells such as the HEK293 cells used in this study.
In temperate regions, climate warming alters temperature and precipitation regimes. During winter, a decline in insulating snow cover changes the soil environment, where especially frost exposure can have severe implications for soil microorganisms and subsequently for soil nutrient dynamics. Here, we investigated winter climate change responses in European beech forests soil microbiome. Nine study sites with each three treatments (snow exclusion, insolation, and ambient) were investigated. Long-term adaptation to average climate was explored by comparing across sites. Triplicated treatment plots were used to evaluate short-term (one single winter) responses. Community profiles of bacteria, archaea and fungi were created using amplicon sequencing. Correlations between the microbiome, vegetation and soil physicochemical properties were found. We identify core members of the forest-microbiome and link them to key processes, for example, mycorrhizal symbiont and specialized beech wood degraders (fungi) and nitrogen cycling (bacteria, archaea). For bacteria, the shift of the microbiome composition due to short-term soil temperature manipulations in winter was similar to the community differences observed between long-term relatively cold to warm conditions. The results suggest a strong link between the changes in the microbiomes and changes in environmental processes, for example, nitrogen dynamics, driven by variations in winter climate.
Being a master of metaphors
(2023)
Combining solid acid catalysts with enzyme reactions in aqueous environments is challenging because either very acidic conditions inactivate the enzymes, or the solid acid catalyst is neutralized. In this study, Amberlyst-15 encapsulated in polydimethylsiloxane (Amb-15@PDMS) is used to deprotect the lignin depolymerization product G−C2 dioxolane phenol in a buffered system at pH 6.0. This reaction is directly coupled with the biocatalytic reduction of the released homovanillin to homovanillyl alcohol by recombinant horse liver alcohol dehydrogenase, which is subsequently acylated by the promiscuous acyltransferase/hydrolase PestE_I208A_L209F_N288A in a one-pot system. The deprotection catalyzed with Amb-15@PDMS attains up to 97 % conversion. Overall, this cascade enables conversions of up to 57 %.
Baeyer-Villiger monooxygenases (BVMOs) are important flavin-dependent enzymes which perform oxygen insertion reactions leading to valuable products. As reported in many studies, BVMOs are usually unstable during application, preventing a wider usage in biocatalysis. Here, we discovered a novel NADPH-dependent BVMO which originates from Halopolyspora algeriensis using sequence similarity networks (SSNs). The enzyme is stable at temperatures between 10 °C to 30 °C up to five days after the purification, and yields the normal ester product. In this study, the substrate scope was investigated for a broad range of aliphatic ketones and the enzyme was biochemically characterized to identify optimum reaction conditions. The best substrate (86 % conversion) was 2-dodecanone using purified enzyme. This novel BVMO could potentially be applied as part of an enzymatic cascade or in bioprocesses which utilize aliphatic alkanes as feedstock.
In mandibulate arthropods, the primary olfactory centers, termed olfactory lobes in crustaceans, are typically organized in distinct fields of dense synaptic neuropils called olfactory glomeruli. In addition to olfactory sensory neuron terminals and their postsynaptic efferents, the glomeruli are innervated by diverse neurochemically distinctive interneurons. The functional morphology of the olfactory glomeruli is understudied in crustaceans compared with insects and even less well understood and described in a particular crustacean subgroup, the Peracarida, which embrace, for example, Amphipoda and Isopoda. Using immunohistochemistry combined with confocal laser scanning microscopy, we analyzed the neurochemistry of the olfactory pathway in the amphipod Parhyale hawaiensis. We localized the biogenic amines serotonin and histamine as well as the neuropeptides RFamide, allatostatin, orcokinin, and SIFamide. As for other classical neurotransmitters, we stained for γ-aminobutyric acid and glutamate decarboxylase and used choline acetyltransferase as indicator for acetylcholine. Our study is another step in understanding principles of olfactory processing in crustaceans and can serve as a basis for understanding evolutionary transformations of crustacean olfactory systems.
Boronate esters formed by reaction of an oligonucleotide carrying a 5′-boronic acid moiety with the 3′-terminal cis-diol of another have been shown previously to assist assembly of fragmented DNAzymes. Here we demonstrate that boronate esters replacing the natural phosphodiester linkage at selected sites of two functional RNAs, the hairpin ribozyme and the Mango aptamer, allow assembly of functional structures. The hairpin ribozyme, a small naturally occurring RNA that supports the reversible cleavage of appropriate RNA substrates, is very sensitive to fragmentation. Splitting the ribozyme at four different sites led to a significant decrease or even loss of cleavage and ligation activity. Ribozymes assembled from fragments capable of boronate ester formation showed restoration of cleavage activity in some but not all cases, dependent on the split site. Ligation proved to be more challenging, no supportive effect of the boronate ester was observed. Split variants of the Mango aptamer also showed a dramatic loss of functionality, which however, was restored when 5′-boronic acid modified fragments were used for assembly. These studies show for the first time that boronate esters as internucleoside linkages can act as surrogates of natural phosphodiesters in functional RNA molecules.
Amine transaminases (ATAs) are powerful biocatalysts for the stereoselective synthesis of chiral amines. Machine learning provides a promising approach for protein engineering, but activity prediction models for ATAs remain elusive due to the difficulty of obtaining high-quality training data. Thus, we first created variants of the ATA from Ruegeria sp. (3FCR) with improved catalytic activity (up to 2000-fold) as well as reversed stereoselectivity by a structure-dependent rational design and collected a high-quality dataset in this process. Subsequently, we designed a modified one-hot code to describe steric and electronic effects of substrates and residues within ATAs. Finally, we built a gradient boosting regression tree predictor for catalytic activity and stereoselectivity, and applied this for the data-driven design of optimized variants which then showed improved activity (up to 3-fold compared to the best variants previously identified). We also demonstrated that the model can predict the catalytic activity for ATA variants of another origin by retraining with a small set of additional data.
Chronic kidney disease is a major public health burden associated with a drastically reduced quality of living and life span that lacks suitable, individualized therapeutic strategies. Here we present a human induced pluripotent stem cell line (iPSC, UMGACBi001-A) reprogrammed from urine cells of an acute septic dialysis patient suffering from chronic kidney disease using non-integrating administration of RNAs. The generated iPSCs were positively characterized for typical morphology, pluripotency marker expression, directed differentiation potential, non-contamination, chromosomal consistency and donor identity. This iPSC-line can be a useful source for in vitro disease modelling and individualized therapeutic approaches.
Background and Aims
Hepatocellular ballooning is a common finding in chronic liver disease, mainly characterized by rarefied cytoplasm that often contains Mallory-Denk bodies (MDB). Ballooning has mostly been attributed to degeneration but its striking resemblance to glycogenotic/steatotic changes characterizing preneoplastic hepatocellular lesions in animal models and chronic human liver diseases prompts the question whether ballooned hepatocytes (BH) are damaged cells on the path to death or rather viable cells, possibly involved in neoplastic development.
Methods
Using specimens from 96 cirrhotic human livers, BH characteristics were assessed for their glycogen/lipid stores, enzyme activities, and proto-oncogenic signaling cascades by enzyme- and immunohistochemical approaches with serial paraffin and cryostat sections.
Results
BH were present in 43.8% of cirrhotic livers. Particularly pronounced excess glycogen storage of (glycogenosis) and/or lipids (steatosis) were characteristic, ground glass features and MDB were often observed. Decreased glucose-6-phosphatase, increased glucose-6-phosphate dehydrogenase activity and altered immunoreactivity of enzymes involved in glycolysis, lipid metabolism, and cholesterol biosynthesis were discovered. Furthermore, components of the insulin signaling cascade were upregulated along with insulin dependent glucose transporter glucose transporter 4 and the v-akt murine thymoma viral oncogene homolog/mammalian target of rapamycin signaling pathway associated with de novo lipogenesis.
Conclusions
BH are hallmarked by particularly pronounced glycogenosis with facultative steatosis, many of their features being reminiscent of metabolic aberrations documented in preneoplastic hepatocellular lesions in experimental animals and chronic human liver diseases. Hence, BH are not damaged entities facing death but rather viable cells featuring metabolic reprogramming, indicative of a preneoplastic nature.
Global and even national genome surveillance approaches do not provide the resolution necessary for rapid and accurate direct response by local public health authorities. Hence, a regional network of microbiological laboratories in collaboration with the health departments of all districts of the German federal state of Mecklenburg-Western Pomerania (M-V) was formed to investigate the regional molecular epidemiology of circulating SARS-CoV-2 lineages between 11/2020 and 03/2022. More than 4750 samples from all M-V counties were sequenced using Illumina and Nanopore technologies. Overall, 3493 (73.5%) sequences fulfilled quality criteria for time-resolved and/or spatially-resolved maximum likelihood phylogenic analyses and k-mean/ median clustering (KMC). We identified 116 different Pangolin virus lineages that can be assigned to 16 Nextstrain clades. The ten most frequently detected virus lineages belonged to B.1.1.7, AY.122, AY.43, BA.1, B.1.617.2, BA.1.1, AY.9.2, AY.4, P.1 and AY.126. Time-resolved phylogenetic analyses showed the occurrence of virus clades as determined worldwide, but with a substantial delay of one to two months. Further spatio-temporal phylogenetic analyses revealed a regional outbreak of a Gamma variant limited to western M-V counties. Finally, KMC elucidated a successive introduction of the various virus lineages into M-V, possibly triggered by vacation periods with increased (inter-) national travel activities. The COVID-19 pandemic in M-V was shaped by a combination of several SARS-CoV-2 introductions, lockdown measures, restrictive quarantine of patients and the lineage specific replication rate. Complementing global and national surveillance, regional surveillance adds value by providing a higher level of surveillance resolution tailored to local health authorities.
Counting of microbial colonies is a common technique employed in research and diagnostics. To simplify this tedious and time-consuming process, automated systems have been proposed. This study aimed to elucidate the reliability of automated colony counting. We evaluated a commercially available instrument (UVP ColonyDoc-It Imaging Station) in regard to its accuracy and potential time savings. Suspensions of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterococcus faecium, and Candida albicans (n = 20 each) were adjusted to achieve growth of approximately 1,000, 100, 10, and 1 colony per plate, respectively, after overnight incubation on different solid media. Compared with manual counting, each plate was automatically counted by the UVP ColonyDoc-It with and without visual adjustment on a computer display. For all bacterial species and concentrations automatically counted without visual correction, an overall mean difference from manual counts of 59.7%, a proportion of isolates with overestimation/underestimation of colony numbers of 29%/45%, respectively, and only a moderate relationship (R2 = 0.77) with the manual counting were shown. Applying visual correction, the overall mean difference from manual counts was 1.8%, the proportion of isolates with overestimation/underestimation of colony numbers amounted to 2%/42%, respectively, and a strong relationship (R2 = 0.99) with the manual counting was observed. The mean time needed for manual counting compared with automated counting without and with visual correction was 70 s, 30 s, and 104 s, respectively, for bacterial colonies through all concentrations tested. Generally, similar performance regarding accuracy and counting time was observed with C. albicans. In conclusion, fully automatic counting showed low accuracy, especially for plates with very high or very low colony numbers. After visual correction of the automatically generated results, the concordance with manual counts was high; however, there was no advantage in reading time.
IMPORTANCE Colony counting is a widely utilized technique in the field of microbiology. The accuracy and convenience of automated colony counters are essential for research and diagnostics. However, there is only sparse evidence on performance and usefulness of such instruments. This study examined the current state of reliability and practicality of the automated colony counting with an advanced modern system. For this, we thoroughly evaluated a commercially available instrument in terms of its accuracy and counting time required. Our findings indicate that fully automatic counting resulted in low accuracy, particularly for plates with very high or very low colony numbers. Visual correction of the automated results on a computer screen improved concordance with manual counts, but there was no benefit in counting time.
Neuroblastoma is the most common extracranial, malignant, solid tumor found in children. In more than one-third of cases, the tumor is in an advanced stage, with limited resectability. The treatment options include resection, with or without (neo-/) adjuvant therapy, and conservative therapy, the latter even with curative intent. Contrast-enhanced MRI is used for staging and therapy monitoring. Diffusion-weighted imaging (DWI) is often included. DWI allows for a calculation of the apparent diffusion coefficient (ADC) for quantitative assessment. Histological tumor characteristics can be derived from ADC maps. Monitoring the response to treatment is possible using ADC maps, with an increase in ADC values in cases of a response to therapy. Changes in the ADC value precede volume reduction. The usual criteria for determining the response to therapy can therefore be supplemented by ADC values. While these changes have been observed in neuroblastoma, early changes in the ADC value in response to therapy are less well described. In this study, we evaluated whether there is an early change in the ADC values in neuroblastoma under therapy; if this change depends on the form of therapy; and whether this change may serve as a prognostic marker. We retrospectively evaluated neuroblastoma cases treated in our institution between June 2007 and August 2014. The examinations were grouped as ‘prestaging’; ‘intermediate staging’; ‘final staging’; and ‘follow-up’. A classification of “progress”, “stable disease”, or “regress” was made. For the determination of ADC values, regions of interest were drawn along the borders of all tumor manifestations. To calculate ADC changes (∆ADC), the respective MRI of the prestaging was used as a reference point or, in the case of therapies that took place directly after previous therapies, the associated previous staging. In the follow-up examinations, the previous examination was used as a reference point. The ∆ADC were grouped into ∆ADCregress for regressive disease, ∆ADCstable for stable disease, and ∆ADC for progressive disease. In addition, examinations at 60 to 120 days from the baseline were grouped as er∆ADCregress, er∆ADCstable, and er∆ADCprogress. Any differences were tested for significance using the Mann–Whitney test (level of significance: p < 0.05). In total, 34 patients with 40 evaluable tumor manifestations and 121 diffusion-weighted MRI examinations were finally included. Twenty-seven patients had INSS stage IV neuroblastoma, and seven had INSS stage III neuroblastoma. A positive N-Myc expression was found in 11 tumor diseases, and 17 patients tested negative for N-Myc (with six cases having no information). 26 patients were assigned to the high-risk group according to INRG and eight patients to the intermediate-risk group. There was a significant difference in mean ADC values from the high-risk group compared to those from the intermediate-risk group, according to INRG. The differences between the mean ∆ADC values (absolute and percentage) according to the course of the disease were significant: between ∆ADCregress and ∆ADCstable, between ∆ADCprogress and ∆ADCstable, as well as between ∆ADCregress and ∆ADCprogress. The differences between the mean er∆ADC values (absolute and percentage) according to the course of the disease were significant: between er∆ADCregress and er∆ADCstable, as well as between er∆ADCregress and er∆ADCprogress. Forms of therapy, N-Myc status, and risk groups showed no further significant differences in mean ADC values and ∆ADC/er∆ADC. A clear connection between the ADC changes and the response to therapy could be demonstrated. This held true even within the first 120 days after the start of therapy: an increase in the ADC value corresponds to a probable response to therapy, while a decrease predicts progression. Minimal or no changes were seen in cases of stable disease.
Background
Understanding how SARS-CoV-2 affects respiratory centres in the brainstem may help to preclude assisted ventilation for patients in intensive care setting. Viral invasion appears unlikely, although autoimmunity has been implicated, the responsible antigens remain unknown. We previously predicted the involvement of three epitopes within distinct brainstem proteins: disabled homolog 1 (DAB1), apoptosis-inducing-factor-1 (AIFM1), and surfeit-locus-protein-1 (SURF1).
Methods
Here, we used microarrays to screen serum from COVID-19 patients admitted to intensive care and compared those with controls who experienced mild course of the disease.
Findings
The results confirm the occurrence of IgG and IgM antibodies against the hypothesised epitopes in COVID-19 patients. Importantly, while IgM levels were similar in both groups, IgG levels were significantly elevated in severely ill patients compared to controls, suggesting a pathogenic role of IgG.
Interpretation
The newly discovered anti-neuronal antibodies might be promising markers of severe disease and the targeted peptide epitopes might be used for targeted immunomodulation. Further work is needed to determine whether these antibodies may play a role in long-COVID.
Funding
AF, CF and PR received support from the German Research Foundation (grants FL 379/22-1, 327654276-SFB 1315, FR 4479/1-1, PR 1274/8-1). SH, DR, and DB received support from the Ministry of Economy, State of Mecklenburg Western Pomerania, Germany (grant COVIDPROTECT: “Optimisation of diagnostic and therapeutic pathways for COVID-19 patients in MV”). SH received support from the Research Group Molecular Medicine University of Greifswald (FVMM, seed funding FOVB-2021-01). AV received support from the Else Kröner Fresenius Foundation and the Alzheimer Research Initiative.
The cortical silent period (CSP), assessed with transcranial magnetic stimulation (TMS), provides insights into motor cortex excitability. Alterations in the CSP have been observed in multiple sclerosis (MS), although a comparison of the sometimes contradictory results is difficult due to methodological differences. The aim of this study is to provide a more profound neurophysiological understanding of fatigue’s pathophysiology and its relationship to the CSP. Twenty-three patients with MS, along with a matched control group, underwent comprehensive CSP measurements at four intensities (125, 150, 175, and 200% resting motor threshold), while their fatigue levels were assessed using the Fatigue Scale for Motor and Cognitive Functions (FSMC) and its motor and cognitive subscore. MS patients exhibited a significantly increased CSP duration compared to controls (p = 0.02), but CSP duration was not associated with the total FSMC, or the motor or cognitive subscore. Our data suggest a systematic difference in MS patients compared to healthy controls in the CSP but no association with fatigue when measured with the FSMC. Based on these results, and considering the heterogeneous literature in the field, our study highlights the need for a more standardized approach to neurophysiological data collection and validation. This standardization is crucial for exploring the link between TMS and clinical impairments in diseases like MS.
Immunotherapies against high-risk neuroblastoma (NB), using the anti-GD2 antibody (Ab) dinutuximab beta (DB), significantly improved patient survival. Ab-dependent cellular cytotoxicity (ADCC) is one of the main mechanisms of action and it is primarily mediated by NK cells. To further improve antitumor efficacy, we investigated here a combinatorial immunotherapy with DB and the double immune checkpoint blockade of T-cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT) and programmed cell death ligand-1 (PD-L1). The effects of ADCC, mediated by DB against NB cells on NK-cell activity, and the expression of TIGIT and CD226 and their ligands CD112 and CD155, as well as of PD-1 and PD-L1 on NB and effector cells, were investigated using flow cytometry. ADCC was assessed with a calcein-AM-based cytotoxicity assay. The efficacy of a combinatorial immunotherapy with DB, given as a long-term treatment, and the double immune checkpoint blockade of TIGIT and PD-L1 was shown using a resistant murine model of NB, followed by an analysis of the tumor tissue. We detected both TIGIT ligands, CD112 and CD155, on all NB cell lines analyzed. Although ADCC by DB resulted in a strong activation of NK cells leading to an effective tumor cell lysis, a remarkable induction of PD-L1 expression on NB cells, and of TIGIT and PD-1 on effector cells, especially on NK cells, was observed. Additional anti-TIGIT or anti-PD-L1 treatments effectively inhibited tumor growth and improved survival of the mice treated with DB. The superior antitumor effects were observed in the “DB + double immune checkpoint blockade” group, showing an almost complete eradication of the tumors and the highest OS, even under resistant conditions. An analysis of tumor tissue revealed both TIGIT and TIGIT ligand expression on myeloid-derived suppressor cells (MDSCs), suggesting additional mechanisms of protumoral effects in NB. Our data show that the targeting of TIGIT and PD-L1 significantly improves the antitumor efficacy of anti-GD2 immunotherapy, with DB presenting a new effective combinatorial treatment strategy against high-risk tumors.
This study investigated, if a mixed electroactive bacterial (EAB) culture cultivated heterotrophically at a positive applied potential could be adapted from oxidative to reductive or bidirectional extracellular electron transfer (EET). To this end, a periodic potential reversal regime between − 0.5 and 0.2 V vs. Ag/AgCl was applied. This yielded biofilm detachment and mediated electroautotrophic EET in combination with carbonate, i.e., dissolved CO2, as the sole carbon source, whereby the emerged mixed culture (S1) contained previously unknown EAB. Using acetate (S2) as well as a mixture of acetate and carbonate (S3) as the main carbon sources yielded primarily alternating electrogenic organoheterotropic metabolism with the higher maximum oxidation current densities recorded for mixed carbon media, exceeding on average 1 mA cm−2. More frequent periodic polarization reversal resulted in the increase of maximum oxidative current densities by about 50% for S2-BES and 80% for S3-BES, in comparison to half-batch polarization. The EAB mixed cultures developed accordingly, with S1 represented by mostly aerobes (84.8%) and being very different in composition to S2 and S3, dominated by anaerobes (96.9 and 96.5%, respectively). S2 and S3 biofilms remained attached to the electrodes. There was only minor evidence of fully reversible bidirectional EET. In conclusion the three triplicates fed with organic and/or inorganic carbon sources demonstrated two forms of diauxie: Firstly, S1-BES showed a preference for the electrode as the electron donor via mediated EET. Secondly, S2-BES and S3-BES showed a preference for acetate as electron donor and c-source, as long as this was available, switching to CO2 reduction, when acetate was depleted.
The impact of the COVID-19 pandemic on social-emotional developmental risks (SE-DR) of preschool children is largely unknown. Therefore, the aim of this prospective longitudinal dynamic cohort study was to assess changes in preschoolers’ SE-DR from before the pandemic to after the first COVID-19 wave. SE-DR were assessed annually with the instrument “Dortmund Developmental Screening for Preschools” (DESK). Longitudinal DESK data from 3- to 4-year-old children who participated both in survey wave (SW) three (DESK-SW3, 2019) and SW four (DESK-SW4, 2020) from August 1 to November 30 were used, respectively. Additionally, data from previous pre-pandemic SW were analyzed to contextualize the observed changes (SW1: 2017; SW2: 2018). A total of N = 786 children were included in the analysis. In the pre-pandemic DESK-SW3, the proportion of children with SE-DR was 18.2%, whereas in DESK-SW4 after the first COVID-19 wave, the proportion decreased to 12.4% (p = 0.001). Thus, the prevalence rate ratio (PRR) was 0.68. Compared to data from previous SW (SW1-SW2: PRR = 0.88; SW2-SW3: PRR = 0.82), this result represents a notable improvement. However, only short-term effects were described, and the study region had one of the highest preschool return rates in Germany. Further studies are needed to examine long-term effects of the pandemic on preschoolers’ SE-DR.
Background
The ‘wallflower’ hypothesis proposes females mate indiscriminately to avoid reproductive delays. Post-copulatory mechanisms may then allow ‘trading up’, favouring paternity of future mates. We tested links between pre- and post-copulatory choice in Latrodectus geometricus female spiders paired sequentially with two males. These females copulate as adults or as subadults and store sperm in paired spermathecae. Choosy adults have a higher risk of delays to reproduction than subadults.
Results
We predicted low pre-copulatory, but high post-copulatory choice at first matings for adults and the opposite for subadults. At second matings, we expected all females would prefer males superior to their first. We found all females mated indiscriminately at their first pairing, but in contrast to subadults, adults usually allowed only a single insertion (leaving one of their paired spermatheca empty); a mechanism of post-copulatory choosiness. Adult-mated females were more likely to remate than subadult-mated females when they became adults, showing a preference for larger males, while subadult-mated females tended to prefer males of greater size-corrected mass.
Conclusions
Our results show that the ‘wallflower’ effect and ‘trading up’ tactics can be utilized at different life stages, allowing females to employ choice even if rejecting males is costly.
This dynamic cohort was established to evaluate the targeted individual promotion of children affected by developmental risks as part of the German federal state law for child day-care and preschools in Mecklenburg-Western Pomerania. The project has been conducted in preschools in regions with a low socio-economic profile since 2011. Since 2017, the revision of the standardized Dortmund Developmental Screening for Preschools (DESK 3–6 R) has been applied. Developmental risks of 3 to 6-year-old children in the domains of motor, linguistic, cognitive and social competencies are monitored. The cohort is followed up annually. In 2020, n = 7,678 children from n = 152 preschools participated. At the baseline (2017), n = 8,439 children participated. Due to the defined age range of this screening, 3,000 to 4,000 5-6-year-old children leave the cohort annually. Simultaneously, an approximately equal number of 3-year-old children enters the cohort per survey wave. N = 702 children participated in all 4 survey waves. On the basis of DESK 3–6 R scores available from survey waves 2017 to 2019 it is possible to compute expected values for the survey wave 2020 and to compare those with the measured values to evaluate the effects of the COVID-19 pandemic (i.e. parental home care due to restrictions related to COVID-19).
Background
Only about half the people with depression seek professional health care services. To constitute the different predictors and associating variables of health care utilisation, we model the process and aim to test our hypothesised Seeking Mental Health Care Model. The model includes empirical influences on the help-seeking process to predict actual behaviour and incorporates superordinate (stigma, treatment experiences) as well as intermediate attitudinal variables (continuum and causal beliefs, depression literacy and self-efficacy).
Method
All variables are examined in an online study (baseline, three- and six-month follow-up). The sample consisted of adults with depressive symptoms (PHQ-9 sum score ≥ 8), currently not receiving mental health care treatment. To examine the prediction of variables explaining help-seeking behaviour, a path model analysis was carried out (lavaan package, software R).
Results
Altogether, 1368 participants (Mage = 42.38, SDage = 15.22, 65.6% female) were included, 983 participating in at least one follow-up. Model fit was excellent (i.e., RMSEA = 0.059, CFI = 0.989), and the model confirmed most of the hypothesised predictions. Intermediary variables were significantly associated with stigma and experiences. Depression literacy (ß = .28), continuum beliefs (ß = .11) and openness to a balanced biopsychosocial causal model (ß = .21) significantly influenced self-identification (R2 = .35), which among the causal beliefs and self-efficacy influenced help-seeking intention (R2 = .10). Intention (ß = .40) prospectively predicted help-seeking behaviour (R2 = .16).
Conclusion
The Seeking Mental Health Care Model provides an empirically validated conceptualisation of the help-seeking process of people with untreated depressive symptoms as a comprehensive approach considering internal influences. Implications and open questions are discussed, e.g., regarding differentiated assessment of self-efficacy, usefulness of continuum beliefs and causal beliefs in anti-stigma work, and replication of the model for other mental illnesses.
Trial registration
German Clinical Trials Register: DRKS00023557. Registered 11 December 2020. World Health Organization, Universal Trial Number: U1111–1264-9954. Registered 16 February 2021.
Although serious accidents remain the leading cause of pediatric mortality, protocols to orient diagnostic procedures towards a certain type of initial imaging are widely needed. Since 2007, we have performed whole-body magnetic resonance imaging (WBMR) and whole-body computed tomography (WBCT) for diagnoses of severely injured children. We retrospectively reviewed 134 WBMR and 158 WBCT in patients younger than 16 years that were performed at two trauma centers between 2007 and 2018. A higher Injury Severity Score (ISS) was found in WBCT vs. WBMR (10.6 vs. 5.8; p = 0.001), but without any significant difference in mortality. The WBMR was significantly preferred at younger ages (9.6 vs. 12.8 years; p < 0.001). The time between patient’s arrival until diagnosis was 2.5 times longer for WBCT (92.1 vs. 37.1 min; p < 0.001). More patients in the CT group received analgesic sedation and/or intubation at 37.3% vs. 21.6% in the MRI group. Of these patients, 86.4% (CT) and 27.6% (MRI) were already preclinically sedated (p < 0.001). Correspondingly, 72.4% of the patients were first sedated in-hospital for MRIs. In conclusion, WBMR is an alternative and radiation-free imaging method for high-energy-traumatized children. Although the selected diagnostics seemed appropriate, limitations regarding longer duration or additional analgesic sedation are present, and further studies are needed.
Treatment of high-risk neuroblastoma (NB) patients with the anti-GD2 antibody (Ab) dinutuximab beta (DB) improves survival by 15%. Ab-dependent cellular cytotoxicity (ADCC) is the major mechanism of action and is primarily mediated by NK cells. Since IL-2 co-treatment did not show a therapeutic benefit but strongly induced Treg, we investigated here a DB-based immunotherapy combined with the immunocytokine FAP-IL-2v, which comprises a fibroblast activation protein α (FAP)-specific Ab linked to a mutated IL-2 variant (IL-2v) with abolished binding to the high-affinity IL-2 receptor, thus stimulating NK cells without induction of Treg. Effects of FAP-IL-2v on NK cells, Treg and ADCC mediated by DB, as well as FAP expression in NB, were investigated by flow cytometry, calcein-AM-based cytotoxicity assay and RT-PCR analysis. Moreover, the impact of soluble factors released from tumor cells on FAP expression by primary fibroblasts was assessed. Finally, a combined immunotherapy with DB and FAP-IL-2v was evaluated using a resistant syngeneic murine NB model. Incubation of leukocytes with FAP-IL-2v enhanced DB-specific ADCC without induction of Treg. FAP expression on NB cells and myeloid-derived suppressor cells (MDCS) in tumor tissue was identified. A tumor-cell-dependent enhancement in FAP expression by primary fibroblasts was demonstrated. Combination with DB and FAP-IL-2v resulted in reduced tumor growth and improved survival. Analysis of tumor tissue revealed increased NK and cytotoxic T cell numbers and reduced Treg compared to controls. Our data show that FAP-IL-2v is a potent immunocytokine that augments the efficacy of DB against NB, providing a promising alternative to IL-2.
Platelet adhesion and spreading at the sites of vascular injury is vital to hemostasis. As an integral part of the innate immune system, platelets interact with opsonized bacterial pathogens through FcγRIIA and contribute to host defense. As mechanoscavangers, platelets actively migrate and capture bacteria via cytoskeleton-rich, dynamic structures, such as filopodia and lamellipodia. However, the role of human platelet FcγRIIA in cytoskeleton-dependent interaction with opsonized bacteria is not well understood. To decipher this, we used a reductionist approach with well-defined micropatterns functionalized with immunoglobulins mimicking immune complexes at planar interfaces and bacteriamimetic microbeads. By specifically blocking of FcγRIIA and selective disruption of the platelet cytoskeleton, we show that both functional FcγRIIA and cytoskeleton are necessary for human platelet adhesion and haptotaxis. The direct link between FcγRIIA and the cytoskeleton is further explored by single-particle tracking. We then demonstrate the relevance of cytoskeleton-dependent differential mobilities of FcγRIIA on bacteria opsonized with the chemokine platelet factor 4 (PF4) and patient-derived anti-PF4/polyanion IgG. Our data suggest that efficient capture of opsonized bacteria during host-defense is governed by mobility dynamics of FcγRIIA on filopodia and lamellipodia, and the cytoskeleton plays an essential role in platelet morphodynamics at biological interfaces that display immune complexes.
Hand hygiene is a cornerstone of infection prevention. However, few data are available for school children on their knowledge of infectious diseases and their prevention. The aim of the study was to develop and apply a standardized questionnaire for children when visiting primary schools to survey their knowledge about infectious diseases, pathogen transmission and prevention measures. Enrolling thirteen German primary schools, 493 questionnaires for grade three primary school children were included for further analyses, comprising 257 (52.1%) girls and 236 (47.9%) boys with an age range of 8–11 years. Out of 489 children, 91.2% participants indicated that they knew about human-to-human transmissible diseases. Of these, 445 children responded in detail, most frequently mentioning respiratory and gastrointestinal diseases, followed by childhood diseases. Addressing putative hygiene awareness-influencing factors, it was worrisome that more than 40.0% of the children avoided visiting the sanitary facilities at school. Most of the children (82.9%) noted that they did not like to use the sanitary facilities at school because of their uncleanliness and the poor hygienic behavior of their classmates. In conclusion, basic infection awareness exists already in primary school age children. Ideas about the origin and prevention of infections are retrievable, however, this knowledge is not always accurate and adequately contextualized. Since the condition of sanitary facilities has a strong influence on usage behavior, the child’s perspective should be given more consideration in the design and maintenance of sanitary facilities.
Osteoporosis, a complex chronic disease with increasing prevalence, is characterised by reduced bone mineral density (BMD) and increased fracture risk. The high heritability of BMD suggests substantial impact of the individual genetic disposition on bone phenotypes and the development of osteoporosis. In the past years, genome-wide association studies (GWAS) identified hundreds of genetic variants associated with BMD or osteoporosis. Here, we analysed 1103 single nucleotide polymorphisms (SNPs), previously identified as associated with estimated BMD (eBMD) in the UK Biobank. We assessed whether these SNPs are related to heel stiffness index obtained by quantitative ultrasound in 5665 adult participants of the Study of Health in Pomerania (SHIP). We confirmed 45 significant associations after correction for multiple testing. Next, we analysed six selected SNPs in 631 patients evaluated for osteoporosis [rs2707518 (CPED1/WNT16), rs3779381 (WNT16), rs115242848 (LOC101927709/EN1), rs10239787 (JAZF1), rs603424 (PKD2L1) and rs6968704 (JAZF1)]. Differences in minor allele frequencies (MAF) of rs2707518 and rs3779381 between SHIP participants (higher MAF) and patients evaluated for osteoporosis (lower MAF) indicated a protective effect of the minor allele on bone integrity. In contrast, differences in MAF of rs603424 indicated a harmful effect. Co-localisation analyses indicated that the rs603424 effect may be mediated via stearoyl-CoA desaturase (SCD) expression, an enzyme highly expressed in adipose tissue with a crucial role in lipogenesis. Taken together, our results support the role of the WNT16 pathway in the regulation of bone properties and indicate a novel causal role of SCD expression in adipose tissue on bone integrity.
Background
Short-term infusions of dinutuximab beta plus isotretinoin and cytokines administered in previous immunotherapy studies in neuroblastoma were associated with severe pain. Here, long-term, continuous infusion of single-agent dinutuximab beta was evaluated in patients with relapsed/refractory neuroblastoma.
Methods
In this open-label, single-arm, Phase 2 study, patients with either refractory or relapsed high-risk neuroblastoma received dinutuximab beta by continuous infusion over 10 days of each cycle, for up to five cycles. The primary endpoint was objective response rate 24 weeks after the end of cycle 5. Secondary endpoints included adverse events, intravenous morphine use, best response, duration of response, and three-year progression-free and overall survival.
Results
Of the 40 patients included, 38 had evaluable response. Objective response rate was 26% and best response rate 37%. Median duration of response was 238 days (IQR 108–290). Three-year progression-free and overall survival rates were 31% (95% CI 17–47) and 66% (95% CI 47–79), respectively. Prophylactic intravenous morphine use and duration of use decreased with increasing cycles. The most common grade 3 treatment-related adverse events were pain, diarrhea, and hypokalemia.
Conclusion
Long-term continuous infusion of single-agent dinutuximab beta is tolerable and associated with clinically meaningful responses in patients with relapsed/refractory high-risk neuroblastoma.
Clinical trial registration
The study is registered with ClinicalTrials.gov (NCT02743429) and EudraCT (2014-000588-42).
Numerous insertions of mitochondrial DNA in the genome of the northern mole vole, Ellobius talpinus
(2024)
Background
Ellobius talpinus is a subterranean rodent representing an attractive model in population ecology studies due to its highly special lifestyle and sociality. In such studies, mitochondrial DNA (mtDNA) is widely used. However, if nuclear copies of mtDNA, aka NUMTs, are present, they may co-amplify with the target mtDNA fragment, generating misleading results. The aim of this study was to determine whether NUMTs are present in E. talpinus.
Methods and results
PCR amplification of the putative mtDNA CytB-D-loop fragment using ‘universal’ primers from 56 E. talpinus samples produced multiple double peaks in 90% of the sequencing chromatograms. To reveal NUMTs, molecular cloning and sequencing of PCR products of three specimens was conducted, followed by phylogenetic analysis. The pseudogene nature of three out of the seven detected haplotypes was confirmed by their basal positions in relation to other Ellobius haplotypes in the phylogenetic tree. Additionally, ‘haplotype B’ was basal in relation to other E. talpinus haplotypes and found present in very distant sampling sites. BLASTN search revealed 195 NUMTs in the E. talpinus nuclear genome, including fragments of all four PCR amplified pseudogenes. Although the majority of the NUMTs studied were short, the entire mtDNA had copies in the nuclear genome. The most numerous NUMTs were found for rrnL, COXI, and D-loop.
Conclusions
Numerous NUMTs are present in E. talpinus and can be difficult to discriminate against mtDNA sequences. Thus, in future population or phylogenetic studies in E. talpinus, the possibility of cryptic NUMTs amplification should always be taken into account.
Objective
To conduct a systematic review of the published scientific evidence to evaluate the efficacy of nonsurgical periodontal therapy (NSPT) in treating periodontitis in patients with concurrent systemic conditions (diabetes, CVD, erectile dysfunction, chronic kidney disease, rheumatoid arthritis, polycystic ovarian syndrome, obesity, pregnancy). We hypothesised that NSPT results in better periodontal outcomes when compared to untreated controls after follow-up.
Materials and methods
A systematic search (PUBMED/EMBASE) was conducted from 1995 to 2023 to identify randomised controlled trials (RCTs) with a minimum follow-up of 3 months. The primary outcome was the difference in mean probing depth (PD), and the secondary outcomes were mean clinical attachment loss (CAL), percentage of sites with PD ≤ 3 mm (%PD ≤ 3 mm) and percentage of sites with bleeding on probing (%BOP) between the treated and untreated control group in patients with comorbidities.
Results
The electronic search resulted in 2,403 hits. After removing duplicates, 1,565 titles and abstracts were screened according to the eligibility criteria, resulting in 126 articles for full-text screening. Following this, 44 studies were analysed. Restricting to studies with low bias or some concerns, NSPT group demonstrated a 0.55 mm lower mean PD (95%CI: −0.69; −0.41) after 3 months compared to the control group.
Conclusion
Compared to the untreated controls, NSPT notably reduced mean PD, mean CAL, and %BOP while increasing %PD ≤ 3 mm in patients with concurrent systemic conditions. These findings suggest that NSPT is also an effective procedure in managing periodontitis in patients with concurrent systemic conditions.
Trial registration
This systematic review was registered under the protocol registration number CRD42021241517/PROSPERO.
Binding of general transcription factors TFIID and TFIIA to basal promoters is rate-limiting for transcriptional initiation of eukaryotic protein-coding genes. Consequently, activator proteins interacting with subunits of TFIID and/or TFIIA can drastically increase the rate of initiation events. Yeast transcriptional activator Ino2 interacts with several Taf subunits of TFIID, among them the multifunctional Taf1 protein. In contrast to mammalian Taf1, yeast Taf1 lacks bromodomains which are instead encoded by separate proteins Bdf1 and Bdf2. In this work, we show that Bdf1 not only binds to acetylated histone H4 but can also be recruited by Ino2 and unrelated activators such as Gal4, Rap1, Leu3 and Flo8. An activator-binding domain was mapped in the N-terminus of Bdf1. Subunits Toa1 and Toa2 of yeast TFIIA directly contact sequences of basal promoters and TFIID subunit TBP but may also mediate the influence of activators. Indeed, Ino2 efficiently binds to two separate structural domains of Toa1, specifically with its N-terminal four-helix bundle structure required for dimerization with Toa2 and its C-terminal β-barrel domain contacting TBP and sequences of the TATA element. These findings complete the functional analysis of yeast general transcription factors Bdf1 and Toa1 and identify them as targets of activator proteins.
Neutron scattering is a very high-performance method for studying the structure and dynamics of condensed matter with similar approaches in wide ranges of space and time, matching dimensions in space from single atoms to macromolecules and in time from atomic vibrations over crystal phonons to low-lying transitions in the microwave range, and to motions of large molecular units. Concerning the number and depth of physical concepts, neutron scattering may be compared to modern nuclear magnetic resonance. Neutrons have contributed essential results to the understanding of atomic and molecular processes and are, in this respect, complementary to other materials science probes. Among others, three properties of thermal neutrons make them especially appropriate for such work: the neutron mass is similar to atomic masses, and both neutron energies and the wavelengths of the neutron material wave match typical values for condensed matter. A further important feature of neutron scattering, making it especially valuable in biochemistry and polymer sciences, is that hydrogen and deuterium atoms very significantly and specifically contribute to the signal in both diffraction and spectroscopy. Additionally, neutrons are scattered at the nuclei and directly reflect the nuclear structure and motions. Results from neutron scattering are of great general interest. This paper aims to provide an introduction for chemists on a level understandable also to students and researchers who are not going to become part of the neutron community and will not be involved in the experiments, but shall be able to understand the basic concepts of the method and its relevance to modern chemistry. The paper focuses on basic theory, typical experiments, and some examples demonstrating the applications. As for many modern experimental techniques, the interpretation of the results of neutron scattering is based on theoretical models and requires a significant mathematical overhead. Most results are only meaningful when compared with computer simulations. For understanding this, in this paper, the theory of scattering is developed, starting with intuitive models and presenting typical concepts such as the scattering triangle, energy and momentum transfer, and the relation of inelastic and elastic scattering to space- and time-dependent information. The interaction of neutrons with matter, scattering cross sections, beam attenuation, and coherent versus incoherent scattering are explained in detail. Two further typical concepts that are not generally familiar to scientists outside the community are the use of wave and particle equivalence, and of handling results as a scattering function that depends simultaneously on momentum and energy transfers. The possibility of obtaining neutron beams for scattering experiments at a few research centers around high-performance sources is explained, and experimentally relevant features of research reactors and spallation sources are mentioned. As neutron experiments always have to deal with small flux and extended beams and shielding, experimental conditions are very far away from laboratory methods where handling of samples and instruments is concerned. Experimental details are given for making experiments more understandable and familiarizing the reader with the method. Related to this are extended possibilities for handling samples in a large variety of different environments. In a further part of the manuscript, a variety of techniques and typical instruments are presented, together with some characteristic applications bringing alive the theory developed so far. This covers powder diffraction and structure of liquid water, triple-axis spectrometers and lattice phonons, backscattering spectrometry and rotational tunneling, time-of-flight spectrometry, and simultaneously probing the energy and shape of low lying vibrations and diffusion, filter spectrometer and vibrational spectroscopy without selection rules, small-angle neutron scattering and protein unfolding, as well as micelles, neutron spin echo spectroscopy, and polymer dynamics.
Lack of a shared vision has been identified as a major obstacle in transdisciplinary research involving both scientists and other stakeholders. Without a shared vision, the implementation of scientific findings is difficult. The diverse partners of collaborative research, however, imply a plurality in the valuation of nature and a need for deliberative mechanisms. If visioning processes are to do justice to local contexts, research must apply deliberative mechanisms to cover the plurality in the valuation of nature. This paper proposes a visioning approach for local communities, based on prior transdisciplinary research. This participatory workshop method invites stakeholders to approach nature conservation and livelihoods via a deliberation of desirable futures, barriers for achieving them and associated responsibilities for taking action. The paper explores this method via a case study of visioning workshops on sacred swamps in the Western Ghats (India), and their role for both freshwater swamp protection and livelihoods. The visioning exercise offered discussion opportunities facilitating conscientization, conciliation and collaboration in local bottom-up nature conservation. For conserving the tropical freshwater swamps, the results show the need for a more participatory forest governance, providing space for shared value creation. They also point to the need for further research on inter-faith nature conservation possibilities, along with innovations on value addition and value chain development for livelihood promotion and protection.
The cultivation of common reed (Phragmites australis) is one of the most promising practices of paludiculture on fen peatlands. This highly productive grass has a high adaptation capacity via high levels of genetic diversity and phenotypic plasticity. In this study, a reed experimental site established on a degraded fen in 1996/97 with a mixture of monoclonally (meristematically propagated plantlets) and polyclonally (pre-grown seedlings) planted plots was investigated by microsatellite genotyping. All nine genotypes of the monoclonal planted plots were recovered and could be genetically characterized; invasion by other genotypes was negligible. Similarly, the polyclonal plots sustained high clonal diversity with no prevalence of a single genotype. The growth characteristics of the five quantitatively investigated genotypes significantly differed from each other (α = 0.05): dry biomass per stem 5–18 g, panicles per m2 20–60, average stem diameter 3.5–6 mm, height 170–250 cm. Similarly, the persistence of genotypes at the planted plots and their invasiveness (ability to invade neighboured plots) varied. These results show that common reed stands are extremely persistent even if established with genotypes that are likely not to be locally adapted. Their genetic structure remained stable for at least 24 years regardless of the planting density (1, 4, and 10 plants per m2). Our results indicate that farmers may be able to maintain favourable genotypes for many years, thus the selection and breeding of common reed as a versatile crop for rewetted peatlands is a promising objective for paludiculture research.
Purpose
Patient-reported outcome (PRO) measures are increasingly important in evaluating medical care. The increased integration of technology within the healthcare systems allows for collection of PROs electronically. The objectives of this study were to Ashley et al. J Med Internet Res (2013) implement an electronic assessment of PROs in inpatient cancer care and test its feasibility for patients and Dawson et al. BMJ (2010) determine the equivalence of the paper and electronic assessment.
Methods
We analyzed two arms from a study that was originally designed to be an interventional, three-arm, and multicenter inpatient trial. A self-administered questionnaire based on validated PRO-measures was applied and completed at admission, 1 week after, and at discharge. For this analysis — focusing on feasibility of the electronic assessment — the following groups will be considered: Group A (intervention arm) received a tablet version, while group B (control arm) completed the questionnaire on paper. A feasibility questionnaire, that was adapted from Ashley et al. J Med Internet Res (2013), was administered to group A.
Results
We analyzed 103 patients that were recruited in oncology wards. ePRO was feasible to most patients, with 84% preferring the electronic over paper-based assessment. The feasibility questionnaire contained questions that were answered on a scale ranging from “1” (illustrating non achievement) to “5” (illustrating achieving goal). The majority (mean 4.24, SD .99) reported no difficulties handling the electronic tool and found it relatively easy finding time for filling out the questionnaire (mean 4.15, SD 1.05). There were no significant differences between the paper and the electronic assessment regarding the PROs.
Conclusion
Results indicate that electronic PRO assessment in inpatient cancer care is feasible.
Objective
Maternal pre-pregnancy underweight, overweight and obesity might increase the risk for worse short- and long-term outcome in the offspring. There is a need for further study into the relationship between maternal pre-pregnancy body mass index (BMI) and the combined outcome of physical development, state of health and social behavior in children. Question: Is maternal pre-pregnancy BMI associated with the child outcome in terms of physical development, state of health and social behavior (school and leisure time behavior) at the age of 9 to 15 years?
Methods
In the population-based birth cohort study Survey of Neonates in Pomerania (SNIP) children at the age 9–15 years and their families were re-examined by questionnaire-based follow-up. 5725 mother–child pairs were invited to SNiP-follow-up. This analysis is based on the recall fraction of 24.1% (n = 1379). Based on the maternal pre-pregnancy BMI (ppBMI), 4 groups were formed: underweight (ppBMI < 19 kg/m2, n = 117), normal weight (ppBMI 19–24.99 kg/m2, n = 913, reference), overweight (ppBMI 25–30 kg). /m2, n = 237) and obesity (ppBMI > 30 kg/m2, n = 109).
Results
In the multiple regression model, the BMI-z-score for children of mothers in the underweight group was −0.50 lower, and 0.50/1.07 higher in the overweight/obese group (p < 0.001) compared to reference at median age of 12 years. No differences were found in children of underweight mothers with regard to social behavior (interaction with friends and family), school and sports performance (coded from “very good” to “poor”), other leisure activities (watching television, using mobile phones, gaming), and health (occurrence of illnesses) compared to children of normal weight mothers. In contrast, maternal pre-pregnancy overweight and obesity were associated with lower school and sports performance, and higher screen time (smart phone, gaming, television) compared to children of normal weight mothers.
Conclusion
Maternal pre-pregnancy overweight and obesity but not underweight was negatively associated with school performance and leisure time behavior in the offspring at 9–15 years of age.
Deteriorations in slow wave sleep (SWS) have been linked to brain aging and Alzheimer’s disease (AD), possibly due to its key role in clearance of amyloid-beta and tau (Aß/tau), two pathogenic hallmarks of AD. Spermidine administration has been shown to improve sleep quality in animal models. So far, the association between spermidine levels in humans and parameters of SWS physiology are unknown but may be valuable for therapeutic strategies. Data from 216 participants (age range 50–81 years) of the population-based Study of Health in Pomerania TREND were included in our analysis. We investigated associations between spermidine plasma levels, key parameters of sleep macroarchitecture and microarchitecture that were previously associated with AD pathology, and brain health measured via a marker of structural brain atrophy (AD score). Higher spermidine levels were significantly associated with lower coupling between slow oscillations and spindle activity. No association was evident for SWS, slow oscillatory, and spindle activity throughout non-rapid eye movement sleep. Furthermore, elevated spermidine blood levels were significantly associated with a higher AD score, while sleep markers revealed no association with AD score. The association between higher spermidine levels and brain health was not mediated by coupling between slow oscillations and spindle activity. We report that higher spermidine blood levels are associated not only with deteriorated brain health but also with less advantageous markers of sleep quality in older adults. Future studies need to evaluate whether sleep, spermidine, and Aß/tau deposition are interrelated and whether sleep may play a mediating role.
This study primarily aims to determine the frequency of life-threatening conditions among pediatric patients served by the DRF, a German helicopter emergency service (HEMS) provider. It also seeks to explore the necessity of invasive procedures in this population, discussing the implications for HEMS crew training and service configuration based on current literature. We analyzed the mission registry from 31 DRF helicopter bases in Germany, focusing on 7954 children aged 10 or younger over a 5-year period (2014–2018). Out of 7954 identified children (6.2% of all primary missions), 2081 (26.2%) had critical conditions. Endotracheal intubation was needed in 6.5% of cases, while alternative airway management methods were rare (n = 14). Half of the children required intravenous access, and 3.6% needed intraosseous access. Thoracostomy thoracentesis and sonography were only performed in isolated cases.
Conclusions: Critically ill or injured children are infrequent in German HEMS operations. Our findings suggest that the likelihood of HEMS teams encountering such cases is remarkably low. Besides endotracheal intubation, life-saving invasive procedures are seldom necessary. Consequently, we conclude that on-the-job training and mission experience alone are insufficient for acquiring and maintaining the competencies needed to care for critically ill or injured children.
Background and objectives
Various cross-sectional studies have observed an association between high circulating concentrations of the adipokine chemerin and an unfavorable metabolic profile. However, the prognostic value of chemerin for the risk of associated diseases and mortality was examined only in a few studies mostly using small and highly selected patient populations. We aimed to analyze the association between plasma chemerin concentrations and all-cause as well as cause-specific mortality in the general population.
Study design and methods
From the Study of Health in Pomerania (SHIP), participants of two independent cohorts (SHIP-START-1 [n = 3037], SHIP-TREND-0 [n = 4193]) were followed up for 15 and 9 years (median), respectively. The association between plasma chemerin and all-cause mortality was analyzed using multivariable Cox proportional hazard regression models. Additionally, cause-specific hazards for cardiovascular disease (CVD) and cancer mortality were modeled considering competing events.
Results
A total number of 507 and 208 deaths occurred during follow-up in SHIP-START-1 and SHIP-TREND-0, respectively. Multivariable regression analyses revealed a significant association between high plasma chemerin concentrations and greater overall mortality that was independent of major confounders. Each 30 ng/mL increase in chemerin was associated with a 17% higher risk of all-cause mortality (95%-confidence interval: 1.10–1.26). Cause-specific analyses further showed that the chemerin concentration was significantly associated with cancer mortality but not with CVD mortality.
Conclusion
The present study detected a positive association between plasma chemerin concentrations and all-cause mortality in a large population-based study sample. Cause-specific analyses have shown that chemerin is likely to play a decisive role in cancer-related deaths. However, a direct association with cardiovascular mortality could not be established.
In general, concepts such as chemical equilibria and classical analytical chemistry, as well as instrumental methods such as potentiometry and flow injection analysis (FIA), are taught separately in the curricula of chemistry-related degree programs. However, FIA provides an opportunity to connect all of these important topics. This article shows how simple experiments can be used to link the fundamentals of FIA and potentiometry to the fundamentals of chemical equilibria and teach them in a sustainable way. The experiments were designed for undergraduate environmental science students with basic knowledge of chemical equilibria and classical analytical chemistry and minimal knowledge of electrochemistry. However, they can also be integrated into various courses on instrumental analysis in chemistry-related degree programs.
Background
One of the main treatment goals in cochlear implant (CI) patients is to improve speech perception. One of the target parameters is speech intelligibility in quiet. However, treatment results show a high variability, which has not been sufficiently explained so far. The aim of this noninterventional retrospective study was to elucidate this variability using a selected population of patients in whom etiology was not expected to have a negative impact on postoperative speech intelligibility.
Materials and methods
Audiometric findings of the CI follow-up of 28 adult patients after 6 months of CI experience were evaluated. These were related to the preoperative audiometric examination and evaluated with respect to a recently published predictive model for the postoperative monosyllabic score.
Results
Inclusion of postoperative categorical loudness scaling and hearing loss for Freiburg numbers in the model explained 55% of the variability in fitting outcomes with respect to monosyllabic word recognition.
Conclusion
The results of this study suggest that much of the cause of variability in fitting outcomes can be captured by systematic postoperative audiometric checks. Immediate conclusions for CI system fitting adjustments may be drawn from these results. However, the extent to which these are accepted by individual patients and thus lead to an improvement in outcome must be subject of further studies, preferably prospective.
Scribble complex proteins can influence cell fate decisions and self-renewal capacity of hematopoietic cells. While specific cellular functions of Scribble complex members are conserved in mammalian hematopoiesis, they appear to be highly context dependent. Using CRISPR/Cas9-based genetic screening, we have identified Scribble complex-related liabilities in AML including LLGL1. Despite its reported suppressive function in HSC self-renewal, inactivation of LLGL1 in AML confirms its relevant role for proliferative capacity and development of AML. Its function was conserved in human and murine models of AML and across various genetic backgrounds. Inactivation of LLGL1 results in loss of stemness-associated gene-expression including HoxA-genes and induces a GMP-like phenotype in the leukemia stem cell compartment. Re-expression of HoxA9 facilitates functional and phenotypic rescue. Collectively, these data establish LLGL1 as a specific dependency and putative target in AML and emphasizes its cell-type specific functions.
The classical Buscher rules d escribe T-duality for metrics and B-fields in a topologically trivial setting. On the other hand, topological T-duality addresses aspects of non-trivial topology while neglecting metrics and B-fields. In this article, we develop a new unifying framework for both aspects.
The German Centre for Cardiovascular Research (DZHK) is one of the German Centres for Health Research and aims to conduct early and guideline-relevant studies to develop new therapies and diagnostics that impact the lives of people with cardiovascular disease. Therefore, DZHK members designed a collaboratively organised and integrated research platform connecting all sites and partners. The overarching objectives of the research platform are the standardisation of prospective data and biological sample collections among all studies and the development of a sustainable centrally standardised storage in compliance with general legal regulations and the FAIR principles. The main elements of the DZHK infrastructure are web-based and central units for data management, LIMS, IDMS, and transfer office, embedded in a framework consisting of the DZHK Use and Access Policy, and the Ethics and Data Protection Concept. This framework is characterised by a modular design allowing a high standardisation across all studies. For studies that require even tighter criteria additional quality levels are defined. In addition, the Public Open Data strategy is an important focus of DZHK. The DZHK operates as one legal entity holding all rights of data and biological sample usage, according to the DZHK Use and Access Policy. All DZHK studies collect a basic set of data and biosamples, accompanied by specific clinical and imaging data and biobanking. The DZHK infrastructure was constructed by scientists with the focus on the needs of scientists conducting clinical studies. Through this, the DZHK enables the interdisciplinary and multiple use of data and biological samples by scientists inside and outside the DZHK. So far, 27 DZHK studies recruited well over 11,200 participants suffering from major cardiovascular disorders such as myocardial infarction or heart failure. Currently, data and samples of five DZHK studies of the DZHK Heart Bank can be applied for.